Medical Physiology / Edition 9

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Overview

A comprehensive yet concise new edition geared toward medical and dental students taking physiology courses. Textbook of Medical Physiology also serves as an ideal review resource for physiology teachers. It offers specific discussions of pathophysiology in most clinical areas of medicine.

The book contains predominantly two-color illustrations, with some black-and-white illustrations.

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Editorial Reviews

Robert W. Teel
This is the tenth revision of a comprehensive and thorough coverage of human physiology. The current edition has evolved over 50 years with only minor refinements appearing in the latest revision. The same number of units and chapters appear in this newest edition as in the previous one, and there are about 80 fewer pages, updated from 1996. This useful format provides an in-depth textbook in medical physiology for students. It can also serve as a useful reference source for teachers and practicing healthcare professionals. The text is appropriate for upper division majors in physiology but is of particular value to medical students and graduate students in physiology. Physiology of the major systems of the human body are covered, with a special emphasis on homeostasis and interaction of systems. Readability continues to be a strength. The index is thorough and very useful. The cardiovascular and renal sections are particularly well done. The section on aviation, space, and deep-sea physiology is a plus. This latest edition is not much different than the previous one. Print may be easier to read and red boxes around figure numbers focuses attention. I had difficulty noting any significant difference in material content; the differences seem mostly cosmetic. I actually prefer the format of the ninth edition. This text still lacks the strength of some other texts where more specialists have authored chapters specific to their areas of expertise. Figures lack the flair of other texts, but understand that this minimizes publication costs.
John G. Wood
This is the ninth edition of a highly successful textbook of medical physiology, in which physiological concepts are described in a comprehensive, organized manner from the cellular level to integrated systems. . According to the authors, the goals are to emphasize integrated physiology and homeostatic mechanisms and be as accurate as possible. These are clearly worthy objectives, and I believe this is a valuable resource for teaching medical physiology. In general, the book adequately fulfills the authors' objectives. The authors indicate that it is written primarily for medical students, and I agree. They are highly respected physiologists who have made many significant contributions to this field. I found very few (if any) new figures in the chapters on the gastrointestinal system, compared with the previous edition. The references have been updated in the gastrointestinal sections, but I found few changes in the text of this revision. Based upon close reading of the chapters of the gastrointestinal system, there appears to have been little revision of the text in this version. Recent references have been added to the chapters, yet I did not find this material to have been incorporated into the text. Although the book is overall of high quality, I did not see sufficient changes to justify the purchase of this revision.
Doody's Review Service
Reviewer: Robert W. Teel, PhD (Loma Linda University)
Description: This is the tenth revision of a comprehensive and thorough coverage of human physiology. The current edition has evolved over 50 years with only minor refinements appearing in the latest revision. The same number of units and chapters appear in this newest edition as in the previous one, and there are about 80 fewer pages, updated from 1996.
Purpose: This useful format provides an in-depth textbook in medical physiology for students. It can also serve as a useful reference source for teachers and practicing healthcare professionals.
Audience: The text is appropriate for upper division majors in physiology but is of particular value to medical students and graduate students in physiology.
Features: Physiology of the major systems of the human body are covered, with a special emphasis on homeostasis and interaction of systems. Readability continues to be a strength. The index is thorough and very useful. The cardiovascular and renal sections are particularly well done. The section on aviation, space, and deep-sea physiology is a plus.
Assessment: This latest edition is not much different than the previous one. Print may be easier to read and red boxes around figure numbers focuses attention. I had difficulty noting any significant difference in material content; the differences seem mostly cosmetic. I actually prefer the format of the ninth edition. This text still lacks the strength of some other texts where more specialists have authored chapters specific to their areas of expertise. Figures lack the flair of other texts, but understand that this minimizes publication costs.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780721659442
  • Publisher: Elsevier Health Sciences
  • Publication date: 8/1/1995
  • Edition description: Older Edition
  • Edition number: 9
  • Pages: 1148
  • Product dimensions: 8.86 (w) x 11.34 (h) x 1.71 (d)

