Metabolic Drug Interactions / Edition 1

Metabolic Drug Interactions / Edition 1

by Rene H. Levy Levy, Kenneth E. Thummel, William F. Trager
     
 

ISBN-10: 0781714419

ISBN-13: 9780781714419

Pub. Date: 03/28/2000

Publisher: Lippincott Williams & Wilkins

This volume brings together the large body of recent research on metabolic drug interactions and their relevance in the treatment of diseases. The book focuses on human metabolic enzyme systems that have been shown in vitro to be predictive of drug interactions. Major sections present information on specific therapeutic classes of drugs as substrates,

Overview

This volume brings together the large body of recent research on metabolic drug interactions and their relevance in the treatment of diseases. The book focuses on human metabolic enzyme systems that have been shown in vitro to be predictive of drug interactions. Major sections present information on specific therapeutic classes of drugs as substrates, inhibitors, and inducers of metabolic enzymes. Other chapters discuss the clinical and pharmacoeconomic implications of metabolic drug interactions and the significance of in vitro metabolic studies in new drug development.

Product Details

ISBN-13:
9780781714419
Publisher:
Lippincott Williams & Wilkins
Publication date:
03/28/2000
Pages:
793
Product dimensions:
8.40(w) x 11.94(h) x 1.58(d)

Table of Contents

Contributing Authorsix
Forewordxvii
Prefacexix
Acknowledgmentsxxi
Section IPrediction of Drug Interactions From In Vitro Studies: Basic Principles
1Metabolically-Based Drug-Drug Interactions: Principles and Mechanisms3
2From In Vitro to In Vivo: An Academic Perspective21
3Industrial Viewpoint: Application of In Vitro Drug Metabolism in Various Phases of Drug Development29
4Regulatory Viewpoint: Prediction of Drug Interactions from In Vitro Studies41
Section IIEnzymes and Transporters
5Cytochromes P450: Historical Overview51
6CYP1A61
7CYP2C75
8CYP2D687
9CYP2E195
10CYP3A115
11P-Glycoprotein135
12Other CYP: 2A6, 2B6, 4A145
13UDP-Glucuronosyltransferases161
14Glutathione S-Transferases175
15Sulfotransferases and Methyltransferases191
16Epoxide Hydrolases205
Section IIIDrugs As Substrates of Metabolic Enzymes Treatment of CNS Diseases
17Anticonvulsants217
18Antidepressants233
19Antipsychotics245
20Sedative-Hypnotic and Anxiolytic Agents259
21Volatile, Intravenous, and Local Anesthetics271
22Opioid Analgesics297
23Agents for the Treatment of Migraine, Parkinson's, and Alzheimer's Diseases321
Treatment of Cardiovascular Diseases
24Calcium Channel Blockers333
25[beta]-Adrenoreceptor Antagonists347
26Angiotensin II Antagonists, ACE Inhibitors, and Diuretics359
27Cholesterol-Lowering Agents and Cardiac Glycosides379
28Antiarrhythmics391
29Oral Anticoagulants403
Treatment of Microbial Diseases
30Oral Antifungals415
31Antivirals421
Treatment of Inflammation
32H[subscript 1]-Receptor Antagonists435
33Analgesics-Antipyretics447
34Nonsteroidal Antiinflammatory Drugs457
35Methylxanthines469
Treatment of Other Diseases
36H[subscript 2]-Antagonists, Proton-Pump Inhibitors, and Antiemetics483
37Immunosuppressive Agents499
38Estrogens and Progestins511
39Hypoglycemic Agents529
40Antineoplastic Agents545
Section IVDrugs as Inhibitors of Metabolic Enzymes Treatment of CNS Diseases
41Anticonvulsants557
42Antidepressants563
43Neuroleptics and Antipsychotics579
Treatment of Cardiovascular Diseases
44Calcium Channel Blockers591
45Antiarrythmics603
Treatment of Microbial Diseases
46Antimicrobials and Antiparasitics615
47Antifungals623
48Protease Inhibitors647
Treatment of Other Diseases
49H[subscript 2]-Receptor Antagonists653
50Inhibitors in the Diet: Grapefruit Juice-Drug Interactions661
Section VDrugs as Inducers of Metabolic Enzymes
51Phenobarbital, Phenytoin, and Carbamazepine673
52Rifampin, Dexamethasone, and Omeprazole691
53Isoniazid and Ethanol707
Section VIClinical Considerations
54Clinical and Pharmacoeconomic Significance of Metabolic Drug Interactions715
55Pharmacist Management of Drug Interactions723
56Interactions in the Elderly729
Section VIIAppendix
Other Drugs745
Drug Interaction Index749
General Index765

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