Meningococcal Disease / Edition 1

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Andrew Pollard and Martin Maiden bring together a panel of leading authorities to produce a comprehensive, interdisciplinary survey of recent advances and knowledge about meneigococcal disease. The review and methods-based chapters collected here provide essential information for diagnosis in the clinical microbiology laboratory, isolate characterization, clinical management, and control of meningococcal disease. They also examine the immunopathological mechanisms occurring in the acutely ill, host-pathogen interactions, and the possible components of meningococcus responsible for virulence. Meningococcal Disease: Methods and Protocols integrates the basic science, clinical, and epidemiological aspects of this terrible infectious disease to promote the deeper understanding needed to identify novel targets for therapeutic interventions and vaccines.
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Editorial Reviews

From the Publisher
"The editors invited the most skilled specialists in the world, 95 contributors, to share with the readers their knowledge of many aspects of meningococcal disease....The book is a brilliant and comprehensive review of the most recent methods for investigation of meningococcal disease and Neisseria meningitidis. It also includes detailed protocols, which should contribute to standardization of meningococcal investigation in the whole world and should allow different laboratories to obtain comparable results. The book is an excellent source of references. It is highly recommended to microbiologists, epidemiologists and clinicians dealing with meningococcal disease." - Folia Microbiologia

"The book claims to be "a comprehensive and authoritative review of meningococcal biology", "an interdisciplinary survey of recent advances and knowledge", to give "cutting-edge methods for the diagnosis, epidemiology and treatment of meningococcal disease", and it fully meets these standards. It has achieved its aim to join basic science with epidemiological and clinical aspects of the disease." - International Journal of Medical Microbiology

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Product Details

  • ISBN-13: 9781617372216
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 11/9/2010
  • Series: Methods in Molecular Medicine Series , #67
  • Edition description: Softcover reprint of hardcover 1st ed. 2001
  • Edition number: 1
  • Pages: 721
  • Product dimensions: 9.00 (w) x 6.00 (h) x 1.63 (d)

Table of Contents

Microbiology and Laboratory Diagnosis
Keith Cartwright

Isolation, Culture, and Identification of Meningococci from Clinical Specimens
Per Olcén and Hans Fredlund

PCR Diagnosis
Malcolm Guiver and Ray Borrow

Detection of Meningococcal Antigen by Latex Agglutination
Michael A. Sobanski, Rosemary A. Barnes, and W. Terence Coakley

Meningococcal Serology
Stephen J. Gray, Ray Borrow, and Edward B. Kaczmarski

Antibiotic Susceptibility Testing
Colin Block

Molecular Approach for the Study of Penicillin Resistance in Neisseria Meningitidis
Luisa Arreaza and Julio A. Vázquez

Overview: Epidemiology, Surveillance and Population Biology
Martin C. J. Maiden and Norman T. Begg

Serological Characterization
Betsy Kuipers, Germie van den Dobbelsteen, Elisabeth Wedege, and Loek van Alphen

Pulsed-Field Gel Electrophoresis
Mark Achtman and Giovanna Morelli

Nucleotide Sequencing of Antigen Genes of Neisseria Meningitidis
Rachel Urwin

Multi-Locus Sequence Typing
Keith A. Jolley

Capsular Operons
Ulrich Vogel, Heike Claus, and Matthias Frosch

Molecular Analysis of the Meningococcal LPS Expression
Michael P. Jennings, Andrew W. Berrington, and E. Richard Moxon

Genome Sequencing and Annotation
Alex C. Jeffries, Nigel J. Saunders, and Derek W. Hood

Representational Difference Analysis
Lucas D. Bowler, Aldert Bart, and Arie van der Ende

Managing Outbreaks: The Public Health Response
James M. Stuart

Global Trends in Meningococcal Disease
Dominique A. Caugant

Epidemiology, Surveillance, and Population Biology: Carriage Studies
Keith Cartwright

Surveillance of Meningococcal Disease in Europe
Norman Noah

Global Surveillance for Meningococcal Disease
Nancy E.Rosenstein

Epidemiology of Meningococcal Disease in North America
Andrew J. Pollard, David Scheifele, and Nancy Rosenstein

Computational Methods for Meningococcal Population Studies
Keith A. Jolley and Rachel Urwin

Clinical Studies and Host-Pathogen Interactions
F. Andrew I. Riordan and Andrew J. Pollard

Clinical Scoring Systems in Meningococcal Disease
Marino Festa and Bert Derkx

Quantitative Detection of Bacterial Lipopolysaccharides in Clinical Specimens
Petter Brandtzaeg, Reidun Øvstebø, and Peter Kierulf

Isolation and Analysis of Radiolabeled Meningococcal Endotoxin
Peter C. Giardina, Jerrold A. Weiss, Brad W. Gibson, and Michael A. Apicella

Cytokine Measurement In Vivo and In Vitro
Marcel van Deuren and Petter Brandtzaeg

Cytokine Bioassays
Nina-Beate Liabakk, Anders Waage, Egil Lien, Jørgen Stenvik, and Terje Espevik

Molecular Analysis of Gene-Polymorphisms Affecting the Host Response to Infection
Rudi G. J. Westendorp and Tom W.J. Huizinga

Coagulation Studies
Jan A. Hazelzet, C. Erik Hack, and Ronald de Groot

Complement Pathways and Meningococcal Disease: Diagnostic Aspects
Anders G. Sjöholm, Lennart Truedsson, and Jens C. Jensenius

Evaluation of New Treatments for Meningococcal Disease
Simon Nadel, Iain Macintosh, and Michael Levin

Studies on the Effect of Neisserial Porins on Apoptosis of Mammalian Cells
Paola Massari and Lee M. Wetzler

Molecular Recognition Mechanisms of Meningococci: Identifying Receptor-Ligand Pairs Involved in Microbe-Host Interactions
Mumtaz Virji and Laura Serino

Experimental Nasopharyngeal Colonization by Neisseria Meningitidis Using Explant Organ Culture
Robert C. Read and Linda Goodwin

Invasion of the Central Nervous System by Neisseria Meningitidis
Colin Tinsley and Xavier

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