Metabolic Drug Interactions / Edition 1

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Overview

This volume brings together the large body of recent research on metabolic drug interactions and their relevance in the treatment of diseases. The book focuses on human metabolic enzyme systems that have been shown in vitro to be predictive of drug interactions. Major sections present information on specific therapeutic classes of drugs as substrates, inhibitors, and inducers of metabolic enzymes. Other chapters discuss the clinical and pharmacoeconomic implications of metabolic drug interactions and the significance of in vitro metabolic studies in new drug development.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Jean Deupree, PhD (University of Nebraska Medical Center)
Description: This book is a description of the different types of metabolic drug interactions which can occur and a discussion of how the different classes of drugs produce drug-drug interactions by either inducing or inhibiting metabolizing enzymes.
Purpose: The purpose is to organize and synthesize the literature on metabolic drug interactions and to present it for use by clinicians and scientists. Our knowledge of drug metabolism and the ability to predict and measure drug-drug interactions has been greatly enhanced over the last ten years. A book in which this knowledge is pulled together in a form that can be used by clinicians and scientists is greatly needed.
Audience: This book is written for clinicians and scientists. Pharmacists, scientists, and individuals in the pharmaceutical or drug-regulatory agencies will benefit the most from the details in the book. As the editors point out, it is extremely important to take into consideration the types of drug-drug interactions that can occur when prescribing drugs. Practitioners in most specialties and pharmacists would benefit from having this book in their reference library, however, the information may be more detailed than some practitioners desire. The information presented by world-wide experts is current but may be quickly outdated as new drugs are introduced into the market and our knowledge of drug metabolism increases.
Features: A description of the types of drug-drug interactions which can occur and the pharmacokinetic factors which effect these drug-drug interactions serves as the introduction. This is followed by descriptions of the different types of metabolizing enzymes. The book is then divided into two sections according to therapeutic class of drug. One section is on drugs as substrates for metabolizing enzymes and the other is drugs as inhibitors of metabolizing enzymes. Organizing the drugs according to classes makes it helpful for pharmacists or clinicians to look for a drug which is least likely to produce a drug interaction in a particular patient. This division ultimately proves confusing and there appears to be overlap. Still, there is an excellent cross referencing section at the end which makes it easy to find specific drug-drug interactions.
Assessment: The editors have presented an excellent compendium on what is currently known about metabolic drug interactions. This book is particularly helpful in assessing the significance of drug-metabolism, the types of drug-drug interactions that can occur, and the pharmacokinetic factors that can affect drug interactions.
Jean Deupree
This book is a description of the different types of metabolic drug interactions which can occur and a discussion of how the different classes of drugs produce drug-drug interactions by either inducing or inhibiting metabolizing enzymes. The purpose is to organize and synthesize the literature on metabolic drug interactions and to present it for use by clinicians and scientists. Our knowledge of drug metabolism and the ability to predict and measure drug-drug interactions has been greatly enhanced over the last ten years. A book in which this knowledge is pulled together in a form that can be used by clinicians and scientists is greatly needed. This book is written for clinicians and scientists. Pharmacists, scientists, and individuals in the pharmaceutical or drug-regulatory agencies will benefit the most from the details in the book. As the editors point out, it is extremely important to take into consideration the types of drug-drug interactions that can occur when prescribing drugs. Practitioners in most specialties and pharmacists would benefit from having this book in their reference library, however, the information may be more detailed than some practitioners desire. The information presented by world-wide experts is current but may be quickly outdated as new drugs are introduced into the market and our knowledge of drug metabolism increases. A description of the types of drug-drug interactions which can occur and the pharmacokinetic factors which effect these drug-drug interactions serves as the introduction. This is followed by descriptions of the different types of metabolizing enzymes. The book is then divided into two sections according to therapeutic class of drug. Onesection is on drugs as substrates for metabolizing enzymes and the other is drugs as inhibitors of metabolizing enzymes. Organizing the drugs according to classes makes it helpful for pharmacists or clinicians to look for a drug which is least likely to produce a drug interaction in a particular patient. This division ultimately proves confusing and there appears to be overlap. Still, there is an excellent cross referencing section at the end which makes it easy to find specific drug-drug interactions. The editors have presented an excellent compendium on what is currently known about metabolic drug interactions. This book is particularly helpful in assessing the significance of drug-metabolism, the types of drug-drug interactions that can occur, and the pharmacokinetic factors that can affect drug interactions.
Booknews
This reference organizes and synthesizes the literature on metabolic drug interactions for use by clinicians and scientists. Organized into four sections, it presents the basic rules of interpretation of data from the academic, industrial, and regulatory perspectives; metabolic enzymes and transporters; drugs as substrates of metabolic enzymes, and as inhibitors of metabolic enzymes (both of which topics are arranged by therapeutic class<-->inflammation, central nervous system, cardiovascular, microbial, and other diseases); drugs as inducers of metabolic enzymes; and the identification of patients at special risk for drug interactions. Levy and the four other editors are professors in departments of pharmaceutics, medicinal chemistry, and clinical pharmacology at leading medical institutions in the U.S. and Germany. Annotation c. Book News, Inc., Portland, OR (booknews.com)

