Metabolic Encephalopathy / Edition 1

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Metabolic Encephalopathy is meant to combine and correlate animal and human studies. In many cases, alterations in the neurochemistry of humans and experimental animal models are similar. It is hoped that increased awareness of the importance of early diagnosis and treatment of these disorders may result in a lowering of the incidence of structural changes and morbidity. These metabolic encephalopathies hold a special fascination for both basic scientists and clinical investigators because they are accessible, treatable, and there exist good animal models for further study. Therefore, this book assembles both basic and clinical neuroscience issues in the treatment of specific metabolic encephalopathies such as uremia, Wernicke's disease, epilepsy, stroke, hepatic encephalopathy, pediatric encephalopathies, inborn errors of metabolism, toxins such as lead, depression, cerebral infections, kernicterus, Wilson disease, HIV encephalopathy, and many others.
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Editorial Reviews

From the Publisher

From the reviews:

"This book summarises a wealth of information on several neurological disorders from animal models to human conditions … . This approach provides the book with a useful role for continuous education of general neurologists and for introducing neurological diseases to trainees in a modern way. … this book helps to increase awareness of the importance of early diagnosis and treatment of these disorders, which can reduce the incidence of structural brain changes and morbidity." (Antonio Federico, The Lancet Neurology, Vol. 8, August, 2009)

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Product Details

  • ISBN-13: 9780387791098
  • Publisher: Springer New York
  • Publication date: 8/27/2008
  • Edition description: 2009
  • Edition number: 1
  • Pages: 601
  • Product dimensions: 6.40 (w) x 9.30 (h) x 1.30 (d)

Table of Contents

Preface. David.W. McCandless.- 1. Functional Anatomy of the Brain. John M. DeSesso.- 2. Brain Metabolic Adaptations to Hypoxia. Michelle A. Puchowicz, Smruta S. Koppaka, and Joseph C. LaManna.- 3. Hypoglycemic Brain Damage.- Roland N. Auer.- 4. Experimental Ischemia: Summary of Metabolic Encephalopathy. W. David Lust, Jennifer Zechel, and Svetlana Pundik.- 5. Stroke—Clinical Features. Svetlana Pundik, and Jose I. Suarez.- 6. The Role of Animal Models in the Study of Epileptogenesis. Kate Chandler, Pi-Shan Chang, and Matthew Walker.- 7. Seizure-Induced Neuronal Plasticity and Metabolic Effects. Monisha Goyal.- 8. Metabolic Encephalopathies in Children. Joseph DiCarlo.- 9. Pathophysiology of Hepatic Encephalopathy: Studies in Animal Models. Roger F. Butterworth.- 10. Hepatic Encephalopathy. Karin Weissenborn.- 11. Uremic and Dialysis Encephalopathies. Allen I. Arieff.- 12. Thiamine Deficiency: A Model of Metabolic Encephalopathy and of Selective Neuronal Vulnerability. Saravanan Karuppagounder and Gary E. Gibson.- 13. Alcohol, Apoptosis, and Oxidative Stress. George I Henderson, Jennifer Stewart, and Steven Schenker.- 14. Wernicke’s Encephalopathy. Maryam R. Kashi, George I Henderson, and Steven Schenker.- 15. The Genetics of Myelination in Metabolic Brain Disease: The Leukodystrophies. John W. Rumsey.- 16. Bilirubin Encephalopathy. Jeffrey W. McCandless and David W McCandless.- 17. Infectious And Inflammatory Metabolic Encephalopathies: Concepts in Pathogenesis. Kottil Rammohan.- 18. Major Depression and Metabolic Encephalopathy: Syndromes More Alike Than Not? Brian H. Harvey.- 19. Attention-deficit/hyperactivity Disorder as a Metabolic Encephalopathy. Vivienne Ann Russell.- 20. Brain Damage in Phenylalanine, Homocysteine, and Galactose Metabolic Disorders. Kleopatra H.Schulpis and Stylianos Tsakiris.- 21. Wilson Disease. Peter Ferenci.- 22. Metabolic Abnormalities in Alzheimer Disease. Florian M. Gebhardt and Peter R Dodd.- 23. Prions and the Transmissible Spongiform Encephalopathies. Richard C. Wiggins.- 24. Lead Encephalopathy. Ivan J. Boyer.- Index.

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