Medicinal Chemistry: A Molecular and Biochemical Approach / Edition 3

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Fully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and biochemical principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design, will find this book an invaluable resource.

Starting with an overview of basic principles, Medicinal Chemistry examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators. Next, receptors associated with cellular organelles (mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and exogenous pathogens (viruses, bacteria) are examined. Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered.

There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modeling techniques, high throughput screening, neuropharmacology and genetics/genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized. Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated and ligand-gated ion channels has been incorporated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well as treatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book's appeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level.

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Editorial Reviews

From the Publisher
"The third edition of this popular textbook remains unique, authoritative, comprehensive and readable. Through a systematic organization of drug targets, all the important human disease and major categories of drugs are discussed providing insights into drug mechanisms and approaches to drug discovery. I highly recommend this book."—Doody's

"...recognized for its readability and clear-honed pitch, as the authors delve deeply into the mechanical specifics of how drugs take action on the human body."—The Electric Review

Doody's Review Service
Reviewer: Thomas L. Pazdernik, PhD (University of Kansas Medical Center)
Description: This medicinal chemistry textbook provides introductory information on basic molecular principles of drug design followed by applications of medicinal chemistry from a target-centered viewpoint. This third edition not only updates new information but focuses on the prominent role of molecular modeling, high throughput screening, and genomics on drug design and discovery.
Purpose: The purpose is to provide the core biochemical and molecular principles needed in an introductory medicinal chemistry course and then apply these principles towards understanding the mechanisms by which drugs affect specific targets and diseases. This is a very readable book that can be understood by a basic chemist or a clinical practitioner. The authors have done a remarkable job of preparing a textbook that is comprehensive, authoritative, and readable.
Audience: This book is valuable for students and scientists in chemistry, pharmacy, and medicine. Since Donald Weaver is both a medicinal chemist and clinical neurologist and Thomas Norgrady is a retired professor, this book has perspectives and insights that are unique and often missing from many medicinal chemistry textbooks.
Features: The first part is devoted to basic principles with a chapter on structure and properties of drug molecules, a chapter on structure and properties of receptors, and a chapter on designing drug molecules to fit receptors. Part two deals with specific drug targets including: neurotransmitters; hormones; immunomodulators; endogenous cellular structures such as ion channels, lipid membranes, transporters, cytoplasmic organelles and the nucleus; endogenous macromolecules such as proteins, lipids, carbohydrates and nucleic acids; and exogenous pathogens and toxins such as prions, viruses, bacteria, fungi, and parasites. Most chapters have a newly added feature entitled Clinical-Molecular Interface that highlights specific diseases such as collagen diseases or pneumonia. This edition also highlights the numerous advances that have been accomplished in developing drugs that treat nervous system and immunological diseases. The appendix provides a list of drugs arranged by pharmacological activity.
Assessment: The third edition of this popular textbook remains unique, authoritative, comprehensive and readable. Through a systematic organization of drug targets, all the important human disease and major categories of drugs are discussed providing insights into drug mechanisms and approaches to drug discovery. I highly recommend this book.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780195104561
  • Publisher: Oxford University Press, USA
  • Publication date: 10/1/2003
  • Edition description: REV
  • Edition number: 3
  • Pages: 672
  • Sales rank: 1,286,891
  • Product dimensions: 9.10 (w) x 6.40 (h) x 1.20 (d)

Meet the Author

Concordia University (Emeritus)

Dalhousie University

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Table of Contents

Part A. General Molecular Principles of Drug Design
1. Basic Principles of Drug Design I - Drug Molecules: Structure and Properties
2. Basic Principles of Drug Design II: Receptors: Structures and Properties
3. Basic Principles of Drug Design III: Designing Drug Molecules to Fit Receptors
Part B: Biochemical Considerations in Drug Design
4. Messenger Targets for Drug Action I: Neurotransmitters and Their Receptors
5. Messenger Targets for Drug Action II: Hormones and Their Receptors
6. Messenger Targets for Drug Action III: Immunomodulators and Their Receptors
7. Nonmessenger Targets for Drug Action I: Endogenous Cellular Structures
8. Nonmessenger Targets for Drug Action II: Endogenous Macromolecules
9. Nonmessenger Targets for Drug Action III: Exogenous "Nonself" Pathogens
Appendix A: Drugs Arranged by Pharmacologic Activity

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