Metabolic Regulation in Mammals [NOOK Book]

Overview

Metabolic Regulation in Mammals presents the basic principles of metabolic control, based on investigations conducted during the past twenty years. It explains the impact of recent advances in cell biology, molecular biology and genetics on the field. Beginning with the basic concepts, this text covers all angles of metabolic regulation, including blood caloric homeostasis, cardiac and skeletal muscle, adipose tissue, and liver metabolism. Review questions, summary sections and worked examples help break down the...

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Metabolic Regulation in Mammals

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Overview

Metabolic Regulation in Mammals presents the basic principles of metabolic control, based on investigations conducted during the past twenty years. It explains the impact of recent advances in cell biology, molecular biology and genetics on the field. Beginning with the basic concepts, this text covers all angles of metabolic regulation, including blood caloric homeostasis, cardiac and skeletal muscle, adipose tissue, and liver metabolism. Review questions, summary sections and worked examples help break down the complexity of the subject and allow the reader to review the principles and concepts presented. Details of metabolic pathways are provided for each body system, with accompanying charts to provide the reader with an overall perspective. This text is ideal for undergraduates across a range of biological and health science disciplines, particularly those taking one or two semester courses in metabolic regulation.

"...aims to present the basic principles of metabolic control developed during the past 20 years & explains the recent advances in cell biology, molecular biology & genetics on this field."

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Product Details

  • ISBN-13: 9780203381038
  • Publisher: Taylor & Francis, Inc.
  • Publication date: 11/22/2001
  • Sold by: Barnes & Noble
  • Format: eBook
  • Pages: 240
  • File size: 8 MB

Meet the Author

Professors Gibson and Harris both lecture at the department of Biochemistry and Molecular Biology, Indiana University, Indianapolis, USA.

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Table of Contents

Biographical sketches
Series editor's preface
Preface
Acknowledgments
Introduction 1
1.1 Evolution of synthetic systems 1
1.2 Hierarchies of biomolecules 6
1.3 Membranes of animal cells 13
1.4 Coupled reactions 14
1.5 Enzyme catalysis 15
1.6 Steady-state turnover 17
1.7 The animal organism 18
Enzyme-catalyzed Reactions 23
2.1 Energetics of chemical reactions 23
2.2 Coenzymes 26
2.3 Multienzyme pathways 30
2.4 Catalysis 32
2.5 Kinetics of enzyme-catalyzed reactions 33
Regulatory Mechanisms 41
3.1 Introduction: levels of control 41
3.2 Cell-to-cell communication elicits specialized cellular responses 42
3.3 The specific signal-response connection 46
3.4 Intracellular signal transduction from receptors to target proteins 46
3.5 Signal-response to beta-adrenergic hormones 48
3.6 Glucagon signal pathway 54
3.7 Insulin signal pathway 57
3.8 Functional target proteins 63
3.9 Additional signal transduction systems 73
4 Nutrient Homeostasis 81
4.1 Introduction 81
4.2 Digestion and distribution of exogenous nutrients 83
4.3 Flows of nutrients among tissues in well-fed and starvation states 87
4.4 Quality of nutrients 93
4.5 Metabolic demand 93
4.6 Circadian clocks 94
5 The Red Blood Cell 98
5.1 Cell structure 98
5.2 Dissipative systems 100
5.3 Cellular homeostasis 102
5.4 Glycolysis 103
5.5 Homeostasis of electrolytes 108
5.6 Replacement synthesis of cellular components 110
5.7 Maintenance of reductive status 112
5.8 Support of cellular homeostasis by the organism 113
5.9 Specialized function of the RBC 115
6 Muscle Metabolism 123
6.1 Introduction 123
6.2 Glycolysis, glycogenolysis and glycogenesis 124
6.3 Oxidative decarboxylation of pyruvate 128
6.4 The citric acid cycle 131
6.5 Electron transport 134
6.6 Oxidative phosphorylation 135
6.7 Fatty acid oxidation 138
6.8 Regulation of fuel selection in various metabolic states 140
6.9 Mitochondria and oxygen toxicity 152
7 Adipose Tissue Metabolism 156
7.1 Introduction 156
7.2 Synthesis of TG and fatty acids 161
7.3 Control of metabolic flux 164
7.4 Coordinate induction and repression of lipogenic enzymes 165
7.5 Reversible phosphorylation 167
7.6 Allosteric feedback 170
7.7 Hormone-sensitive lipase 170
7.8 Negative feedback by leptin: lipostatic control 170
8 Liver Metabolism 177
8.1 Introduction 177
8.2 Regulation of liver metabolic processes in the well-fed state 180
8.3 Regulation of liver metabolic processes in the starved state 189
8.4 Urea synthesis and its control 196
8.5 Cholesterol metabolism and its control 199
Answers to questions 213
Index 221
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