Metabolomics, Metabonomics and Metabolite Profiling

Overview

The completion of gene sequencing has resulted in an intensified investigation of the proteome and metabolome. Metabolite profiling methods used for disease diagnosis have been expanded with the advent of new technology and are being applied extensively in the quest for the discovery of new markers for diseases. In this comprehensive resource, the Editor draws together experts from the field and provides an insightful introduction into the technology and methodology. Metabolomics, Metabonomics And Metabolite ...

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Overview

The completion of gene sequencing has resulted in an intensified investigation of the proteome and metabolome. Metabolite profiling methods used for disease diagnosis have been expanded with the advent of new technology and are being applied extensively in the quest for the discovery of new markers for diseases. In this comprehensive resource, the Editor draws together experts from the field and provides an insightful introduction into the technology and methodology. Metabolomics, Metabonomics And Metabolite Profiling covers a broad range of topics including:
• Mass spectrometry and NMR in metabolite profiling
• Current applications of metabolite profiling for disease diagnosis
• Studies of specific metabolite classes
• Plant metabolites
• Metabolite data mining
• Global systems biology This book is a must have, up-to-date, reference which will appeal to academics, students, technicians and professionals working in, or joining this field.

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Editorial Reviews

Chemistry in Australia
" The strong point of this book is the generally balanced and integrated presentations between the biological meaning or function of the metabolites and their physical analysis."" This book will be of interest and valuable reading to chemical scientists as it illustrates the mutual relevance and significance of analytical techniques to the life sciences."
From the Publisher
"is a collection of essays on the techniques used in metabolomics, metabonomics and metabolite profiling..." "valuable to those at the interface: biologists who want to apply what are traditionally chemists tools and techniques, and chemists who want to know what it is that excites the biologists."
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Product Details

  • ISBN-13: 9780854042999
  • Publisher: Royal Society of Chemistry, The
  • Publication date: 10/28/2007
  • Series: RSC Biomolecular Sciences Series , #9
  • Pages: 336
  • Product dimensions: 6.40 (w) x 9.30 (h) x 1.00 (d)

Meet the Author

Robert C Murphy graduated from Massachusetts Institute of Technology with a PhD in chemistry and he is currently a University Distinguished Professor at the University of Colorado. He has worked in the area of mass spectrometry and eicosanoid biochemistry for approximately 40 years with much of his research activities centered on the use of mass spectrometry to studies of arachidonic acid biochemistry and formation of the biologically active leukotriene mediators. His interests also include the structural characterizaton of bioactive lipid products derived from the reaction of reactive oxygen species with cellular lipids. Over 400 peer-reviewed papers in scientific journals and several books concerning mass spectrometry of lipids have been authored by him.
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Table of Contents

1. Mass Spectrometry for Metabolite Identification; 2. 1D and 2D NMR Spectroscopy: from Metabolic Fingerprinting to Profiling; 3. Steroids, Sterols and the Nervous System; 4. Phospholipid Profiling; 5. New Developments in Multi-dimensional Mass Spectrometry-Based Shotgun Lipidomics; 6. Neutral Lipidomics and Mass Spectrometry; 7. Bioinformatics of Lipids; 8. Mass Spectrometry in Glycobiology, João Rodrigues; 9. Matrix Assisted Laser Desorption Ionisation Mass Spectrometric Imaging - Principles and Applications; 10. Plant Metabolomics; 11. Data Mining for Metabolomics; 12. Metabonomics and Global Systems Biology;

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