Methods to Assess DNA Damage and Repair: Interspecies Comparisons

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Integrates data obtained from a variety of disciplines to evaluate the current state of knowledge regarding defense mechanisms and applies this information to estimate health risks to humans exposed to substances that alter genetic material. Recognized experts document, to a large extent, which carcinogens can cause injury to human beings and their surroundings, providing guidance for the structured acquisition of key information to reduce cancer risks throughout the ...
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Overview

Integrates data obtained from a variety of disciplines to evaluate the current state of knowledge regarding defense mechanisms and applies this information to estimate health risks to humans exposed to substances that alter genetic material. Recognized experts document, to a large extent, which carcinogens can cause injury to human beings and their surroundings, providing guidance for the structured acquisition of key information to reduce cancer risks throughout the environment.
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Editorial Reviews

Booknews
Summarizes the current knowledge about natural defense and repair systems by which organisms protect themselves against genetic damage from natural and artificial chemical and physical agents, and uses that knowledge to estimate the risk to health of humans exposed to substances that alter genetic material. Deals predominantly with the mechanisms of activation/detoxification of DNA-damaging agents, organotropic and cell-structure effects, the induction and repair of DNA damage, and the molecular and phenotypical analysis of mutation induction. The contributors are from a range of disciplines to avoid a bias toward any particular agent or species. The report was prepared at a March 1990 workshop in Research Triangle Park, North Carolina. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9780471942566
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 8/16/1994
  • Series: SCOPE Series , #55
  • Edition number: 1
  • Pages: 284
  • Product dimensions: 6.14 (w) x 9.29 (h) x 0.87 (d)

Table of Contents

Foreword
Preface
Acknowledgements
Scientific Group on Methodologies for the Safety Evaluation of Chemicals
Participants of the Workshop
Introduction, General Conclusions, and Recommendations 3
Joint Report: DNA Damage 9
Joint Report: DNA Repair and Mutagenesis 19
Joint Report: DNA Repair, Mutagenesis, and Risk Assessment 23
DNA Adducts and Their Consequences 29
Nucleotide Excision-Repair Among Species 57
Interspecies Determinants: Bioactivation and Inactivation of Carcinogens 83
Monitoring Cytogenetic Damage In Vivo 95
In Vivo Somatic Cell Gene Mutations in Humans 117
DNA Repair in Specific Sequences and Genomic Regions 141
Molecular Analysis of Mutations in Endogenous Genes 161
Molecular Analysis of Mutations in Shuttle Vectors and Transgenic Animals 179
Structure-Activity Relationships (SAR): Computerized Systems 201
Structure-Activity Relationships: Experimental Approaches 231
Index 255
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