Metabolic Activation of Drugs

Metabolic Activation of Drugs

by Lau, Linda Fung-Yee Ng
     
 

ISBN-10: 9622017444

ISBN-13: 9789622017443

Pub. Date: 11/19/1997

Publisher: Chinese University Press, The

?The metabolic activation of many drugs and xenobiotics in vivo is effected through the large family of cytochrome P450s enzymes that catalyse a diverse spectrum of reactions including the metabolism of both endogenous and exogenous compounds. There is considerable evidence suggesting that changes in P450 activities can affect the in vivo toxicity of drugs in both

Overview

?The metabolic activation of many drugs and xenobiotics in vivo is effected through the large family of cytochrome P450s enzymes that catalyse a diverse spectrum of reactions including the metabolism of both endogenous and exogenous compounds. There is considerable evidence suggesting that changes in P450 activities can affect the in vivo toxicity of drugs in both animals and humans. Oxidative metabolism by cytochrome P450 enzymes has been implicated in the pathogenesis of cancer, through the formation of toxic intermediates and carcinogenic metabolites are formed from drugs and xenobiotics. A marked overall increase in the metabolic activation of the commonly used analgesic agent, paracetamol, was found in patients with hepatocellular carcinoma, as indicated by a much higher percentage recovery of the oxidative metabolites cysteine and mercapturate conjugates, compared to healthy controls and patients with chronic hepatitis B infection. It was through that metabolic activation of some drugs and xenobiotics through the actions of specific cytochrome P450s may be enhanced in patients with hepatocellular carcinoma.

Product Details

ISBN-13:
9789622017443
Publisher:
Chinese University Press, The
Publication date:
11/19/1997
Series:
Young Scholars Dissertation Awards Series
Pages:
320
Product dimensions:
6.06(w) x 8.99(h) x 0.75(d)
Age Range:
18 Years

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