Mims' Pathogenesis of Infectious Disease / Edition 5

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Mims' Pathogenesis of Infectious Disease is the landmark book in the field of infectious disease. The new, revised edition of this work provides a comprehensive, up-to-date description of the mechanisms of microbial infection and the pathogenesis of infectious disease. Presented in a clear, accessible style, it deals in an integrated manner with the spectrum of microorganisms, describing the factors common to all infectious diseases. Molecular biology, pathology, and immunology are brought together to explain the mechanisms for spread, immune response, and recovery.

Key features and of the 5th edition include:
• Microbial gene sequencing
• Up-to-date picture of the global burden of infectious diseases
• Role of bacterial virulence factors in vivo, as contrasted with possibilities based on in vitro evidence
• Latest data on combination vaccines, the promise of edible vaccines
• The spread of antibiotic resistance genes among bacteria
• HIV1 and HIV2; molecular biology, pathogenesis and origin
• Latest data on tuberculosis - the number one infectious disease worldwide
• Recent work on papillomaviruses, herpesviruses, BSE and variant CJD
• Latest data on microbial evasion of immune defences
• Origin and molecular biology of pandemic influenza
• Significance of toxins
• An update on vaccines, prions, immune evasion, microbial ligands and receptors

Audience: Undergraduate and graduate students in microbiology and immunology, medical students, and others new to the field of microbiology and infectious diseases.

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Editorial Reviews

From the Publisher
Praise for the previous editions:
"A splendidly imaginative book which will become a trusty companion for many of us."
- The Lancet
"An excellent book which should be read by teachers, students, and research workers."
- New Scientist
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Product Details

  • ISBN-13: 9780124982659
  • Publisher: Elsevier Science
  • Publication date: 9/28/2000
  • Edition number: 5
  • Pages: 474
  • Product dimensions: 0.99 (w) x 6.69 (h) x 9.61 (d)

Meet the Author

Dr. Ross Fitzgerald is the principle investigator for the Laboratory for Bacterial Evolution and Pathogenesis, Centre for Infectious Diseases based at the College of Medicine and Veterinary Medicine, University of Edinburgh. The laboratory is focused on the use of genomic and molecular tools to examine the evolution and pathogenesis of clinically important species of Staphylococci. Dr. Fitzgerald has published numerous papers in peer-reviewed research journals.

Cedric Mims began as a zoologist, studying under GP Wells and JBS Haldane at University College, London. He then went to the Middlesex Hospital Medical School, London, graduating in 1952. After hospital appointments he spent three years in Uganda studying tropical fevers, and then 16 years in Canberra, Australia, interspersed with two years in the USA. This was followed by a 20-year period in London as Professor of Microbiology at Guy's Hospital Medical School, where his enthusiasm for teaching found its outlet. His entire career has focused on infectious diseases and immunology, and he has produced five books and more than a hundred scientific papers on these subjects. He has four children and nine grandchildren and lives in the Sussex countryside.

Professor Tony Nash is Head of Department of Veterinary Pathology and Group Leader and Director of the Centre for Infectious Diseases at the Roslin Institute, University of Edinburgh, UK. The Roslin Institute is the foremost research institute for livestock genetics and genomics in the UK and a major player in international research in this area. Dr. Nash has published over 100 papers in peer reviewed journals, is a Fellow of the Royal Society of Edinburgh and of the United Kingdom Academy of Medical Sciences, and is a member of the Society for General Microbiology, Council of the Society for General Microbiology, British Society of Immunology, and of the Biotechnology and Biological Sciences Research Council.

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Table of Contents

Preface to the Fourth Edition
Preface to the Third Edition
Preface to the Second Edition
Preface to the First Edition
1 General Principles 1
2 Attachment to and Entry of Microorganisms into the Body 9
3 Events Occurring Immediately After the Entry of the Microorganism 60
4 The Encounter of the Microbe with the Phagocytic Cell 75
5 The Spread of Microbes through the Body 106
6 The Immune Response to Infection 136
7 Microbial Strategies in Relation to the Immune Response 168
8 Mechanisms of Cell and Tissue Damage 197
9 Recovery from Infection 278
10 Failure to Eliminate Microbe 307
11 Host and Microbial Factors Influencing Susceptibility 328
12 Vaccines 357
Appendix 379
Conclusions 386
Glossary 389
Index 399
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