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Meta-Analysis, Decision Analysis, and Cost-Effectiveness Analysis: Methods for Quantitative Synthesis in Medicine / Edition 2

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Overview

When formulating policy recommendations in medicine, the need for a synthesis of information to evaluate effectiveness and costs is irrefutable. This book describes meta-analysis, decision analysis, and cost-effectiveness analysis as conceptually related, quantitative methods for combining information to arrive at a summary conclusion. The information derived from appropriate use of these methods would foster rational decision-making based on systematic use of the information we already have. The book describes how to design and conduct these three types of studies and how to interpret their results. It presents sufficient detail on the practical aspects of the application of the methods so that even a novice could do a simple analysis knowing little more than what is in the book. Those who do not plan to carry out these types of studies themselves will profit from more detailed knowledge about how such studies are properly done. Policy-makers without direct research experience will learn how better to utilize data from the three types of studies taking into account their limitations, which are discussed fully.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Patricia Langenberg, PhD (University of Maryland at Baltimore School of Medicine)
Description: This book is a comprehensive review of meta-analysis, decision analysis, and cost-effectiveness analysis as quantitative methods for the synthesis of research information in medicine.
Purpose: The purpose is to describe methods of meta-analysis, decision analysis, and cost effectiveness analysis in order to summarize information from the literature in medicine. The objectives are particularly worthy in that the subjects are controversial and books on the topic have heretofore been primarily statistical or geared toward literature in fields other than medicine.
Audience: The book is very well written and accessible to nearly anyone in the medical field who would contemplate either reading about or carrying out meta-analysis, decision analysis, or cost-effectiveness analysis. The author is highly knowledgeable about her subject.
Features: All stages of meta-analysis are covered: data retrieval/collection, detection of bias, statistical analysis, exploration of heterogeneity. Many relevant examples from the field of medicine are cited and examples of the statistical methods are provided. More important, space is devoted to the difficulties of identifying the 'fugitive' studies that may introduce serious bias (publication bias) if not included, since they are more likely to have negative results. Decision analysis methods are also described, including identification of the problem and its components structuring decision trees, estimation of probabilities, and sensitivity analysis. Decision analysis is described as the cornerstone of cost effectiveness analysis with the addition of cost data, identification of outcomes, and choice of cost-benefit function.
Assessment: This book is very well written, easy to understand and apply, with excellent relevant examples. It is the most comprehensive and accessible book in this field.
From The Critics
Reviewer: Patricia Langenberg, PhD(University of Maryland at Baltimore School of Medicine)
Description: This book is a comprehensive review of meta-analysis, decision analysis, and cost-effectiveness analysis as quantitative methods for the synthesis of research information in medicine.
Purpose: The purpose is to describe methods of meta-analysis, decision analysis, and cost effectiveness analysis in order to summarize information from the literature in medicine. The objectives are particularly worthy in that the subjects are controversial and books on the topic have heretofore been primarily statistical or geared toward literature in fields other than medicine.
Audience: The book is very well written and accessible to nearly anyone in the medical field who would contemplate either reading about or carrying out meta-analysis, decision analysis, or cost-effectiveness analysis. The author is highly knowledgeable about her subject.
Features: All stages of meta-analysis are covered: data retrieval/collection, detection of bias, statistical analysis, exploration of heterogeneity. Many relevant examples from the field of medicine are cited and examples of the statistical methods are provided. More important, space is devoted to the difficulties of identifying the 'fugitive' studies that may introduce serious bias (publication bias) if not included, since they are more likely to have negative results. Decision analysis methods are also described, including identification of the problem and its components structuring decision trees, estimation of probabilities, and sensitivity analysis. Decision analysis is described as the cornerstone of cost effectiveness analysis with the addition of cost data, identification of outcomes, and choice of cost-benefit function.
Assessment: This book is very well written, easy to understand and apply, with excellent relevant examples. It is the most comprehensive and accessible book in this field.
Michael M. Ravitch
This monograph describes three related methods on decision making and policy setting: decision analysis, cost-effectiveness analysis, and meta-analysis. The book educates the reader in appropriate use of these methods. "The purpose is to educate physicians (and others) on these three methodologies of medical decision making and policy formulation. These topics are current and important. No other book provides this joint presentation. The book effectively meets the author's objectives. "This book is appropriate for medical students (advanced), residents, physicians, and others interested in these methods, either to get a general overview or to get a basic formulation in the methods. The author is credible. "The major key references are cited. The table of contents and index are excellent. "This book provides an excellent readable general and technical introduction to these critically important methods in health care decision making and policy setting. It is useful as a monograph for individual use or as a text for courses or seminars.
Patricia Langenberg
This book is a comprehensive review of meta-analysis, decision analysis, and cost-effectiveness analysis as quantitative methods for the synthesis of research information in medicine. The purpose is to describe methods of meta-analysis, decision analysis, and cost effectiveness analysis in order to summarize information from the literature in medicine. The objectives are particularly worthy in that the subjects are controversial and books on the topic have heretofore been primarily statistical or geared toward literature in fields other than medicine. The book is very well written and accessible to nearly anyone in the medical field who would contemplate either reading about or carrying out meta-analysis, decision analysis, or cost-effectiveness analysis. The author is highly knowledgeable about her subject. All stages of meta-analysis are covered: data retrieval/collection, detection of bias, statistical analysis, exploration of heterogeneity. Many relevant examples from the field of medicine are cited and examples of the statistical methods are provided. More important, space is devoted to the difficulties of identifying the 'fugitive' studies that may introduce serious bias (publication bias) if not included, since they are more likely to have negative results. Decision analysis methods are also described, including identification of the problem and its components structuring decision trees, estimation of probabilities, and sensitivity analysis. Decision analysis is described as the cornerstone of cost effectiveness analysis with the addition of cost data, identification of outcomes, and choice of cost-benefit function. This book is very well written, easy to understand andapply, with excellent relevant examples. It is the most comprehensive and accessible book in this field.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780195133646
  • Publisher: Oxford University Press
  • Publication date: 10/14/1999
  • Series: Monographs in Epidemiology and Biostatistics Series , #31
  • Edition description: REV
  • Edition number: 2
  • Pages: 320
  • Sales rank: 707,051
  • Product dimensions: 9.30 (w) x 6.20 (h) x 1.30 (d)

Table of Contents

1. Introduction
2. Overview of the Methods
3. Planning the Study
4. Information Retrieval
5. Data Collection
6. Advanced Issues in Meta-Analysis
7. Statistical Methods in Meta-Analysis
8. Other Statistical Issues in Meta-Analysis
9. Complex Decision Problems
10. Estimating Probabilities
11. Utility Analysis
12. Advanced Cost Effectiveness Analysis
13. Utility and Cost-Utility Analysis
14. Exploring Heterogeneity
15. Sensitivity Analysis
16. Reporting Results
17. Limitations

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