Metals and Oxidative Damage in Neurological Disorders / Edition 1

Hardcover (Print)
Buy New
Buy New from BN.com
$199.20
Used and New from Other Sellers
Used and New from Other Sellers
from $36.60
Usually ships in 1-2 business days
(Save 85%)
Other sellers (Hardcover)
  • All (8) from $36.60   
  • New (4) from $136.53   
  • Used (4) from $36.60   

Overview

This volume brings together scientists and clinicians from diverse disciplines for discussions of oxidative injury in the nervous system. Areas of examination include:

• a review of metals and their role in oxidative injury, with special attention paid to iron
• the mechanisms by which the brain protects itself from oxidative harm
• the clinical diseases in which oxidative injury is known to contribute to the pathogenic process
• antioxidant therapeutic strategies in neurological disorders, and
• a proposed common pathway for oxidative injury in the brain.

The book contains black-and-white illustrations.

Read More Show Less

Editorial Reviews

Doody's Review Service
Reviewer: Melanie M. Brandabur, MD (University of Illinois at Chicago College of Medicine)
Description: The editor has assembled a great deal of information on the involvement of various metals in neuronal oxidative injury as related to neurological disease and treatment.
Purpose: The book includes the writings of many prominent workers from the spectrum of clinical and basic neurosciences. In the first section, the role of various metals (including iron, which is extensively discussed, as well as copper, manganese, zinc, and others) in oxidative processes is discussed. Next, the contributors explore mechanisms by which the brain is protected from these oxidative insults. The final section explores neurological conditions in which these mechanisms may be involved, such as hypoxic-ischemic encephalopathy, Alzheimer's and Parkinson's diseases, and also discusses potential therapeutic applications based upon these models.
Audience: The book is most useful for those involved in related research in basic neurosciences and those seeking to develop new clinical treatment options for patients afflicted with these conditions, since most of these options do not currently have definitive therapies.
Features: Apart from the striking photomicrographs on the cover, the illustrations and other graphics are functional but not out of the ordinary. The references are current and the substantial index is helpful, particularly in a compilation of this type.
Assessment: This is a well-written book that brings together a cohesive subset of related material and presents it in a useful format. This is an especially timely contribution in view of the current, widespread interest in oxidative processes in neurological disease.
Melanie M. Brandabur
The editor has assembled a great deal of information on the involvement of various metals in neuronal oxidative injury as related to neurological disease and treatment. The book includes the writings of many prominent workers from the spectrum of clinical and basic neurosciences. In the first section, the role of various metals (including iron, which is extensively discussed, as well as copper, manganese, zinc, and others) in oxidative processes is discussed. Next, the contributors explore mechanisms by which the brain is protected from these oxidative insults. The final section explores neurological conditions in which these mechanisms may be involved, such as hypoxic-ischemic encephalopathy, Alzheimer's and Parkinson's diseases, and also discusses potential therapeutic applications based upon these models. The book is most useful for those involved in related research in basic neurosciences and those seeking to develop new clinical treatment options for patients afflicted with these conditions, since most of these options do not currently have definitive therapies. Apart from the striking photomicrographs on the cover, the illustrations and other graphics are functional but not out of the ordinary. The references are current and the substantial index is helpful, particularly in a compilation of this type. This is a well-written book that brings together a cohesive subset of related material and presents it in a useful format. This is an especially timely contribution in view of the current, widespread interest in oxidative processes in neurological disease.
Booknews
Scientists and clinicians bring a wide range of approaches to research and treatment design relating to oxidative injury in the nervous system. They review metals and their role in generating oxidative injury, particularly iron; detail mechanisms by which the brain attempts to protect itself from oxidative injury; and survey the clinical diseases in which oxidative injury is known to contribute to the pathogenic process. They also propose a common pathway for oxidative injury to the brain, arguing that whatever the mechanism by which the oxidative stress in triggered, eventually a cascade will be initiated that will result in cell death. The model is consistent across diseases and metals. Annotation c. by Book News, Inc., Portland, Or.

4 Stars! from Doody
Read More Show Less

Product Details

  • ISBN-13: 9780306455346
  • Publisher: Springer US
  • Publication date: 9/30/1997
  • Edition description: 1997
  • Edition number: 1
  • Pages: 374
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.94 (d)

Table of Contents

Ch. 1 Iron and Neurotransmitter Function in the Brain
Ch. 2 Evidence for Iron Mismanagement in the Brain in Neurological Disorders
Ch. 3 Magnetic Resonance Imaging of Brain Iron
Ch. 4 Neurochemical Roles of Copper as Antioxidant or Prooxidant
Ch. 5 Manganese Neurotoxicity and Oxidative Damage
Ch. 6 The Role of Zinc in Brain and Nerve Functions
Ch. 7 Delivery of Metals to Brain and the Role of the Blood-Brain Barrier
Ch. 8 Ferritin: Intracellular Regulator of Metal Availability
Ch. 9 Ascorbate: An Antioxidant Neuroprotectant and Extracellular Neuromodulator
Ch. 10 Vitamin E: Neurochemical Aspects and Relevance to Nervous System Disorders
Ch. 11 Nitric Oxide and Oxidative Damage in the CNS
Ch. 12 Iron and Oxidative Stress in Neonatal Hypoxic-Ischemic Brain Injury: Directions for Therapeutic Intervention
Ch. 13 The Role of Oxidative Processes and Metal Ions in Aging and Alzheimer's Disease
Ch. 14 Oxidative Stress with Emphasis on the Role of LAMMA in Parkinson's Disease
Ch. 15 Perspectives on the Mechanisms of Familial Amyotrophic Lateral Sclerosis Caused by Mutations in Superoxide Dismutase 1
Ch. 16 Tardive Dyskinesia and Oxidative Stress
Ch. 17 Antioxidant Therapeutic Strategies in CNS Disorders
Ch. 18 Oxidative Stress-Induced Cell Damage in the CNS: A Proposal for a Final Common Pathway
Appendix Accepted Biomarkers of Oxidative Damage in Tissues
Index
Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)