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Medicinal Chemistry: Principles and Practice

Overview

This book covers the key topics for drug discovery from the perspective of the practising industrial scientist and manager. Presenting all aspects of the subject from initial lead through to final development, this new edition builds on the highly successful foundations laid by the first edition by introducing new topics such as combinatorial chemistry, genomics and chemoinformatics, alongside revised and updated original chapters. Introducing the cross-disciplinary topics needed, Medicinal Chemistry: Principles ...

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Overview

This book covers the key topics for drug discovery from the perspective of the practising industrial scientist and manager. Presenting all aspects of the subject from initial lead through to final development, this new edition builds on the highly successful foundations laid by the first edition by introducing new topics such as combinatorial chemistry, genomics and chemoinformatics, alongside revised and updated original chapters. Introducing the cross-disciplinary topics needed, Medicinal Chemistry: Principles and Practice 2nd Edition embraces descriptions of targets, biology, metabolism and pharmacokinetics, genetics, patents and development chemistry. New case histories, strategy and tactics for drug discovery are also introduced. With many chapters written by practitioners from within the pharmaceutical industry, it is an invaluable introduction to medicinal chemistry for new graduates and PhDs. It will also serve to update more experienced scientists on the newer technologies in the field.

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Editorial Reviews

From the Publisher
An essential text.....presentation is clear and the text written in an understandable, readable style.
Booknews
Essentially a collation of the lectures presented at the 7th Royal Society of Chemistry Medicinal Chemistry School, held at the U. of Kent, Canterbury, in June-July 1993, this volume introduces the principles and practices of modern medicinal chemistry and covers all aspects of drug discovery from the initial lead compound into potential drug, and provides recent case histories as examples of successes Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9780854046317
  • Publisher: Royal Society of Chemistry, The
  • Publication date: 9/28/2002
  • Edition description: Second Edition
  • Edition number: 2
  • Pages: 472
  • Sales rank: 948,216
  • Product dimensions: 6.14 (w) x 9.21 (h) x 0.96 (d)

Table of Contents

Drug-Receptor Interactions; An Introduction to Ion Channels; Intracellular Targets; Enzyme Inhibitors; Biological Evaluation of Novel Compounds; Pharmacokinetics; Drug Metabolism; Toxicology in the Drug Discovery Process; Chemical Development; Physicochemical Properties; Quantitative Structure-Activity Relationships; Computational Chemistry and Target Structure; Patent Medicine; An Introduction to Molecular Biology; Strategy and Tactics in Drug Discovery; Combinatorial Chemistry: Tools for the Medicinal Chemist; The Identification of Selective 5-HT2C Receptor Antagonists: A New Approach to the Treatment of Depression and Anxiety; The Identification of the HIV Protease Inhibitor Saquinavir; Discovery of Vioxx (Rofecoxib); NK1 Receptor Antagonists; Appendices; Subject Index.

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