Medical Implications of Biofilms

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Overview

Interest in biofilms has increased dramatically in recent years. New microscopic and molecular techniques have revolutionized our understanding of biofilm structure, composition, organization, and activities. This book brings advances in the prevention and treatment of biofilm-related diseases to the attention of clinicians and medical researchers. Human tissues often support complex microbial communities growing as biofilms that can cause infections. As microbes in biofilms exhibit increased tolerance toward anti-microbial agents and decreased susceptibility to host defense systems, biofilm-associated diseases have become increasingly difficult to treat.

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Editorial Reviews

From the Publisher
"I found this book a real pleasure to read, as it covers many topics on medically important biofilms and advancements in the prevention and treatment of such diseases. The book would be suitable for both clinicians and medical researchers. The wide range of topics covered makes this work a perfect review for those interested in medically related biofilms." ASM News
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Product Details

  • ISBN-13: 9780521812405
  • Publisher: Cambridge University Press
  • Publication date: 9/28/2003
  • Pages: 328
  • Product dimensions: 5.98 (w) x 8.98 (h) x 0.94 (d)

Table of Contents

Preface
List of Contributors
1 Biofilm-Dependent Regulation of Gene Expression 3
2 Quorum Sensing and Microbial Biofilms 18
3 Antimicrobial Agents and Biofilms 36
4 Animal Models of Orthopaedic Implant Infection 59
5 Intravascular-Catheter-Related Infections 86
6 Molecular Basis of Biofilm Formation by Staphylococcus epidermidis 110
7 Biofilm Complications of Urinary Tract Devices 136
8 Novel Microscopic Methods to Study the Structure and Metabolism of Oral Biofilms 173
9 Oral Streptococcal Genes That Encode Biofilm Formation 189
10 Gene Expression in Oral Biofilms 212
11 Dissection of the Genetic Pathway Leading to Multicellular Behaviour in Salmonella enterica Serotype Typhimurium and Other Enterobacteriaceae 231
12 Bacterial Growth on Mucosal Surfaces and Biofilms in the Large Bowel 262
13 Pseudomonas aeruginosa Biofilms in Lung Infection 287
Index 311
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