Mild Cognitive Impairment: Aging to Alzheimer's Disease

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What are the boundary zones between normal aging and Alzheimer's disease (AD)? Are many elderly people whom we regard as normal actually in the early stages of AD? Alzheimer's disease does not develop overnight; the early phases may last for years or even decades. Recently, clinical investigators have identified a transitional condition between normal aging and and very early Alzheimer's disease that they have called mild cognitive impairment, or MCI. This term typically refers to memory impairment beyond what one would expect in individuals of a given age whose other abilities to function in daily life are well preserved. Persons who meet the criteria for mild cognitive impairment have an increased risk of progressing to Alzheimer's disease in the near future. Though many questions about this condition and its underlying neuropathology remain open, full clinical trials are currently underway worldwide aimed at preventing the progression from MCI to Alzheimer's disease. This book addresses the spectrum of issues involved in mild cognitive impairment, and includes chapters on clinical studies, neuropsychology, neuroimaging, neuropathology, biological markers, diagnostic approaches, and treatment. It is intended for clinicians, researchers, and students interested in aging and cognition, among them neurologists, psychiatrists, geriatricians, clinical psychologists, and neuropsychologists.

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Editorial Reviews

From the Publisher
"Mild Cognitive Impairment should be of considerable interest to both community and academic neurologists as well as geriatricians and geriatric psychiatrists. Petersen has assembled a strong set of writers to cover all aspects of the MCI question." -Howard Chertkow, M.D., Canada.

". . . a broad and encompassing resource . . . the chapters are stellar in their readability and informative nature . . . well written, well organized, and well referenced." —JINS

"The chapters in this very interesting book address the range of issues that identify this area of inquiry: clinical studies, cognitive tests, magnetic resonance imaging (MRI), neuropathological changes, biological markers, and clinical evaluation...For those who work with geriatric patients, this is a very interesting volume. As a clinician, I found it very instructive."—American Journal of Psychiatry

"This is a well-written, authoritative, multiauthored book on the emerging concept of minimal cognitive impairment. Not only is it readable, but it reflects current state-of-the-art thinking about this concept that is in transition. Experts on dementia will want to have a copy of this book."—Doody's

". . . an excellent introductory and/or review book for clinicians and researchers . . . a 'must have' book for your library." —The Clinical Neuropsychologist

"...I highly recommend this book for anyone involved in clinical or research activities in AD and MCI. Petersen has put together the most comprehensive review of this topic available. Given the predicted future growth in prevalence of MCI and AD, the topics covered in this book will become increasingly salient..." —Archives of Neurology

"an interesting, thought-provoking, sometimes controversial and eminently readable book...a comprehensive and highly accessible account of current thinking about MCI, which will be useful for clinicians and researchers who are interested in ageing and dementia...a valuable resource."—J.S. Snowden in BRAIN

"...this book offers a useful summary of the relevant research across topics and issues pertaining to the concept of MCI."—Applied Neuropsychology

Doody's Review Service
Reviewer: Daniel B. Hier, MD (University of Illinois at Chicago College of Medicine)
Description: This is an authoritative book that helps define the scope and complexity of the emerging concept of mild cognitive impairment.
Purpose: The term mild cognitive impairment or MCI is now emerging as the preferred term to define cognitive impairment that may be a prodrome to Alzheimer's disease or other dementias. This book collects authoritative reviews about the definition and use of this new terminology.
Audience: This is a key book for investigators involved in research on either early stages of dementia or prodromal states prior to the diagnosis of Alzheimer's disease. Most investigators who study dementia will want to be familiar with the concepts in this concise book.
Features: The editor and his collaborators carefully detail the history, definition, and symptomatology of minimal cognitive impairment. Two chapters examine the neuropsychological test complexities in terms of defining what is MCI and what is not. There are two excellent chapters on pathological changes in Alzheimer's disease and their relation to MCI. Two solid chapters on neuroimaging examine the overlap between MCI and Alzheimer's disease in functional and structural brain imaging. One chapter reviews the lack of biological markers for MCI. The book concludes with two very practical chapters on the office diagnosis and management of MCI.
Assessment: This is a well-written, authoritative, multiauthored book on the emerging concept of minimal cognitive impairment. Not only is it readable, but it reflects current state-of-the-art thinking about this concept that is in transition. Experts on dementia will want to have a copy of this book.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780195123425
  • Publisher: Oxford University Press, USA
  • Publication date: 1/28/2003
  • Pages: 288
  • Product dimensions: 9.40 (w) x 6.30 (h) x 1.00 (d)

Table of Contents

1. Introduction, Ronald C. Petersen
2. Clinical Features, Ronald C. Petersen, John C. Morris
3. Neuropsychiatric Symptoms, Jeffrey L. Cummings
4. Normative Neuropsychology in Aging and Mild Cognitive Impairment, Glenn E. Smith, Robert J. Ivnik
5. Optimizing Cognitive Test Norms for Detecting Mild Cognitive Impairment, Martin Sliwinski, Richard Lipton, Herman Buschke, Christina Wasylyshyn
6. Magnetic Resonance Imaging, Clifford R. Jack, Jr.
7. Functional Imaging, Marilyn S. Albert, Keith A. Johnson
8. Spectrum of Pathology from Normal Function to Mild Cognitive Impairment, Heiko Braak, Eva Braak
9. Role of Entorhinal Cortext and Superior Temporal Sulcus, Bradley T. Hyman, Teresa Gomez-Isla
10. Biological Markers, Neill R. Graff-Radford, Steven G. Younkin
11. Clinical Evaluation, Ronald C. Petersen
12. Treatment of Mild Cognitive Impairment and Prevention of Alzheimer's Disease, David S. Knopman

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