Membrane Physiopathology / Edition 1

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The need to publish a comprehensive review of a number of different membrane pathologies of muscle and non-muscle cells in illnesses ranging from diabetes to heart disease and cancer lies in the fact that there are several books focusing on abnormal membrane behavior. Since the cell membrane is the critical outer barrier of a cell, this membrane could be the first structure to be affected in some diseases. Research at the cellular level is advancing at a very rapid rate. We can now address questions such as: 'How and by what mechanism does underlying membrane ion channel and receptor dysfunction lead to abnormal cell function?' and 'What substances cause dysfunction of specific ion channels or receptors?' Such questions bring together the microscopic world of the cell with the macroscopic manifestation of disease. A treatise such as this will help researchers, physicians, and students to better understand the relationship between cell membrane dysfunction and abnormal function of the cell and tissue.

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Product Details

  • ISBN-13: 9780792330622
  • Publisher: Springer US
  • Publication date: 9/5/2007
  • Series: Developments in Cardiovascular Medicine Series , #159
  • Edition description: 1994
  • Edition number: 1
  • Pages: 406
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.94 (d)

Table of Contents

Preface; G. Bkaily. Introduction; G. Bkaily. 1. Hamster cardiomyopathy: new insights in the pathogenesis of this hereditary disease; G. Jasmin, L. Proschek. 2. Membrane physiopathology in hereditary cardiomyopathy; G. Bkaily, D. Jacques. 3. Restructuring of sarcoplasmic reticular membrane during the development of heart disease; N.S. Dhalla, N. Afzal, H. Rupp, N. Takeda, M. Nagano. 4. Membrane dysfunction and abnormal spontaneous activity: a study in explanted cardiac cells; O.F. Schanne, J. Qu, G.E. Haddad, E. Ruiz-Petrich. 5. Ionic channels involved in the myocardial response to metablic stress; E. Ruiz-Petrich, F. deLorenzi, S. Cai, O.F. Schanne. 6. Role of Na/H exchanger and [Ca2+]i in electrophysiological responses to acidosis and realkalization in isolated guinea pig ventricular myocytes; M.F. Moffat, J. Duan, C.A. Ward. 7. Cardiac cell lines: electrophysiological properties and implications in cardiac disease; A. Sculptoreanu. 8. Fetal-like slow Na+ channels in Duchenne muscular dystrophy; G. Bkaily, A. Sculptoreanu, G. Jasmin. 9. Some smooth muscles possess fast sodium channels; N. Sperelakis, Z. Xiong, Y. Inoue, Y. Ohya, K. Shimmamura, D. Bielefeld. 10. Regulation of Ca2+ channels in vascular smooth muscle cells by cyclic nucleotides and by G-protein gating; N. Sperelakis, Z. Xiong, J. Lorenz. 11. Role of the R-type Ca2+ channel in cardiovascular physiopathology; G. Bkaily, P. d'Orléns-Juste, R. Naik, D. Economos, S. Wang, E. Abdulnour, J.-L. Ardilouze. 12. Passive endothelial transport: studies in experimental arterial hypertension, diabetes mellitus and chronic renal failure; G.E. Plante, M. Chakir. 13. Pharmacology of the human precursors of endothelin: role of functional receptors and endothelin-converting enzyme; P. d'Orléans-Juste, S. Télémaque. 14. Carboxyl methylation of proteins in kidney membranes: implications in the repair of damaged proteins and in signal transduction; D. Boivin, D. Gingras, R. Béliveau. 15. Transport systems in kidney basolateral membrane: pathophysiologic implications; A. Sahai, P.K. Ganguly. 16. Effect of insulin and glucagon on hepaellular alanine uptake in normal and streptozocin-induced diabetic rates; A.B. Bikhazi, G.E. Haddad, H.M. Alloush, F.H. Uthman, N.A. Fakruddin, M. El-Kasti. 17. The modulation of membrane ion movements by cholesterol; K. Liu, G.N. Pierce. 18. Human intestinal brush border membrane hydrolases; D. Menard, J.F. Beaulieu. 19. Cytosolic Ca2+ homeostasis in human HeLa carcinoma cells; R. Sauvé, R. Wang, L. Garneau. 20. Inositol 1,4,5-Triphosphate Analogs: a new class of therapeutic agents; D.E. Richard, S. Bernier, G. Guillemette. 21. The role of plasma membrane in the pathogenesis of osteoblastic metastasis; M. Koutsilieris, P.A. Rogers. 22. Receptors for vasoactive peptides and their implications in physiopathology; D. Regoli, A. Claing, P. d'Orléans-Juste. Index.

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