Metallopharmaceuticals I: DNA Interactions / Edition 1

Metallopharmaceuticals I: DNA Interactions / Edition 1

by Michael J. Clarke
     
 

ISBN-10: 3540648895

ISBN-13: 9783540648895

Pub. Date: 06/22/1999

Publisher: Springer Berlin Heidelberg

Inorganic compounds offer much scope for the design of novel and therapeutic agents. The widespread use of paramagnetic metal complexes as effective contrast agents for magnetic resonsance imaging (e.g. Gd) demonstrates that the toxicity of metals can be finely controlled via the approriate choice of ligands. The successful targeting of radioisotopes again depends

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Overview

Inorganic compounds offer much scope for the design of novel and therapeutic agents. The widespread use of paramagnetic metal complexes as effective contrast agents for magnetic resonsance imaging (e.g. Gd) demonstrates that the toxicity of metals can be finely controlled via the approriate choice of ligands. The successful targeting of radioisotopes again depends on ligand design and metal oxidation state. Bismuth and gold complexes have long been used in medicine but only recently have advances been made in understanding the molecular basis of their mechanism of action. New areas with clinical potential include the use of polyoxometallates and fullerenes as antiviral agents and vanadium complexes as insulin mimetics.

Product Details

ISBN-13:
9783540648895
Publisher:
Springer Berlin Heidelberg
Publication date:
06/22/1999
Series:
Topics in Biological Inorganic Chemistry Series, #1
Edition description:
1999
Pages:
200
Product dimensions:
6.14(w) x 9.21(h) x 0.36(d)

Table of Contents

Anticancer Activity of Cisplatin and Related Complexes1
Development of an Orally Active Platinum Anticancer Drug: JM21645
Trans-Platinum Compounds in Cancer Therapy: A Largely Unexplored Strategy for Identifying Novel Antitumor Platinum Drugs73
Chemistry and Biology of Multifunctional DNA Binding Agents99
Role of Metal Ions in Antisense and Antigene Stategies117
Sulfoxide Ruthenium Complexes: Non Toxic Tools for the Selective Treatment of Solid Tumour Metastases143
Non-Platinum Antitumor Compounds171

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