Mechanosensitive Ion Channels / Edition 1

by I. Lozinsky, Andre Kamkin, M.J. Lab, Irina Kiseleva, J. Hescheler

Overview

This book is devoted to discussing the latest data dealing with mechanosensitive channels research results. It was compiled by a group of internationally recognized scientists leading in the field of mechanosensitive ion channels or mechanically gated channels and mechanosensitive signaling cascades research. Key problems of cell mechanobiology are also discussed. The reviews included here deal with experimental methods of studying mechanosensitive channels, role of lipid bilayer mechanics in mechanosensation, molecular organization, physiology and pharmacology of various channels reacting to membrane tension as a stimulus. The book also examines mechanotransduction, which the authors define as the biochemical response of cells to mechanical stimulation. As a whole, the volume dwells on the major issues of mechanical stress influencing the ion channels and intracellular signaling pathways. The book presents not only the latest achievements in the field but also brings the understanding of the problem closer to the experts in related medical and biological sciences as well as practicing doctors.

Product Details

ISBN-13:	9781402064258
Publisher:	Springer Netherlands
Publication date:	12/04/2007
Series:	Mechanosensitivity in Cells and Tissues , #1
Edition description:	2008
Pages:	382
Product dimensions:	6.10(w) x 9.25(h) x 0.03(d)

Table of Contents

Mechanosensitive Channels.- Experimental Methods of Studying Mechanosensitive Channels and Possible Errors in Data Interpretation.- Role of Lipid Bilayer Mechanics in Mechanosensation.- Mechanosensitive Channels Gated by Membrane Tension.- Computational Studies of the Bacterial Mechanosensitive Channels.- Mechanosensory Transduction in the Nematode Caenorhabditis elegans.- Mechanosensitive Ion Channels in Odontoblasts.- Potassium Ion Channels in Articular Chondrocytes.- Osmotransduction Through Volume-Sensitive Cl- Channels.- Mechanosensitive Channel TRPV4.- Mechanosensitive Signalling Cascades.- Mechanosensitive Purinergic Calcium Signalling in Articular Chondrocytes.- Signal Transduction Pathways Involved in Mechanotransduction in Osteoblastic and Mesenchymal Stem Cells.- Caveolae.- Multimodal Activation and Regulation of Neuronal Mechanosensitive Cation Channels.- Regulation of Intracellular Signal Transduction Pathways by Mechanosensitive Ion Channels.- Cell Mechanobiology.- The Effects of Mechanical Stimulation on Vertebrate Hearts.- Mechanobiology of Fibroblasts.