A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides
systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews
the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while ...
See more details below
Metabolism of Drugs and Other Xenobiotics

Available on NOOK devices and apps  
  • NOOK Devices
  • Samsung Galaxy Tab 4 NOOK 7.0
  • Samsung Galaxy Tab 4 NOOK 10.1
  • NOOK HD Tablet
  • NOOK HD+ Tablet
  • NOOK eReaders
  • NOOK Color
  • NOOK Tablet
  • Tablet/Phone
  • NOOK for Windows 8 Tablet
  • NOOK for iOS
  • NOOK for Android
  • NOOK Kids for iPad
  • PC/Mac
  • NOOK for Windows 8
  • NOOK for PC
  • NOOK for Mac
  • NOOK for Web

Want a NOOK? Explore Now

NOOK Book (eBook)
BN.com price
(Save 42%)$240.00 List Price
Note: This NOOK Book can be purchased in bulk. Please email us for more information.


A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides
systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews
the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three
main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from
five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse

including nicotine, alcohol and "designer" drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular
Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.
Read More Show Less

Editorial Reviews

Doody's Review Service
Reviewer: Feng Li, PhD (University of Kansas Medical Center)
Description: This comprehensive handbook discusses the metabolism of numerous xenobiotic chemicals such as therapeutic drugs, natural products, and food components and supplements, as well as environmental pollutants and insecticides. The authors are worldwide experts in the field from various research institutes and universities around the world; some are accomplished clinical pharmacologists.
Purpose: The goal is to provide readers with comprehensive information on xenobiotic metabolism by devoting individual chapters to substances in a given chemical class. Thus, it provides a systematic discussion on important metabolic pathways of most major classes of xenobiotics in the human body.
Audience: This book is targeted at medical professionals, toxicologists, and medicinal chemists working both in academic and industrial fields.
Features: The first part of the book covers drug metabolizing enzymes (phase I and phase II) and transporting systems in detail. This is followed by a discussion of the regulation of human CPYP450 enzymes as it relates to advances in pharmacogenomics. The second part features the metabolism of marketed drugs and is organized by drug classes, including discussions on nicotine, alcohol, and illegal abused drugs. Parts three and four address the metabolism of natural products and unnatural xenobiotics, respectively.
Assessment: Compared to the other books in this area, this one goes beyond the discussion of the metabolism of therapeutic drugs to cover many other xenobiotic chemicals including natural products from herbs and food supplements, abused drugs, industrial chemicals and environmental pollutants. Moreover, information on the metabolism of many of the xenobiotic chemicals covered in this book is rarely found in previously available books on this topic. For example, this book covers more than 300 substances found in medications used for the treatment of the central nervous system, cardiovascular system, cancer, infectious diseases, and pain. This book also illustrates the importance of general principles of drug metabolism using well-documented case studies, which renders it very valuable for those teaching courses on drug metabolism and molecular toxicology.
From the Publisher
“Overall therefore, a book which can be read in its own right for the first half and then a valuable source of reference for the second half.  A useful tome to have on the bookshelf for anyone in the field.”  (British Toxicology Society, 1 July 2013)
Read More Show Less

Product Details

  • ISBN-13: 9783527646326
  • Publisher: Wiley
  • Publication date: 2/23/2012
  • Sold by: Barnes & Noble
  • Format: eBook
  • Edition number: 1
  • Pages: 753
  • File size: 9 MB

Meet the Author

Pavel Anzenbacher heads the Department of Pharmacology at Palacky University, Olomouc (Czech Republic) and is vicepresident of the Czech Society of Clinical and Experimental Pharmacology and Toxicology. Having obtained his academic degrees from Charles University, Prague and from the Academy of Sciences of the Czech Republic he joined the Faculty of Medicine at Palacky University. His scientific contacts and stays have included e.g. the Princeton University, Vanderbilt University, Nashville, University of Connecticut, INSERM Montpellier, University of Lubeck, Technical University Berlin and Jagellonian University Cracow. Professor Anzenbacher has authored over 150 original scientific publications and has, among other honours, received the Fogarty Award of the USPHS.

