Membrane Physiopathology

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Overview

The need for publishing a comprehensive review of a number of different membrane pathologies of muscle and non-muscle cells in illnesses ranging from diabetes to heart disease and cancer lies on the fact that there are several books focussing on abnormal membrane behavior. Since the cell membrane is the critical outer barrier of a cell, this membrane could be the first structure to be affected in some diseases. Research at the cellular level is advancing at a very rapid rate. We can now address questions such as:...
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Paperback (Softcover reprint of the original 1st ed. 1994)
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Overview

The need for publishing a comprehensive review of a number of different membrane pathologies of muscle and non-muscle cells in illnesses ranging from diabetes to heart disease and cancer lies on the fact that there are several books focussing on abnormal membrane behavior. Since the cell membrane is the critical outer barrier of a cell, this membrane could be the first structure to be affected in some diseases. Research at the cellular level is advancing at a very rapid rate. We can now address questions such as: "How and by what mechanism does underlying membrane ion channel and receptor dysfunction lead to abnormal cell function?" and "What substances cause dysfunction of specific ion channels or receptors?". Such questions bring together the microscopic world of the cell with the macroscopic manifestation of disease. We believe that a treatise such as this one would help researchers, physicians, and students to better understanding the relationship between cell membrane dysfunction and abnormal function of the cell and tissue.
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Product Details

  • ISBN-13: 9781461361213
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 12/31/2012
  • Series: Developments in Cardiovascular Medicine Series , #159
  • Edition description: Softcover reprint of the original 1st ed. 1994
  • Edition number: 1
  • Pages: 431
  • Product dimensions: 6.14 (w) x 9.21 (h) x 0.89 (d)

Table of Contents

List of contributors
Preface
Introduction
1 Hamster cardiomyopathy: new insights in the pathogenesis of this hereditary disease 1
2 Membrane physiopathology in hereditary cardiomyopathy 13
3 Restructuring of sarcoplasmic reticular membrane during the development of heart disease 25
4 Membrane disfunction and abnormal spontaneous activity: a study in explanted cardiac cells 47
5 Ionic channels involved in the myocardial response to metabolic stress 71
6 Role of Na/H exchanger and [actual symbol not reproducible] in electrophysiological responses to acidosis and realkalization in isolated guinea pig ventricular myocytes 101
7 Cardiac cell lines: electrophysiological properties and implications in cardiac disease 115
8 Fetal-like slow Na[superscript +] channels in Duchenne muscular dystrophy 123
9 Some smooth muscles possess fast sodium channels 133
10 Regulation of Ca[superscript 2+] channels in vascular smooth muscle cells by cyclic nucleotides and by G-protein gating 155
11 Role of the R-type Ca[superscript 2+] channel in cardiovascular physiopathology 173
12 Passive endothelial transport: studies in experimental arterial hypertension, diabetes mellitus and chronic renal failure 185
13 Pharmacology of the human precursors of endothelin: role of functional receptors and endothelin-converting enzyme 207
14 Carboxyl methylation of proteins in kidney membranes: implications in the repair of damaged proteins and in signal transduction 227
15 Transport systems in kidney basolateral membrane: pathophysiologic implications 249
16 Effect of insulin and glucagon on hepatocellular alanine uptake in normal and streptozocin-induced diabetic rats 271
17 The modulation of membrane ion movements by cholesterol 291
18 Human intestinal brush border membrane hydrolases 319
19 Cytosolic Ca[superscript 2+] homeostasis in human HeLa carcinoma cells 343
20 Inositol 1,4,5-Trisphosphate Analogs: a new class of therapeutic agents 359
21 The role of plasma membrane in the pathogenesis of osteoblastic metastasis 375
22 Receptors for vasoactive peptides and their implications in physiopathology 387
Index 403
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