Metal Ions in Gene Regulation

by Simon Silver (Editor), William Walden (Editor)

Overview

This is the first volume on the role of metal ions in regulating genes to focus not only on toxicity effects of metals but also on the role of metal ions in normal metabolisms, in both prokaryotes and in eukaryotes. This book is a comprehensive treatment of the role of metal ions in gene regulation, and it will be of great utility for those doing basic biological and biomedical research.

Product Details

ISBN-13:	9780412053313
Publisher:	Springer US
Publication date:	12/31/1997
Series:	Chapman & Hall Microbiology Series
Edition description:	1998
Pages:	473
Product dimensions:	6.10(w) x 9.25(h) x 0.04(d)
Age Range:	18 Years

Table of Contents

1. Overview of Cellular Inorganic Metabolism and the Need for Gene Regulation.- I: Bacterial Metal Metabolism.- 2. Control of Bacterial Iron Transport by Regulatory Proteins.- 3. Metal Cation Regulation in Gram-Positive Bacteria.- 4. Two-Component Systems in the Regulation of Heavy Metal Resistance.- 5. Phosphate Signaling and the Control of Gene Expression in Escherichia coli.- II: Animal Metal Metabolism.- 6. Translational Regulation of Bioiron.- 7. The Iron Responsive Element (IRE), the Iron Regulatory Protein (IRP), and Cytosolic Aconitase: Posttranscriptional Regulation of Mammalian Iron Metabolism.- 8. Mechanisms for Induction and Rerepression of Ferritin Synthesis.- 9. Metallothionein Gene Regulation in Mouse Cells.- 10. Menkes’ and Wilson’s Diseases: Genetic Disorders of Copper Transport.- III: Lower Eukaryotes and Plants.- 11. Metal Ion Stress in Yeast.- 12. Yeast Metallothionein Gene Regulation.- 13. The Molecular Biology of Iron and Zinc Uptake in Saccharomyces cerevisiae.- 14. Metallothionein Gene Regulation in Cyanobacteria.- 15. Metallothionein-like Genes and Phyhelatins in Higher Plants.- 16. Regulation of Ferritin Synthesis and Degradation in Plants.- 17. Reciprocal, Copper-Responsive Accumulation of Plasyanin and Cyhrome c6 in Algae and Cyanobacteria: A Model for Metalloregulation of Metalloprotein Synthesis.

Editorial Reviews

Addressing the subject areas of bacterial systems, animal metal metabolism, and lower eukaryotes and higher plants, 17 papers cover such topics as the role of Fur repressors, the range of gene regulators of cation metabolism in Gram-positive bacteria, metal- regulating examples of bacterial two-component regulatory systems, metal ion regulated gene expression in animals, iron regulation of animal genes, metallothionein regulation of the prokaryotic cyanobacteria, and the regulation of metal cation stress in yeast. Annotation c. by Book News, Inc., Portland, Or.

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