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Doody's Review ServiceReviewer: Feng Li, PhD (University of Kansas Medical Center)
Description: This comprehensive handbook discusses the metabolism of numerous xenobiotic chemicals such as therapeutic drugs, natural products, and food components and supplements, as well as environmental pollutants and insecticides. The authors are worldwide experts in the field from various research institutes and universities around the world; some are accomplished clinical pharmacologists.
Purpose: The goal is to provide readers with comprehensive information on xenobiotic metabolism by devoting individual chapters to substances in a given chemical class. Thus, it provides a systematic discussion on important metabolic pathways of most major classes of xenobiotics in the human body.
Audience: This book is targeted at medical professionals, toxicologists, and medicinal chemists working both in academic and industrial fields.
Features: The first part of the book covers drug metabolizing enzymes (phase I and phase II) and transporting systems in detail. This is followed by a discussion of the regulation of human CPYP450 enzymes as it relates to advances in pharmacogenomics. The second part features the metabolism of marketed drugs and is organized by drug classes, including discussions on nicotine, alcohol, and illegal abused drugs. Parts three and four address the metabolism of natural products and unnatural xenobiotics, respectively.
Assessment: Compared to the other books in this area, this one goes beyond the discussion of the metabolism of therapeutic drugs to cover many other xenobiotic chemicals including natural products from herbs and food supplements, abused drugs, industrial chemicals and environmental pollutants. Moreover, information on the metabolism of many of the xenobiotic chemicals covered in this book is rarely found in previously available books on this topic. For example, this book covers more than 300 substances found in medications used for the treatment of the central nervous system, cardiovascular system, cancer, infectious diseases, and pain. This book also illustrates the importance of general principles of drug metabolism using well-documented case studies, which renders it very valuable for those teaching courses on drug metabolism and molecular toxicology.