Medicinal Natural Products: A Biosynthetic Approach / Edition 3

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Medicinal Natural Products: A Biosynthetic Approach, Third Edition, provides a comprehensive and balanced introduction to natural products from a biosynthetic perspective, focusing on the metabolic sequences leading to various classes of natural products. The book builds upon fundamental chemical principles and guides the reader through a wealth of diverse natural metabolites with particular emphasis on those used in medicine.

"...a concise and informative textbook providing a comprehensive introduction to natural products in medicine from a biosynthetic point of view."

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Editorial Reviews

From the Publisher
"Students should be empowered for a deductive analysis of the presented substances." (Arzneimittelforschung, December 2009)

"This new edition is an excellent text that is unrivaled in both its scope and overall coverage of natural products biosynthesis." (Journal of Medicinal Chemistry, August 2009)

"There is no question that this is the best book available on the biosynthesis and bio-organic chemistry of medicinally important natural products." (Education in Chemistry, September 2009)

A text for an undergraduate pharmacy course reflecting the recent tendency to teach about pharmaceuticals derived from plants, antibiotics from microbials, and steroidal and prostanoid drugs from animals as a single subject. Pivots on the notion of biosynthesis as the metabolic sequence leading to various selected classes of natural products. Applies fundamental chemical principles and shows the relationships between the various structures encountered in nature to provide a rationale for natural products. Seeks more to engender an understanding of the structures and how living organisms put them together than to transfer a mass of descriptive information. The material is ample and diverse enough to be selected from to tailor a specific course. References are not only chapter-specific, but classified into the several compounds discussed. Annotation c. by Book News, Inc., Portland, Or.
From The Critics
This comprehensive guide to pharmacognosy, the scientific study of natural health remedies from herbs, animal products, and inorganic materials, is directed primarily toward undergraduate students— whether or not such material is integrated with traditional pharmacy courses. Dewick (pharmaceutical sciences, U. of Nottingham, UK) provides a foundation in natural product chemistry/phytochemistry and nomenclature before proceeding to coverage of the primary and secondary metabolism of the reactions of these diverse substances; and the pathways involved in the biosynthesis of several classes of popular natural medicines represented by echinacea, kava, feverfew, taxol, alkaloids, garlic, and various vitamins. The chapters include molecular structure diagrams, boxed material, and further reading. Annotation c. Book News, Inc., Portland, OR (
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Product Details

  • ISBN-13: 9780470741672
  • Publisher: Wiley
  • Publication date: 3/17/2009
  • Edition description: New Edition
  • Edition number: 3
  • Pages: 550
  • Sales rank: 1,240,929
  • Product dimensions: 7.30 (w) x 9.60 (h) x 1.40 (d)

Table of Contents

1 About this Book, and How to Use it 1
2 Secondary Metabolism: The Building Blocks and Construction Mechanisms 7
Primary and Secondary Metabolism 7
The Building Blocks 8
The Construction Mechanisms 12
Some Vitamins Associated with the Construction Mechanisms 30
3 The Acetate Pathway: Fatty Acids and Polyketides 35
Saturated Fatty Acids 36
Unsaturated Fatty Acids 40
Acetylenic Fatty Acids 47
Branched-Chain Fatty Acids 48
Prostaglandins 51
Thromboxanes 58
Leukotrienes 58
Aromatic Polyketides 60
Macrolides and Polyethers 92
Cyclization Through Diels-Alder Reactions 111
Genetic Manipulation of the Acetate Pathway 114
4 The Shikimate Pathway: Aromatic Amino Acids and Phenylpropanoids 121
Aromatic Amino Acids and Simple Benzoic Acids 121
Cinnamic Acids 130
Lignans and Lignin 132
Phenylpropenes 135
Benzoic Acids from C[subscript 6]C[subscript 3] Compounds 141
Coumarins 142
Styrylpyrones 147
Flavonoids and Stillbenes 149
Flavonolignans 151
Isoflavonoids 154
Terpenoid Quinones 158
5 The Mevalonate and Deoxyxylulose Phosphate Pathways: Terpenoids and Steroids 167
Hemiterpenes (C[subscript 5]) 172
Monoterpenes (C[subscript 10]) 172
Irregular Monoterpenes 186
Iridoids (C[subscript 10]) 187
Sesquiterpenes (C[subscript 15]) 191
Diterpenes (C[subscript 20]) 203
Sesterterpenes (C[subscript 25]) 212
Triterpenes (C[subscript 30]) 212
Tetraterpenes (C[subscript 40]) 226
Higher Terpenoids 231
Steroids 232
6 Alkaloids 291
Alkaloids Derived from Ornithine 292
Alkaloids Derived from Lysine 307
Alkaloids Derived from Nicotinic Acid 311
Alkaloids Derived from Tyrosine 315
Alkaloids Derived from Tryptophan 346
Alkaloids Derived from Anthranilic Acid 376
Alkaloids Derived from Histidine 379
Alkaloids Derived by Amination Reactions 381
Purine Alkaloids 394
7 Peptides, Proteins, and Other Amino Acid Derivatives 405
Peptides and Proteins 405
Ribosomal Peptide Biosynthesis 407
Peptide Hormones 410
Nonribosomal Peptide Biosynthesis 421
Peptide Antibiotics 423
Peptide Toxins 433
Modified Peptides: Penicillins, Cephalosporins, and Other [beta]-Lactams 422
Cyanogenic Glycosides 455
Glucosinolates 457
Cysteine Sulphoxides 460
8 Carbohydrates 465
Monosaccharides 465
Oligosaccharides 469
Polysaccharides 473
Aminosugars 477
Aminoglycosides 478
Index 487
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