Mechanisms of Lymphocyte Activation and Immune Regulation VIII: Autoimmunity 2000 and Beyond

Mechanisms of Lymphocyte Activation and Immune Regulation VIII: Autoimmunity 2000 and Beyond

by Sudhir Gupta
     
 

Advances in biochemistry, cell biology, genome-wide mutagenesis - coupled with molecular technology, including gene microarray and transgenic and knock-out animals - have been instrumental in understanding the cellular processes and molecular pathways of self-tolerance and autoimmune diseases. The molecular definition of these pathways and processes has led to

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Overview

Advances in biochemistry, cell biology, genome-wide mutagenesis - coupled with molecular technology, including gene microarray and transgenic and knock-out animals - have been instrumental in understanding the cellular processes and molecular pathways of self-tolerance and autoimmune diseases. The molecular definition of these pathways and processes has led to novel treatments for certain auto-immune diseases that are based on the pathogenesis of diseases rather than on broad-spectrum immunosuppression. This book reviews many of these current developments and proposes future novel approaches for understanding the pathogenesis of auto-immune diseases and designing novel therapy. This book covers three major areas of auto-immunity: the basic mechanisms of immunological tolerance, pathogenesis of auto-immune diseases, and some novel therapies.
This book should be useful for immunologists, molecular biologists, rheumatologists, and clinical scientists.

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Editorial Reviews

Reviews current developments in understanding the cellular processes and molecular pathways of self-tolerance and autoimmune diseases, and proposes new approaches to investigating the pathogenesis of autoimmune diseases and designing novel therapy. The 13 papers characterize mouse models that spontaneously develop systemic lupus erythematosus, identify the role of MHC class II molecules in the prevention of type I diabetes, and assess the pros and cons of using EAE as a predictor of success for new drugs in multiple sclerosis. Other topics include the control of autoimmunity by regulatory T cells, the genetic basis of autoimmune lymphoproliferative syndrome (ALPS), and cytokine blockage in rheumatoid arthritis. Annotation c. Book News, Inc., Portland, OR

Product Details

ISBN-13:
9781461354581
Publisher:
Springer US
Publication date:
12/31/2012
Series:
Advances in Experimental Medicine and Biology Series, #490
Edition description:
Softcover reprint of the original 1st ed. 2001
Pages:
136
Product dimensions:
6.14(w) x 9.21(h) x 0.32(d)

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