Meet the Author

Arthur C. Guyton, MD, Professor Emeritus, Department of Physiology & Biophysics, University of Mississippi Medical Center, Jackson, MS;

John E. Hall, PhD, Professor and Chairman, Department of Physiology & Biophysics, University of Mississippi Medical Center, Jackson, MS

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Table of Contents

Unit I Introduction to Physiology: The Cell and General Physiology
Ch. 1 Functional Organization of the Human Body and Control of the "Internal Environment" 2
Ch. 2 The Cell and Its Function 9
Ch. 3 Genetic Control of Protein Synthesis, Cell Function, and Cell Reproduction 24
Unit II Membrane Physiology, Nerve, and Muscle
Ch. 4 Transport of Substances Through the Cell Membrane 40
Ch. 5 Membrane Potentials and Action Potentials 52
Ch. 6 Contraction of Skeletal Muscle 67
Ch. 7 Excitation of Skeletal Muscle: A. Neuromuscular Transmission and B. Excitation-Contraction Coupling 80
Ch. 8 Contraction and Excitation of Smooth Muscle 87
Unit III The Heart
Ch. 9 Heart Muscle; The Heart as a Pump 96
Ch. 10 Rhythmical Excitation of the Heart 107
Ch. 11 The Normal Electrocardiogram 114
Ch. 12 Electrocardiographic Interpretation of Cardiac Muscle and Coronary Blood Flow Abnormalities: Vectorial Analysis 120
Ch. 13 Cardiac Arrhythmias and Their Electrocardiographic Interpretation 134
Unit IV The Circulation
Ch. 14 Overview of the Circulation; Medical Physics of Pressure, Flow, and Resistance 144
Ch. 15 Vascular Distensibility, and Functions of the Arterial and Venous Systems 152
Ch. 16 The Microcirculation and the Lymphatic System: Capillary Fluid Exchange, Interstitial Fluid, and Lymph Flow 162
Ch. 17 Local Control of Blood Flow by the Tissues; and Humoral Regulation 175
Ch. 18 Nervous Regulation of the Circulation, and Rapid Control of Arterial Pressure 184
Ch. 19 Dominant Role of the Kidney in Long-Term Regulation of Arterial Pressure and in Hypertension: The Integrated System for Pressure Control 195
Ch. 20 Cardiac Output, Venous Return, and Their Regulation 210
Ch. 21 Muscle Blood Flow and Cardiac Output During Exercise; the Coronary Circulation and Ischemic Heart Disease 223
Ch. 22 Cardiac Failure 235
Ch. 23 Heart Valves and Heart Sounds; Dynamics of Valvular and Congenital Heart Defects 245
Ch. 24 Circulatory Shock and Physiology of Its Treatment 253
Unit V The Kidneys and Body Fluids
Ch. 25 The Body Fluid Compartments: Extracellular and Intracellular Fluids; Interstitial Fluid and Edema 264
Ch. 26 Urine Formation by the Kidneys: I. Glomerular Filtration, Renal Blood Flow, and Their Control 279
Ch. 27 Urine Formation by the Kidneys: II. Tubular Processing of the Glomerular Filtrate 295
Ch. 28 Regulation of Extracellular Fluid Osmolarity and Sodium Concentration 313
Ch. 29 Integration of Renal Mechanisms for Control of Blood Volume and Extracellular Fluid Volume; and Renal Regulation of Potassium, Calcium, Phosphate, and Magnesium 329
Ch. 30 Regulation of Acid-Base Balance 346
Ch. 31 Micturition, Diuretics, and Kidney Diseases 364
Unit VI Blood Cells, Immunity, and Blood Clotting
Ch. 32 Red Blood Cells, Anemia, and Polycythemia 382
Ch. 33 Resistance of the Body to Infection: I. Leukocytes, Granulocytes, the Monocyte-Macrophage System, and Inflammation 392
Ch. 34 Resistance of the Body to Infection: II. Immunity and Allergy 402
Ch. 35 Blood Groups; Transfusion; Tissue and Organ Transplantation 413
Ch. 36 Hemostasis and Blood Coagulation 419
Unit VII Respiration
Ch. 37 Pulmonary Ventilation 432
