Methods in Pain Research

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In the past two decades, pain research has become one of the most rapidly growing areas of neuroscience activity. Methods in Pain Research brings together in a single volume a survey of the methods that can be used to study a reaction or 'sensory report' in humans that can only be inferred by indirect means in animal or tissues studies. It presents source material, useful advice, and guidance to specific details as well as examples of current usage.

With each topic presented by one or more of the leading experts in the field, it examines the major modern techniques used in studying pain, including gene linkage, brain imaging methods, the use of transgenic rodent models, painful sensory neuropathy models, and more. The material also covers conventional methods of pain study, such as anatomical and electophysiological techniques. Methods in Pain Research provides up-to-date methodology and a guide to the strategies of experimental design.

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Editorial Reviews

Doody's Review Service
Reviewer: Celso Agner, MD, MS, MSc (Michigan Neurology Partners)
Description: This book succinctly describes methods of research on pain.
Purpose: The characteristic idiosyncrasy of pain and methods of pain research suggests the fast-paced evolution of the field and the need for a compilation of methods used to assess pain in animals while respecting animal protection laws. The author's objective is to address methods of pain research from different angles, particularly considering the protocols developed in anesthesia and neuroscience laboratories across the world. Those objectives are clearly met.
Audience: The main audience includes anesthetists, neurologists, neurosurgeons, and basic neuroscientists involved in research on pain. This book clearly targets its audience and, more particularly in my view, basic scientists involved in animal pain research. Although some chapters are dedicated to the clinical assessment of pain in humans, it is still questionable whether this book will particularly interest clinical researchers.
Features: Thirty authors contribute 14 chapters to this book. In a well-written, almost protocol approach, the authors address different points of pain research, particularly concerning animal models of pain and methods of investigation of neurochemical compounds involved in the processing of pain in the central nervous system. The scope is broad but the text, to-the-point. The author's expertise is expressed in the conciseness of the text, the graphic quality, the illustrations, and the explanations for the procedures. The price is reasonable.
Assessment: This is an important book for neuroscience libraries and laboratories involved in the study of pain. I do not think it reaches clinicians, though, who are often involved in the daily management of patients with chronic pain. A complete understanding of pain is still beyond research, as it requires a combination of research and an understanding of patients and their sorrows.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780849300356
  • Publisher: CRC Press
  • Publication date: 6/22/2001
  • Series: Frontiers in Neuroscience Series
  • Pages: 336
  • Product dimensions: 6.50 (w) x 9.60 (h) x 0.98 (d)

Table of Contents

The Idiosyncratic Problems Associated with Pain Research, Lawrence Kruger
Assessing Nociception in Murine Subjects, Jeffrey S. Mogil, Sonya G. Wilson, and You Wan
Techniques for Mutagenesis of the Murine Opioid System In Vivo, Michael D. Hayward and
Malcolm Low
Animal Models of Pain, Gary Bennett
Methods in Visceral Pain Research, Timothy J. Ness and Gerald F. Gebhart
The Cytokine Challenge: Methods for the Detection of Central Cytokines in Rodent Models of Persistent Pain, Sarah M. Sweitzer, Janice L. Arruda, and Joyce A. DeLeo
Extracellular Sampling Techniques, Igor Spigelman, Neubert Y. Matsuka, and N.T. Maidment
Electrophysiological Recording Techniques in Pain Research, Igor Spigelman, Michael S. Gold, and Alan R. Light
Membrane Properties: Ion Channels, Michael S. Gold
Anatomical Methods in Pain Research, Susan Carlton and A. Todd
Quantitative Morphology in Relation to Long-Term Pain States: Estimates of Neuron Numbers, Richard E. Coggeshall
Functional Brain Imaging in Humans: Methodology and Issues, Karen Davis
Methods for Imaging Human Brain Pathophysiology of Chronic Pain, Vania A. Apkarian, Ogor D. Grachev, Beth R. Krauss, and Nikolaus M. Szeverenyi
Methods for Induction and Assessment of Pain in Humans with Clinical and Pharmacological Examples, Thomas Graven-Nielson, Marta Segerdahl, Peter Svensson, and Lars Arendt-Nielson

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