Medical Pharmacology and Therapeutics / Edition 3

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The third edition of Medical Pharmacology and Therapeutics provides a basis for learning about safe and effective prescribing of modern medicines.

It does this by including descriptions of the pathogenic mechanisms of the disease or condition, where and how drugs have their actions and unwanted effects, and the therapeutic principles of drug use.

Medical Pharmacology and Therapeutics is ideal reading for medical students and all health professionals from the start of their course until after they have qualified.

Key features of the new edition include:

Fully revised text that links current knowledge of disease pathophysiology with mechanisms of drug action and therapeutic principles

Important drug examples in the text to illustrate each drug class, with a redesigned, comprehensive drug compendium at the end of each chapter

Updated self assessment and clinical case studies

New sections on pulmonary hypertension, attention deficit hyperactivity disorder and narcolepsy

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Editorial Reviews

From the Publisher
"First of all it is British and so ideal for those of us in the UK...It is also bang up to date..It's laid out in typical textbook style and is organised into general principles and body systems... The text is broken up into digestible chunks and good use is made of colour whilst there is plenty of self assessment to pit your wit against. It is a great book, ideal for undergraduates, but it is also a super reference source for clinicans wanting to brush up their knowledge. It is an ideal adjunct to the BNF."

Glycosmedia, March 2014

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Product Details

  • ISBN-13: 9780702029912
  • Publisher: Elsevier Health Sciences
  • Publication date: 2/10/2010
  • Edition number: 3
  • Pages: 744
  • Product dimensions: 7.60 (w) x 10.40 (h) x 1.20 (d)

Table of Contents

Preface vii

Drug dosage and nomenclature ix

Section 1 General principles

1 Principles of pharmacology and mechanisms of drug action 3

2 Pharmacokinetics 31

3 Drug discovery, safety and efficacy 63

4 The nervous system, neurotransmission and the peripheral autonomic nervous system 71

Section 2 The cardiovascular system

5 Ischaemic heart disease 91

6 Systemic and pulmonary hypertension 111

7 Heart failure 133

8 Cardiac arrhythmias 145

9 Cerebrovascular disease and dementia 163

10 Peripheral vascular disease 171

11 Haemostasis 177

Section 3 The respiratory system

12 Asthma and chronic obstructive pulmonary disease 195

13 Respiratory disorders: cough, respiratory stimulants, cystic fibrosis and neonatal respiratory distress syndrome 211

Section 4 The renal system

14 Diuretics 219

15 Disorders of micturition 231

16 Erectile dysfunction 239

Section 5 The nervous system

17 General anaesthetics 247

18 Local anaesthetics 257

19 Opioid analgesics and the management of pain 263

20 Anxiolytics, sedatives and hypnotics 277

21 The major psychotic disorders: schizophrenia and mania 287

22 Depression, attention deficit hyperactivity disorder and narcolepsy 299

23 Epilepsy 315

24 Extrapyramidal movement disorders and spasticity 327

25 Other neurological disorders: multiple sclerosis, motor neuron disease and Guillain-Barré syndrome 341

26 Migraine 345

Section 6 The musculoskeletal system

27 The neuromuscular junction and neuromuscular blockade 355

28 Myasthenia gravis 361

29 Non-steroidal anti-inflammatory drugs 365

30 Rheumatoid arthritis, other inflammatory arthritides and osteoarthritis 377

31 Hyperuricaemia and gout 387

Section 7 The gastrointestinal system

32 Nausea and vomiting 395

33 Dyspepsia and peptic ulcer disease 403

34 Inflammatory bowel disease 415

35 Constipation, diarrhoea and irritable bowel syndrome 421

36 Liver disease 429

37 Obesity 437

Section 8 The immune system

38 The immune response and immunosuppressant drugs 445

39 Antihistamines and allergic disease 455

Section 9 The endocrine system and metabolism

40 Diabetes mellitus 463

41 The thyroid and control of metabolic rate 477

42 Calcium metabolism and metabolic bone disease 483

43 Pituitary and hypothalamic hormones 493

44 Corticosteroids (glucocorticoids and mineralocorticoids) 505

45 Female reproduction 515

46 Androgens and anabolic steroids 535

47 Anaemia and haematopoietic colony-stimulating factors 541

48 Lipid disorders 551

Section 10 The skin and eyes

49 Skin disorders 565

50 The eye 575

Section 11 Chemotherapy

51 Chemotherapy of infections 587

52 Chemotherapy of malignancy 641

Section 12 General features: toxicity and prescribing

53 Drug toxicity and overdose 671

54 Substance abuse and dependence 687

55 Prescribing, adherence and information about medicines 699

56 Drug therapy in special situations 703

Index 715

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