Metals in Medicine / Edition 2

Hardcover (Print)
Buy New
Buy New from BN.com
$169.29
Used and New from Other Sellers
Used and New from Other Sellers
from $146.47
Usually ships in 1-2 business days
(Save 20%)
Other sellers (Hardcover)
  • All (7) from $146.47   
  • New (6) from $146.47   
  • Used (1) from $169.28   

Overview

Working from basic chemical principles, Metals in Medicine presents a complete and methodical approach to the topic. Introductory chapters discuss important bonding concepts applicable to metallo-drugs and their biological targets, interactions that exist between the agents and substances in the biological milieu, basic pharmacokinetic and pharmacodynamic properties including transport and uptake of drugs by the cells, and methods for measuring efficacy and toxicity of agents. The steps from drug discovery to market place are also briefly outlined and discussed. These chapters lay the groundwork, in order that students can clearly understand how agents work, whatever their subject background.

Following this introduction, chapters focus on individual metallo-drugs and agents for treating and detecting disease, their synthesis, structure and general properties, known mechanism of action and important physical and chemical principles that apply. Topics covered include cisplatin; platinum anticancer drugs; ruthenium, titanium, and gallium for treating cancer; gold compounds for treating arthritis, cancer, and other diseases; vanadium, copper, and zinc in medicine; metal complexes for diagnosing disease; and metals in nanomedicine.

Throughout the book, “Feature Boxes” expand on features of drugs that are not directly related to studying metals in medicine, for example discovery, medical use, specialist assays, and metals in biology. At the end of the chapters there are specifically designed problems/exercises that apply basic kinetic, thermodynamic and chemical principles to practical problem solving in metals in medicine.

Metals in Medicine distils the essence of this important topic for undergraduate and graduate students in chemistry, biochemistry, biology and the related areas of biophysics, pharmacology, and bioengineering, and for researchers in other fields interested in getting a general insight into metals in medicine.

Read More Show Less

Product Details

  • ISBN-13: 9780470681961
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 1/19/2010
  • Edition number: 2
  • Pages: 334
  • Product dimensions: 7.70 (w) x 9.90 (h) x 1.00 (d)

Table of Contents

Feature Boxes.

Preface.

Acknowledgments.

1 Inorganic Chemistry Basics.

1.1 Crystal field theory.

1.2 Molecular orbital theory.

1.3 Absorption spectra of metal complexes.

1.4 Magnetic properties of metal complexes.

1.5 Reactions of metal complexes.

Problems.

References.

Further reading.

2 Metallo-Drugs and Their Action.

2.1 Introduction.

2.2 Proteins as targets for metallo-drugs.

2.3 DNA as a target for metallo-drugs.

2.4 Reaction of metal complexes in the biological milieu.

2.5 Evaluating the pharmacological effects of agents.

2.6 From discovery to the marketplace.

Problems.

References.

Further reading.

3 Cisplatin.

3.1 Physical and chemical properties of cisplatin.

3.2 Formulation, administration and pharmacokinetics.

3.3 Reaction of cisplatin in biological media.

3.4 Uptake, cytotoxicity and resistance.

3.5 Interaction of cisplatin with cellular targets.

Problems.

References.

Further reading.

4 Platinum Anticancer Drugs.

4.1 Carboplatin.

4.2 Oxaliplatin.

4.3 New platinum agents.

Problems.

References.

Further reading.

5 Ruthenium, Titanium and Gallium for Treating Cancer.

5.1 Ruthenium compounds for treating cancer.

5.2 Titanium compounds for treating cancer.

5.3 Gallium for treating cancer.

Problems.

References.

Further reading.

6 Gold Compounds for Treating Arthritis, Cancer and Other Diseases.

6.1 Chemistry of gold in biological media.

6.2 Gold compounds for treating arthritis.

6.3 Gold complexes for treating cancer.

6.4 Gold complexes for treating AIDS and other diseases.

Problems.

References.

Further reading.

7 Vanadium, Copper and Zinc in Medicine.

7.1 Vanadium for treating diabetes.

7.2 Role of copper and other metal ions in Alzheimer’s disease.

7.3 Copper in Wilson’s and Menkes diseases.

7.4 Zinc–bicyclam: a chemokine receptor antagonist.

Problems.

References.

Further reading.

8 Metal Complexes for Diagnosing Disease.

8.1 Technetium in diagnostic nuclear medicine.

8.2 Metal compounds as contrast agents for MRI.

8.3 Radionuclides for palliative care and cancer treatment.

Problems.

References.

Further reading.

9 Nanomedicine.

9.1 Nanoscience for treating disease.

9.2 Nanomedicine in diagnosing disease.

9.3 Potential health risks of nanoparticles.

Problems.

References.

Further reading.

Index.

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)