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Doody's Review ServiceReviewer: Jean Deupree, PhD (University of Nebraska Medical Center)
Description: This book is a description of the different types of metabolic drug interactions which can occur and a discussion of how the different classes of drugs produce drug-drug interactions by either inducing or inhibiting metabolizing enzymes.
Purpose: The purpose is to organize and synthesize the literature on metabolic drug interactions and to present it for use by clinicians and scientists. Our knowledge of drug metabolism and the ability to predict and measure drug-drug interactions has been greatly enhanced over the last ten years. A book in which this knowledge is pulled together in a form that can be used by clinicians and scientists is greatly needed.
Audience: This book is written for clinicians and scientists. Pharmacists, scientists, and individuals in the pharmaceutical or drug-regulatory agencies will benefit the most from the details in the book. As the editors point out, it is extremely important to take into consideration the types of drug-drug interactions that can occur when prescribing drugs. Practitioners in most specialties and pharmacists would benefit from having this book in their reference library, however, the information may be more detailed than some practitioners desire. The information presented by world-wide experts is current but may be quickly outdated as new drugs are introduced into the market and our knowledge of drug metabolism increases.
Features: A description of the types of drug-drug interactions which can occur and the pharmacokinetic factors which effect these drug-drug interactions serves as the introduction. This is followed by descriptions of the different types of metabolizing enzymes. The book is then divided into two sections according to therapeutic class of drug. One section is on drugs as substrates for metabolizing enzymes and the other is drugs as inhibitors of metabolizing enzymes. Organizing the drugs according to classes makes it helpful for pharmacists or clinicians to look for a drug which is least likely to produce a drug interaction in a particular patient. This division ultimately proves confusing and there appears to be overlap. Still, there is an excellent cross referencing section at the end which makes it easy to find specific drug-drug interactions.
Assessment: The editors have presented an excellent compendium on what is currently known about metabolic drug interactions. This book is particularly helpful in assessing the significance of drug-metabolism, the types of drug-drug interactions that can occur, and the pharmacokinetic factors that can affect drug interactions.