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Doody's Review ServiceReviewer: Melanie M. Brandabur, MD (University of Illinois at Chicago College of Medicine)
Description: The editor has assembled a great deal of information on the involvement of various metals in neuronal oxidative injury as related to neurological disease and treatment.
Purpose: The book includes the writings of many prominent workers from the spectrum of clinical and basic neurosciences. In the first section, the role of various metals (including iron, which is extensively discussed, as well as copper, manganese, zinc, and others) in oxidative processes is discussed. Next, the contributors explore mechanisms by which the brain is protected from these oxidative insults. The final section explores neurological conditions in which these mechanisms may be involved, such as hypoxic-ischemic encephalopathy, Alzheimer's and Parkinson's diseases, and also discusses potential therapeutic applications based upon these models.
Audience: The book is most useful for those involved in related research in basic neurosciences and those seeking to develop new clinical treatment options for patients afflicted with these conditions, since most of these options do not currently have definitive therapies.
Features: Apart from the striking photomicrographs on the cover, the illustrations and other graphics are functional but not out of the ordinary. The references are current and the substantial index is helpful, particularly in a compilation of this type.
Assessment: This is a well-written book that brings together a cohesive subset of related material and presents it in a useful format. This is an especially timely contribution in view of the current, widespread interest in oxidative processes in neurological disease.