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Mechanisms of Stimulus-Response Coupling in Platelets

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Product Details

  • ISBN-13: 9781461594444
  • Publisher: Springer US
  • Publication date: 4/30/2013
  • Series: Advances in Experimental Medicine and Biology Series , #192
  • Edition description: Softcover reprint of the original 1st ed. 1985
  • Edition number: 1
  • Pages: 444
  • Product dimensions: 6.69 (w) x 9.61 (h) x 0.93 (d)

Table of Contents

Platelet Receptors.- Structure and Organisation of Platelet Membranes.- Platlet Receptors for Thrombin.- Characterisation of ADP Receptors.- Fibrinogen and Platelet Function.- Characterisation of Factor VIII Receptors.- Characterization of Thromboxane Receptors in Human Platelets.- Specific Binding of [3H]-1-O-Octadecyl PAF-Acether to Washed Human Platelets.- Characterisation of Human Platelet Adrenoceptors.- Specificity Between the Anti-Aggregatory Actions of Prostacyclin, Prostaglandin E1 and D2 on Platelets.- Control of Calcium Mobilization.- Agonist-Induced Inositol Phospholipid Metabolism and Ca++ Flux in Human Platelet Activation.- Control and Interrelation of Aggregation and Secretion; The Roles of Ca2+, Diacylglycerol and Thromboxane with Particular Reference to ADP Stimulation.- Measurement of Intracellular Platelet Calcium with Aequorin and Quin 2.- Permeabilised Platelets and Exocytosis.- Platelet Membranes, Eicosanoid Biosynthesis and Putative Endogenous Calcium Ionophores.- Hydrolysis of Cytoskeletal Proteins by The Ca2+-Dependent Protease During Platelet Activation.- Phosphorylation of Platelet Proteins and Nucleotide Metabolism.- Energy Requirements of Stimulus-Response Coupling.- Platelet Protein Phosphorylation.- Protein Kinase C and Granule Release in Human Platelets.- Receptor-Effector Coupling in Platelets: Roles of Guanine Nucleotides.- Products of Phospholipid Metabolism.- Regulation of Platelet Phospholipid Metabolism.- Role of Thromboxane A2.- Role of PAF-Acether and Related Ether-Lipid Metabolism in Platelets.- Role of Lipoxygenase Products in Platelet Function: Relation to Fatty Acid Modified Phospholipids.- Biological Actions of Prostacyclin and Its Pharmacological use in Platelet Studies.- Functional Platelet Responses.- Development of Procoagulant Binding Sites on the Platelet Surface.- Mechanism of Inhibition of Platelet Coagulant Activity.- Platelet Interaction with the Contact System of Coagulation.- Adenosine Diphosphate as a Mediator of Platelet Aggregation in vivo.- Molecular Mechanism of Platelet Adhesion.- Endothelium as a Modulator of Platelet Reactivity.- Platelet-Derived Heparin Neutralizing Proteins.

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