Medicinal Natural Products: A Biosynthetic Approach / Edition 3

Medicinal Natural Products: A Biosynthetic Approach / Edition 3

by Paul M. Dewick
     
 

Medicinal Natural Products: A Biosynthetic Approach, Third Edition, provides a comprehensive and balanced introduction to natural products from a biosynthetic perspective, focusing on the metabolic sequences leading to various classes of natural products. The book builds upon fundamental chemical principles and guides the reader through a wealth of diverse natural… See more details below

Overview

Medicinal Natural Products: A Biosynthetic Approach, Third Edition, provides a comprehensive and balanced introduction to natural products from a biosynthetic perspective, focusing on the metabolic sequences leading to various classes of natural products. The book builds upon fundamental chemical principles and guides the reader through a wealth of diverse natural metabolites with particular emphasis on those used in medicine.

Product Details

ISBN-13:
9780470741672
Publisher:
Wiley
Publication date:
03/17/2009
Edition description:
New Edition
Pages:
550
Product dimensions:
7.30(w) x 9.60(h) x 1.40(d)

Meet the Author

Table of Contents

1About this Book, and How to Use it1
2Secondary Metabolism: The Building Blocks and Construction Mechanisms7
Primary and Secondary Metabolism7
The Building Blocks8
The Construction Mechanisms12
Some Vitamins Associated with the Construction Mechanisms30
3The Acetate Pathway: Fatty Acids and Polyketides35
Saturated Fatty Acids36
Unsaturated Fatty Acids40
Acetylenic Fatty Acids47
Branched-Chain Fatty Acids48
Prostaglandins51
Thromboxanes58
Leukotrienes58
Aromatic Polyketides60
Macrolides and Polyethers92
Cyclization Through Diels-Alder Reactions111
Genetic Manipulation of the Acetate Pathway114
4The Shikimate Pathway: Aromatic Amino Acids and Phenylpropanoids121
Aromatic Amino Acids and Simple Benzoic Acids121
Cinnamic Acids130
Lignans and Lignin132
Phenylpropenes135
Benzoic Acids from C[subscript 6]C[subscript 3] Compounds141
Coumarins142
Styrylpyrones147
Flavonoids and Stillbenes149
Flavonolignans151
Isoflavonoids154
Terpenoid Quinones158
5The Mevalonate and Deoxyxylulose Phosphate Pathways: Terpenoids and Steroids167
Hemiterpenes (C[subscript 5])172
Monoterpenes (C[subscript 10])172
Irregular Monoterpenes186
Iridoids (C[subscript 10])187
Sesquiterpenes (C[subscript 15])191
Diterpenes (C[subscript 20])203
Sesterterpenes (C[subscript 25])212
Triterpenes (C[subscript 30])212
Tetraterpenes (C[subscript 40])226
Higher Terpenoids231
Steroids232
6Alkaloids291
Alkaloids Derived from Ornithine292
Alkaloids Derived from Lysine307
Alkaloids Derived from Nicotinic Acid311
Alkaloids Derived from Tyrosine315
Alkaloids Derived from Tryptophan346
Alkaloids Derived from Anthranilic Acid376
Alkaloids Derived from Histidine379
Alkaloids Derived by Amination Reactions381
Purine Alkaloids394
7Peptides, Proteins, and Other Amino Acid Derivatives405
Peptides and Proteins405
Ribosomal Peptide Biosynthesis407
Peptide Hormones410
Nonribosomal Peptide Biosynthesis421
Peptide Antibiotics423
Peptide Toxins433
Modified Peptides: Penicillins, Cephalosporins, and Other [beta]-Lactams422
Cyanogenic Glycosides455
Glucosinolates457
Cysteine Sulphoxides460
8Carbohydrates465
Monosaccharides465
Oligosaccharides469
Polysaccharides473
Aminosugars477
Aminoglycosides478
Index487

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