The Metabolic Syndrome: The Road Map from Inflammation to Cardiovascular Disease, ICS 1303: Proceedings of the 9th European Symposium on Metabolism, held in Padua, Italy, between 12 and 14 October 2006

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This collection of papers represents an edited version of the Proceedings of the 9th European Symposium on Metabolism which was held at the University of Padua (Italy) from October 12-14, 2006. As did the Symposium itself, this work unites under a single cover topics dealing with four important metabolic alterations: diabetes, obesity, hyperlipidemia and hypertension. Of vital interest to the scientific community because of their cost in human life and medical expenditure, the latest edition of this Symposium received much attention from investigators in these fields. The 2006 edition focusses on the most recent epidemiologic findings on the role of oxidative stress and of endothelial dysfunction on the development of atherosclerosis. Other topics of particular interest are: abdominal obesity, pro-inflammatory adipokines and atherogenesis; the metabolic syndrome and cardiovascular global risk; coronary and cerebrovascuclar disease in diabetes and in the metabolic syndrome. Finally, the management, prevention and treatment of the metabolic syndrome and its cardiovascular complications are examined in the light of several recent clinical trials in these fields. This volume will certainly be of interest to all those practitioners and specialists who are looking for a broad, though specific overview on several aspects of insulin resistance as a possible pathogenetic mechanism and a guide to preventing and treating the metabolic syndrome and its cardiovascular complications in their patients.
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Product Details

  • ISBN-13: 9780444528896
  • Publisher: Elsevier Health Sciences
  • Publication date: 10/10/2007
  • Series: International Congress Series, #1303
  • Pages: 188
  • Product dimensions: 6.60 (w) x 9.50 (h) x 0.60 (d)

Table of Contents

Acknowledgements and Introduction     v
Preface     vii
Is the metabolic syndrome still alive?     1
The metabolic syndrome: Is it still alive?   E. Bonora     3
Global management of high risk patients: Integrated primary cardiovascular prevention in diabetics   A.A. Conti   M. Minelli   G.F. Gensini     10
The metabolic syndrome: a widespread inflammatory disease     21
Inflammation and macrophage infiltration in adipose tissue: A link between diabetes and atherosclerosis   R. Menghini   R. Lauro   M. Federici     23
Adipokines, systemic inflammation and inflamed adipose tissue in obesity and insulin resistance   U. Smith   C.X. Andersson   B. Gustafson   A. Hammarstedt   P. Isakson   E. Wallerstedt     31
Oxidative stress, inflammation and atherosclerotic plaque development   F. Cipollone   M.L. Fazia   A. Mezzetti     35
Insulin signaling in hypertension   B. Trimarco   S. Crispo   C. Morisco     41
The metabolic syndrome: the significance of microvascular and macrovascular diseases     49
Diabetic nephropathy: An update on renal structure   P. Fioretto   M. Bruseghin   I. Barzon   M. Arboit   M. Dalla Vestra     51
Erectile dysfunction as a predictor of cardiovascular risk   P. Montorsi     60
Cerebrovascular disease in type 2 diabetes   M. Laakso   J. Kuusisto     65
Coronary heart disease in diabetes   A. Avogaro   G. Fadini   S. Vigili de Kreutzenberg   A. Tiengo     70
Atherothrombotic disease and the metabolic syndrome   G. Davi   F. Santilli     74
Dyslipidemia in the metabolic syndrome: genes and environment     83
Premature coronary artery disease and apolipoprotein B and apolipoprotein A-I   A.F. Ayyobi   A. Zambon   J.D. Brunzell     85
The role of genetic predisposition and biomarkers in atherosclerosis   G. Assmann   H. Schulte   U. Seedorf     95
The anti-atherogenic properties of HDL particles   G. Zuliani   G.B. Vigna   R. Fellin     103
The metabolic syndrome: the treatment of complex disease(s)     111
Global cardiovascular risk: The benefits of a precocious, aggressive treatment strategy   C. Bilato   S. Iliceto     113
Inhibition of synthesis and absorption of cholesterol: A new option in managing hypercholesterolemia   L. Grigore   G.D. Norata   A.L. Catapano     121
LIFE (losartan intervention for endpoint reduction in hypertension) study and its substudies   C. Borghi   S. Ertek     129
When and how to restore [beta]-cell function?   F. Pancani   R. Lupi   R. Miccoli   P. Marchetti   S. Del Prato     138
The blockade of the endocannabinoid CB1 receptors and its influence on cardiometabolic risk: Lesson from Rimonabant In Obesity (RIO) trials   R. Vettor   M. Rossato   F. Fallo   C. Pagano     146
Efficacy and safety of pioglitazone: The proactive study   P. Brunetti     155
Lifestyle and outcome among patients with type 2 diabetes   G. Hu   J. Tuomilehto     160
Author index     173
Keyword index     175
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