Membrane Microdomain Signaling: Lipid Rafts in Biology and Medicine / Edition 1

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Cutting-edge articles review our current understanding of lipid microdomain signaling mechanisms and their physiological and pathological importance. The book describes the role of lipid rafts in learning, memory, and cancer, presents the emerging evidence that lipid rafts play critical roles in signaling pathways and the regulation of synaptic function in the nervous system, and shows how alterations in lipid raft metabolism are implicated in the pathogenesis of neurodegenerative disorders. Techniques are also described for the isolation of lipid rafts, the analysis of the lipid and protein components of lipid rafts, the imaging of lipid rafts in living cells, and the analysis of signal transduction in lipid rafts.

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Editorial Reviews

Doody's Review Service
Reviewer: Celso Agner, MD, MS, MSc (Michigan Neurology Partners)
Description: The potential membrane effects on behavior have been proven in the past. This book addresses the membrane as the controller of cellular signaling.
Purpose: The purpose is to determine the nature of the lipid rafts in the determination of cell signaling.
Audience: Neuroscientists are the main targets for this book.
Features: The 10 chapters are written by 25 authors. The thrust of the book is to address the function of lipids in the transmission of signals from the extracellular environment to the internal cellular milieu. The incorporation of cholesterol particles in the membranes determines reproduction of genetic behaviors not previously imagined. There is also a direct relationship with specific membrane diseases that will potentially be managed by targeted therapy to the cellular membrane lipids.
Assessment: This is a good acquisition for general medical and neuroscience libraries.
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Product Details

  • ISBN-13: 9781617375156
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 11/5/2010
  • Edition description: Softcover reprint of hardcover 1st ed. 2005
  • Edition number: 1
  • Pages: 214
  • Product dimensions: 9.00 (w) x 6.00 (h) x 0.52 (d)

Table of Contents

From Intramolecular Asymmetries to Raft Assemblies: A Short Guide for the Puzzled in Lipidomics
Ephraim Yavin and Annette Brand

Regulatory Aspects of Membrane Microdomain (Raft) Dynamics in Live Cells: A Biophysical Approach
János Matkó and János Szöllosi

Lipid Raft Membrane Skeletons
Elizabeth J. Luna, Thomas Nebl, Norio Takizawa, and Jessica L. Crowley

Role of Cholesterol in Membrane Microdomain Signaling
Christopher J. Fielding

Raft Lipid Metabolism in Relation to Alkyl-Lysophospholipid-Induced Apoptosis
Arnold H. van der Luit, Marcel Verheij, and Wim J. van Blitterswijk

Role of Lipid Rafts in Signal Transduction and Synaptic Plasticity of Neural Cells
Markus Delling and Melitta Schachner

Role of Rafts in Virus Fusion and Budding
Wu Ou and Jonathan Silver

Alterations in Raft Lipid Metabolism in Aging and Neurodegenerative Disorders
Mark P. Mattson, Roy G. Cutler, and Norman J. Haughey

Caveolin and Cancer: A Complex Relationship
Mordechai Liscovitch, Elke Burgermeister, Neeru Jain, Dana Ravid, Maria Shatz, and Lilach Tencer

Dietary Modulation of Lipid Rafts: Implications for Disease Prevention and Treatment
Mark P. Mattson


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