Metabolism of Drugs and Other Xenobiotics

Metabolism of Drugs and Other Xenobiotics

by Pavel Anzenbacher
     
 

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A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews the main enzyme systems involved in biotransformation and how they are orchestrated in the body,… See more details below

Overview

A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse including nicotine, alcohol and "designer" drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular toxicology.
Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.

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Editorial Reviews

Doody's Review Service
Reviewer: Feng Li, PhD (University of Kansas Medical Center)
Description: This comprehensive handbook discusses the metabolism of numerous xenobiotic chemicals such as therapeutic drugs, natural products, and food components and supplements, as well as environmental pollutants and insecticides. The authors are worldwide experts in the field from various research institutes and universities around the world; some are accomplished clinical pharmacologists.
Purpose: The goal is to provide readers with comprehensive information on xenobiotic metabolism by devoting individual chapters to substances in a given chemical class. Thus, it provides a systematic discussion on important metabolic pathways of most major classes of xenobiotics in the human body.
Audience: This book is targeted at medical professionals, toxicologists, and medicinal chemists working both in academic and industrial fields.
Features: The first part of the book covers drug metabolizing enzymes (phase I and phase II) and transporting systems in detail. This is followed by a discussion of the regulation of human CPYP450 enzymes as it relates to advances in pharmacogenomics. The second part features the metabolism of marketed drugs and is organized by drug classes, including discussions on nicotine, alcohol, and illegal abused drugs. Parts three and four address the metabolism of natural products and unnatural xenobiotics, respectively.
Assessment: Compared to the other books in this area, this one goes beyond the discussion of the metabolism of therapeutic drugs to cover many other xenobiotic chemicals including natural products from herbs and food supplements, abused drugs, industrial chemicals and environmental pollutants. Moreover, information on the metabolism of many of the xenobiotic chemicals covered in this book is rarely found in previously available books on this topic. For example, this book covers more than 300 substances found in medications used for the treatment of the central nervous system, cardiovascular system, cancer, infectious diseases, and pain. This book also illustrates the importance of general principles of drug metabolism using well-documented case studies, which renders it very valuable for those teaching courses on drug metabolism and molecular toxicology.
From the Publisher
“Overall therefore, a book which can be read in its own right for the first half and then a valuable source of reference for the second half.  A useful tome to have on the bookshelf for anyone in the field.”  (British Toxicology Society, 1 July 2013)

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Product Details

ISBN-13:
9783527646326
Publisher:
Wiley
Publication date:
02/23/2012
Sold by:
Barnes & Noble
Format:
NOOK Book
Pages:
753
File size:
9 MB

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