Ch. 38 Pulmonary Circulation; Pulmonary Edema; Pleural Fluid 444
Ch. 39 Physical Principles of Gas Exchange; Diffusion of Oxygen and Carbon Dioxide Through the Respiratory Membrane 452
Ch. 40 Transport of Oxygen and Carbon Dioxide in the Blood and Body Fluids 463
Ch. 41 Regulation of Respiration 474
Ch. 42 Respiratory Insufficiency - Pathophysiology, Diagnosis, Oxygen Therapy 484
Unit VIII Aviation, Space, and Deep-Sea Diving Physiology
Ch. 43 Aviation, High-Altitude, and Space Physiology 496
Ch. 44 Physiology of Deep-Sea Diving and Other Hyperbaric Conditions 504
Unit IX The Nervous System: A. General Principles and Sensory Physiology
Ch. 45 Organization of the Nervous System; Basic Functions of Synapses and Transmitter Substances 512
Ch. 46 Sensory Receptors; Neuronal Circuits for Processing Information 528
Ch. 47 Somatic Sensations: I. General Organization; the Tactile and Position Senses 540
Ch. 48 Somatic Sensations: II. Pain, Headache, and Thermal Sensations 552
Unit X The Nervous System: B. The Special Senses
Ch. 49 The Eye: I. Optics of Vision 566
Ch. 50 The Eye: II. Receptor and Neural Function of the Retina 578
Ch. 51 The Eye: III. Central Neurophysiology of Vision 591
Ch. 52 The Sense of Hearing 602
Ch. 53 The Chemical Senses - Taste and Smell 613
Unit XI The Nervous System: C. Motor and Integrative Neurophysiology
Ch. 54 Motor Functions of the Spinal Cord; The Cord Reflexes 622
Ch. 55 Cortical and Brain Stem Control of Motor Function 634
Ch. 56 The Cerebellum, the Basal Ganglia, and Overall Motor Control 647
Ch. 57 The Cerebral Cortex; Intellectual Functions of the Brain; and Learning and Memory 663
Ch. 58 Behavioral and Motivational Mechanisms of the Brain - The Limbic System and the Hypothalamus 678
Ch. 59 States of Brain Activity - Sleep; Brain Waves; Epilepsy; Psychoses 689
Ch. 60 The Autonomic Nervous System; and the Adrenal Medulla 697
Ch. 61 Cerebral Blood Flow; the Cerebrospinal Fluid; and Brain Metabolism 709
Unit XII Gastrointestinal Physiology
Ch. 62 General Principles of Gastrointestinal Function - Motility, Nervous Control, and Blood Circulation 718
Ch. 63 Propulsion and Mixing of Food in the Alimentary Tract 728
Ch. 64 Secretory Functions of the Alimentary Tract 738
Ch. 65 Digestion and Absorption in the Gastrointestinal Tract 754
Ch. 66 Physiology of Gastrointestinal Disorders 764
Unit XIII Metabolism and Temperature Regulation
Ch. 67 Metabolism of Carbohydrates, and Formation of Adenosine Triphosphate 772
Ch. 68 Lipid Metabolism 781
Ch. 69 Protein Metabolism 791
Ch. 70 The Liver as an Organ 797
Ch. 71 Dietary Balances; Regulation of Feeding; Obesity and Starvation; Vitamins and Minerals 803
Ch. 72 Energetics and Metabolic Rate 815
Ch. 73 Body Temperature, Temperature Regulation, and Fever 822
Unit XIV Endocrinology and Reproduction
Ch. 74 Introduction to Endocrinology 836
Ch. 75 The Pituitary Hormones and Their Control by the Hypothalamus 846
Ch. 76 The Thyroid Metabolic Hormones 858
Ch. 77 The Adrenocortical Hormones 869
Ch. 78 Insulin, Glucagon, and Diabetes Mellitus 884
Ch. 79 Parathyroid Hormone, Calcitonin, Calcium and Phosphate Metabolism, Vitamin D, Bone, and Teeth 899
Ch. 80 Reproductive and Hormonal Functions of the Male (and Function of the Pineal Gland) 916
Ch. 81 Female Physiology Before Pregnancy; and the Female Hormones 929
Ch. 82 Pregnancy and Lactation 944
Ch. 83 Fetal and Neonatal Physiology 958
Unit XV Sports Physiology
Ch. 84 Sports Physiology 968
Index 979
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Preface

