Methods in Protein Design

Overview

This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers methods in protein design and it has chapters on such topics as protein switch engineering by domain insertion, evolution based design of proteins, and computationally designed proteins.

  • Continues the legacy of this premier serial with quality...
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Methods in Protein Design

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Overview

This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers methods in protein design and it has chapters on such topics as protein switch engineering by domain insertion, evolution based design of proteins, and computationally designed proteins.

  • Continues the legacy of this premier serial with quality chapters authored by leaders in the field
  • Covers methods in protein design
  • Contains chapters with such topics as protein switch engineering by domain insertion, evolution-based design of proteins, and computationally designed proteins
Read More Show Less

Product Details

  • ISBN-13: 9780123942920
  • Publisher: Elsevier Science
  • Publication date: 3/26/2013
  • Pages: 520
  • Product dimensions: 6.20 (w) x 9.00 (h) x 1.00 (d)

Table of Contents

  1. Computational Design of Novel Protein Binders and Experimental Affinity Maturation
  2. Mining Tertiary Structural Motifs for Assessment of Designability
  3. Computational Methods for Controlling Binding Specificity
  4. Flexible Backbone Sampling Methods to Model and Design Protein Alternative Conformations
  5. OSPREY: ProteinDesignwithEnsembles,Flexibility, and ProvableAlgorithms
  6. Scientific Benchmarks for Guiding Macromolecular Energy Function Improvement
  7. Molecular Dynamics Simulations for the Ranking, Evaluation, and Refinement of Computationally Designed Proteins
  8. Multi-State Protein Design Using CLEVER and CLASSY
  9. Using Analyses of Amino Acid Coevolution to Understand Protein Structure and Function
  10. Evolution Based Design of Proteins
  11. Protein Engineering and Stabilization from Sequence Statistics: Variation and Co-Variation Analysis
  12. Enzyme Engineering by Targeted Libraries
  13. Generation of High-Performance Binding Proteins for Peptide Motifs by Affinity Clamping
  14. Engineering Fibronectin-Based Binding Proteins by Yeast Surface Display
  15. Engineering and Analysis of Peptide-Recognition Domain Specificities by Phage Display and Deep Sequencing
  16. Efficient Sampling of SCHEMA Chimera Families to Identify Useful Sequence Elements
  17. Protein Switch Engineering by Domain Insertion
  18. Design of Chimeric Proteins by Combination of Subdomain-Sized Fragments
  19. a-Helix Mimicry with a/ß-Peptides
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