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780781714419
  • Publisher: Lippincott Williams & Wilkins
  • Publication date: 3/28/2000
  • Edition number: 1
  • Pages: 793
  • Product dimensions: 8.40 (w) x 11.94 (h) x 1.58 (d)

Table of Contents

Contributing Authors
Foreword
Preface
Acknowledgments
1 Metabolically-Based Drug-Drug Interactions: Principles and Mechanisms 3
2 From In Vitro to In Vivo: An Academic Perspective 21
3 Industrial Viewpoint: Application of In Vitro Drug Metabolism in Various Phases of Drug Development 29
4 Regulatory Viewpoint: Prediction of Drug Interactions from In Vitro Studies 41
5 Cytochromes P450: Historical Overview 51
6 CYP1A 61
7 CYP2C 75
8 CYP2D6 87
9 CYP2E1 95
10 CYP3A 115
11 P-Glycoprotein 135
12 Other CYP: 2A6, 2B6, 4A 145
13 UDP-Glucuronosyltransferases 161
14 Glutathione S-Transferases 175
15 Sulfotransferases and Methyltransferases 191
16 Epoxide Hydrolases 205
17 Anticonvulsants 217
18 Antidepressants 233
19 Antipsychotics 245
20 Sedative-Hypnotic and Anxiolytic Agents 259
21 Volatile, Intravenous, and Local Anesthetics 271
22 Opioid Analgesics 297
23 Agents for the Treatment of Migraine, Parkinson's and Alzheimer's Diseases 321
24 Calcium Channel Blockers 333
25 [beta]-Adenoreceptor Antagonists 347
26 Angiotensin II Antagonists, ACE Inhibitors, and Diuretics 359
27 Cholesterol-Lowering Agents and Cardiac Glycosides 379
28 Antiarrhythmics 391
29 Oral Anticoagulants 403
30 Oral Antifungals 415
31 Antivirals 421
32 H[subscript 1]-Receptor Antagonists 435
33 Analgesics-Antipyretics 447
34 Nonsteroidal Antiinflammatory Drugs 457
35 Methylxanthines 469
36 H[subscript 2]-Antagonists, Proton-Pump Inhibitors, and Antiemetics 483
37 Immunosuppressive Agents 499
38 Estrogens and Progestins 511
39 Hypoglycemic Agents 529
40 Antineoplastic Agents 545
41 Anticonvulsants 557
42 Antidepressants 563
43 Neuroleptics and Antipsychotics 579
44 Calcium Channel Blockers 591
45 Antiarrythmics 603
46 Antimicrobials and Antiparasitics 615
47 Antifungals 623
48 Protease Inhibitors 647
49 H[subscript 2]-Receptor Antagonists 653
50 Inhibitors in the Diet: Grapefruit Juice-Drug Interactions 661
51 Phenobarbital, Phenytoin, and Carbamazepine 673
52 Rifampin, Dexamethasone, and Omeprazole 691
53 Isoniazid and Ethanol 707
54 Clinical and Pharmacoeconomic Significance of Metabolic Drug Interactions 715
55 Pharmacist Management of Drug Interactions 723
56 Interactions in the Elderly 729
Other Drugs 745
Drug Interaction Index 749
General Index 765
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