Membrane-Active Peptides: Methods and Results on Structure and Function

by Miguel A. R. B. Castanho (Editor)

Overview

Among all sectors of peptide science, membrane-active peptidology is probably the most promising and fast growing. Membrane-active peptides are a challenge for their involvement in highly heterogeneous systems, the biological membranes. Surface chemistry at the lipid water interface and molecular events in a confined medium such as the lipid bilayer (not exactly 2D, not exactly 3D) are quite appealing, almost irresistible mainly to physical chemists and physical biochemists, whether to study structural aspects of peptide conformation and supra-molecular organization of peptides and/or lipids, or the thermodynamics and kinetics associated to the molecular dynamics of microheterogenous systems. The evolution of biophysical techniques with constant improvement in time and space resolution enables increasingly detailed insights.

Product Details

ISBN-13:	9780972077453
Publisher:	International University Line
Publication date:	10/31/2009
Edition description:	INTERNATIONAL UNIV LINE
Pages:	635
Product dimensions:	6.30(w) x 9.10(h) x 1.70(d)

What People are Saying About This

David Andreu

A timely, comprehensive, authoritative survey of the ever-expanding world of membrane-active peptides, this book will be of interest not only for experts in the various fields (biochemistry, biophysics, microbiology, and therapeutics) where peptides meet membranes, but for a more general reader looking for a reliable introduction to this exciting area. A well-known leader in the field, Prof. Castanho has assembled a distinguished team of specialists who cover practically all aspects of the subject, at both theoretical and experimental levels, with strong emphasis on antimicrobial and cell-penetrating peptides. Carefully written and edited, this volume is likely to become a unique reference on membrane-active peptides for many years to come. (David Andreu, Scientific Affairs Officer of the European Peptide Society, Professor of Chemistry, Universitat Pompeu Fabra, Barcelona, Spain)

Joel Schneider

Professor Castanho, a leader in the field of peptide-membrane interactions has assembled a comprehensive collection of chapters that defines the field. The biophysics that governs the interplay between peptides and membranes is examined via in-depth discussions of the tools used to study these events and biological examples in which these processes play key roles. The book is assembled in a logical manner beginning with chapters that critically examine computational and the biophysical methods used to study peptide-membrane interactions. Light scattering, SPR, NMR, AFM, laser scanning microscopy, and fluorescence microscopy techniques, amongst others are highlighted for their ability to shed light on the molecular interactions that govern these processes. Later chapters examine biological events in which peptides engage membranes, for example, the mechanisms of cell-penetrating peptides, antimicrobial peptides, and cyclotides. Professor Castanho has chosen significant, interesting and timely subject matter to exemplify the possible roles that membrane-active peptides can play not only in biology but also in the development of novel technology. The book is a useful field guide for those just entering the field as well as seasoned investigators interested in applying new techniques to on-going problems. (Joel Schneider, Editor in Chief, Biopolymers-Peptide Science, Professor of Chemistry and Biochemistry, University of Delaware, USA)