We come now to the tenth edition of the Textbook of Medical Physiology. Publication of this book has continued long beyond what we expected when its first edition was written almost 50 years ago. Yet, the project becomes more exciting each year, especially because our increasing knowledge of physiology unravels many new bodily mysteries.

Most important, many new techniques for learning about cellular and molecular physiology have been developed recently. Therefore, more and more can we present physiologic principles in the terminology of molecular and physical science rather than merely as a series of separate unexplained biological phenomena. This change we all welcome, but it also makes revision of almost every section of each chapter a necessity.

To help in this job of revision, Dr. John Hall joined as coauthor in preparing the ninth edition of the Textbook of Medical Physiology. In the tenth edition he has doubled the number of chapters for which he is primarily responsible.

The two of us, Drs. Guyton and Hall, have worked very closely together for more than 25 years, so it has been possible to maintain a unified organization of the text that is especially useful to students, yet at the same time keeps the book comprehensive enough that students will wish to use it in later life as a basis for professional careers. As can be expected, Dr. Hall has brought many new insights and new bodies of knowledge that have helped immensely in achieving these goals.

The beauty of studying human physiology is that it integrates the individual functions of all the body's different organs and cells into a functional whole, the human body. Indeed, life relies uponthis total function, not on function of individual body parts in isolation from the others.

This brings us to another subject: How are the separate organs and systems controlled so that no one overfunctions while others fail to do their share? Fortunately, our bodies are endowed with a vast network of feedback controls that achieve the necessary balances without which we would not be able to live. Physiologists call this high level of internal bodily control homeostasis. In disease states, functional balances are often seriously disturbed-that is, homeostasis becomes very poor. And, when even a single disturbance reaches a limit, the whole body can no longer live. Therefore, one of the principal goals of any medical physiology text is to emphasize the effectiveness and beauty of the body's homeostasis mechanisms as well as to present their abnormal function in disease.

Another goal of this text is to be as accurate as possible. Suggestions and critiques from many physiologists, students, and clinicians throughout the world have been sought and then used for checking factual accuracy as well as balance in the text. Even so, because of the likelihood of error in sorting through thousands of bits of information, we wish to issue still a further invitation-in fact, much more than merely an invitation, actually a request-to all readers to send along notations of error or inaccuracy. Indeed, physiologists perhaps as much as any other scholars understand how important feedback is to proper function of the human body; so, too, is feedback important for progressive development of a textbook of physiology. To those many persons who have already helped, we send our sincerest thanks.

A word of explanation is needed about two features of the text-first, the references, and second, the two print sizes. The sources referenced have been chosen primarily for their presentation of physiologic principles and for the quality of their own references. Use of these, as well as cross-references from them, can give the student almost complete coverage of the entire field of physiology.

The print is set in two sizes. The material in small print is of several different kinds: first, anatomical, chemical, and other information that is needed for immediate discussion but that most students will learn in more detail in other courses; second, physiologic information of special importance to certain fields of clinical medicine; and, third, information that will be of value to those students who may wish to study particular physiologic mechanisms more deeply.

In contrast, the material in large print constitutes the fundamental physiologic information that students will require in virtually all their medical activities and studies.

Again, we wish to express our deepest appreciation to many other persons who have helped in preparing this book. We are particularly grateful to Ivadelle Osberg Heidke, Gwendolyn Harris, and Gerry McAlpin for their excellent secretarial services; to Tomika Mita, Michael Schenk, Angela Gardner, and Myriam Kirkman for their superb work and helpfulness with the illustrations; and to the staff of W.B. Saunders Company for continued editorial and production excellence.

Arthus C. Guyton

John E. Hall

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