Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery / Edition 1

Paperback (Print)
Used and New from Other Sellers
Used and New from Other Sellers
from $61.00
Usually ships in 1-2 business days
(Save 48%)
Other sellers (Paperback)
  • All (8) from $61.00   
  • New (5) from $61.00   
  • Used (3) from $149.90   

Overview

There have been tremendous advances in understanding the cellular mechanisms involved in sepsis and contributing to the development of multiple organ dysfunction and mortality in this setting. The chapters in this book provide up-to-date insights into important pathways that are initiated by sepsis.

Read More Show Less

Editorial Reviews

Doody's Review Service
Reviewer: David J. Dries, MD (University of Minnesota Medical School)
Description: This collection of essays, volume 44 in the Update in Intensive Care and Emergency Medicine series, describes specific patterns and mediators of organ failure in the setting of infection.
Purpose: Global mediators, cellular and tissue-specific changes in the setting of infection are collected from reports of the laboratories doing this work.
Audience: Senior trainees and practitioners in multidisciplinary critical care medicine are an appropriate audience for this book edited and written by an international group of critical care and sepsis leaders.
Features: After introductory comments that provide a unifying force for the presentations, mediators of inflammation are discussed followed by components of the pattern of cellular injury seen in sepsis. Later chapters include metabolic changes and a concluding group of essays focus on organ specific dysfunction. Chapters are well written and include line drawings and tables to summarize data. An ample reference list follows each presentation with references dating to within two years of publication, which represent original work.
Assessment: This is a good compilation of recent work done at the level of cytokines, cells, and tissues to help understand and treat this important problem. Consistent with clinical practice, cellular and organ dysfunction are emphasized while we still know relatively little about the tipping point between cell and tissue death and recovery. This is a worthy overview for the academic clinician facing sepsis at the bedside.
Read More Show Less

Product Details

  • ISBN-13: 9783540301585
  • Publisher: Springer Berlin Heidelberg
  • Publication date: 8/28/2007
  • Series: Update in Intensive Care Medicine Series
  • Edition description: 2007
  • Edition number: 1
  • Pages: 453
  • Product dimensions: 6.10 (w) x 9.20 (h) x 0.70 (d)

Table of Contents

Setting the Scene.- Setting the Scene.- The Inflammatory Response.- Genetics and Severe Sepsis.- Cell Signaling Pathways of the Innate Immune System During Acute Inflammation.- Early-Onset Pro-inflammatory Cytokines.- The Significance of HMGB1, a Late-Acting Pro-inflammatory Cytokine.- Nitric Oxide.- Involvement of Reactive Oxygen and Nitrogen Species in the Pathogenesis of Acute Lung Injury.- Heat Shock Proteins in Inflammation.- Fibrosis in the Acute Respiratory Distress Syndrome.- Resolution of Inflammation.- The Cellular Immune Respone.- Compartmentalized Activation of Immune Cells During Sepsis and Organ Dysfunction.- The Neutrophil in the Pathogenesis of Multiple Organ Dysfunction Syndrome.- The Role of the Macrophage.- The Role of the Endothelium.- Differential Effects of Pro-Inflammatory Mediators on Alveolar Epithelial Barrier Function.- Mechanisms and Pathways of Dysfunction.- Macrocirculatory Disturbances.- The Microcirculation Is a Vulnerable Organ in Sepsis.- The Cholinergic Anti-inflammatory Pathway: Connecting the Mind and Body.- Coagulation in Sepsis.- The Role of Insulin and Blood Glucose Control.- Dysfunction of the Bioenergetic Pathway.- Metabolic Pathways.- Cell Death and Acute Lung Injury.- Mechanisms of Immunodepression after Central Nervous System Injury.- Organ-specific Mechanisms of Dysfunction.- Pulmonary Dysfunction.- The Gut.- Endogenous Danger Signals in Liver Injury: Role of High Mobility Group Box Protein-1.- Sepsis-induced Acute Renal Failure and Recovery.- Sepsis-Induced Brain Dysfunction.- Myocardial Depression in Sepsis and Septic Shock.- Skeletal Muscle.

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)