Methuselah Flies: A Case Study in the Evolution of Aging

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More About This Textbook


Methuselah Flies presents a project on the biology of aging. It describes research on the first organisms to have their lifespan increased, and their aging slowed, by hereditary manipulation. These organisms are fruit flies from the species Drosophila melanogaster, the great workhorse of genetics. Michael Rose and his colleagues have been able to double the lifespan of these insects, and improved their health in numerous respects as well. The study of these flies with postponed aging is one of the best means we have of understanding, and ultimately achieving, the postponement of aging in humans. As such, the carefully presented detail of this book will be of value to research devoted to the understanding and control of aging.
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Product Details

  • ISBN-13: 9789812387417
  • Publisher: World Scientific Publishing Company, Incorporated
  • Publication date: 6/28/2004
  • Pages: 496
  • Product dimensions: 7.58 (w) x 10.08 (h) x 1.09 (d)

Table of Contents

Introduction : why Methuselah flies?
1 The creation of Methuselah flies by laboratory evolution 3
2 Laboratory evolution of postponed senescence in Drosophila melanogaster 10
3 Quantitative genetics of postponed aging in Drosophila melanogaster : I. analysis of outbred populations 17
4 Long-term laboratory evolution of a genetic life-history trade-off in Drosophila melanogaster : I. the role of genotype-by-environment interaction 26
5 Evolutionary patterns among measures of aging 40
6 Increasing stress resistance often postpones aging 53
7 Resistance to environmental stress in Drosophila melanogaster selected for postponed senescence 58
8 Selection on stress resistance increases longevity in Drosophila melanogaster 68
9 Metabolic reserves and evolved stress resistance in Drosophila melanogaster 78
10 Physiological mechanisms of evolved desiccation resistance in Drosophila melanogaster 89
11 Postponed aging and desiccation resistance in Drosophila melanogaster 101
12 Reproduction, nutrition, and aging 117
13 Phenotypic plasticity and selection in Drosophila life-history evolution : 1. nutrition and the cost of reproduction 122
14 Metabolic aspects of the trade-off between fecundity and longevity in Drosophila melanogaster 145
15 Phenotypic plasticity and selection in Drosophila life-history evolution : 2. diet, mates and the cost of reproduction 165
16 Genetics and molecular biology 193
17 The effect of superoxide dismutase alleles on aging in Drosophila 198
18 Two-dimensional protein electrophoretic analysis of postponed aging in Drosophila 205
19 Allozymic differentiation in response to laboratory demographic selection of Drosophila melanogaster 221
20 Increased hsp22 RNA levels in Drosophila lines genetically selected for increased longevity 229
21 Electrophoretic analysis of Methuselah flies from multiple species 237
22 Reverse evolution of aging 251
23 Multiple genetic mechanisms for the evolution of senescence in Drosophila melanogaster 255
24 Desiccation, flight, glycogen, and postponed senescence in Drosophila melanogaster 264
25 Variation in the reversibility of evolution 283
26 Reverse evolution of fitness in Drosophila melanogaster 286
27 Reverse evolution of aging in Drosophila melanogaster 296
28 Relaxed stress selection in Drosophila melanogaster 323
29 Aging, development, and crowding 355
30 Interactions between density-dependent and age-specific selection in Drosophila melanogaster 359
31 The evolution of development in Drosophila melanogaster selected for postponed senescence 370
32 Experimental evolution of accelerated development in Drosophila : 1. development speed and larval survival 390
33 Density-dependent natural selection in Drosophila : correlations between feeding rate, development time and viability 406
34 Experimental evolution of accelerated development in Drosophila : 2. adult fitness and the fast development syndrome 413
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