Ulrich M. Zanger is deputy head of the Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart (Germany). A chemist by training, he began to work on drug metabolism at the Biocenter of the University of Basel, Switzerland, where he obtained a PhD
degree in biochemistry. He undertook postdoctoral studies at the Southwestern Medical Center at Dallas, Texas, before returning to Basel and later moving to Stuttgart. His major research interests are in human drug metabolizing cytochromes P450 and in basic and clinical aspects
of pharmacogenetics/genomics. Professor Zanger has authored more than 130 scientific articles and is lecturing in pharmacology and toxicology at the University of Tübingen.
Read More Show Less

Table of Contents


PART ONE: Biochemistry and Molecular Genetics of Drug Metabolism

Introduction: Fate of a Drug in the Human Body
Classification Systems of Drug-Metabolizing Enzymes According to Different Criteria
Overview of the Most Important Drug-Metabolizing Enzyme

Introduction and Historical Perspective
Nomenclature and Gene Organization
Protein Structure
Catalytic Mechanisms
What Determines P450 Catalytic Selectivity?
Oxidative Stress and P450s
Relevance in Drug Metabolism and Clinical Medicine

A Simple Phenotype: Unconjugated Nonhemolytic
Hyperbilirubinemia and Glucuronidation
Organization of UGTs and the UGT1A Gene Locus
UGT1A Gene Nomenclature
Human UGT1A Gene Locus and Sequence Variability
Glucuronidation of Bilirubin
UGT1A1 Gene
Is There an Advantage or Risk Associated with UGT1A1 Variability?
UGT1A1 Gene and Pharmacogenetic Protection
UGT1A1 Gene and Pharmacogenetic Risks
UGT1A1 Variability and Cancer Risk
UGT1A3 Gene
UGT1A7 Gene
Transcriptional Regulation of UGT1A Genes
Aryl Hydrocarbon Receptor/Aryl Hydrocarbon Receptor Nuclear Translocator Regulation of UGT1A Genes
Regulation by Hepatic Nuclear Factors
Regulation by the Farnesoid X Receptor
Regulation by Nuclear Factor Erythroid 2-Related Factor 2
Regulation by Splice Variants
Animal Models to Study UGT1A Genes

PAPS Synthesis
SULT Enzyme Family
Assays for SULT Activity
Structure and Function of SULT
SULT Pharmacogenetics
Bioactivation and the Role of SULTs in Toxicology
Conclusions and Future Perspectives

Introduction and History
Nomenclature, Structure, and Function
Regulation, Induction, and Inhibition
Gene Polymorphism of GSTs

Epoxide Hydrolases
Other Hydrolases

Classification of Drug Transporters and Transport Mechanisms
Drug Transporters of the SLC Superfamily
ABC Drug Transporters
Drug Transporters and Disease
Drug Transporters and Pharmacokinetics
Role of Drug Transporters in Chemotherapy Resistance
Pharmacogenomics of Drug Transporters: Implications for Clinical Drug Response

Factors Affecting Drug-Metabolizing Cytochromes P450
Transcriptional Regulation of CYP
Regulation of Drug-Metabolizing CYPs

Pharmacogenetic Polymorphisms
Polygenic and Multifactorial Aspects of Drug Metabolism Phenotype
Genomics Technologies and Approaches

PART TWO: Metabolism of Drugs

Historical Aspects
Diversity of Drug Metabolic Pathways
Influence of Drug Metabolism on Pharmacological Activity
Extrahepatic Drug Metabolism
Factors Affecting Drug Metabolism Activity

Tranquillizers and Hypnotic Agents
Anticonvulsants and Mood Stabilizers
Agents for Dementia and Cognitive Enhancers
Antimigraine Drugs
Other Drugs

RAAS as a Target for Angiotensin-Converting Enzyme Inhibitors and AT1 Receptor Blockers
Adrenergic Receptor Agonists
Adrenergic Receptor Antagonists
Cholesterol-Lowering Drugs

Alkylating Drugs
Platinum-Containing Agents
Endocrine Therapy
Histone Deacetylase Inhibitor (Vorinostat)
Tyrosine Kinase Inhibitors
Proteasome Inhibitor (Bortezomib)

Pharmacokinetics/Pharmacodynamics of the Main Families of Antimicrobial Agents

Acute Pain
Chronic Pain


Classic Drugs of Abuse
Designer Drugs of Abuse

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)