miRNA Regulation of the Translational Machinery / Edition 1

miRNA Regulation of the Translational Machinery / Edition 1

by Robert Rhoads
     
 

ISBN-10: 3642031021

ISBN-13: 9783642031021

Pub. Date: 12/28/2009

Publisher: Springer Berlin Heidelberg

The silencing of gene expression by small interfering RNAs has been recognized for only a relatively short time, but this has transformed our understanding of both transcriptional and post-transcriptional gene regulatory mechanisms. Multiple pathways culminate in formation of an RNA-induced silencing complex (RISC) containing a member of the Argonaute protein

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Overview

The silencing of gene expression by small interfering RNAs has been recognized for only a relatively short time, but this has transformed our understanding of both transcriptional and post-transcriptional gene regulatory mechanisms. Multiple pathways culminate in formation of an RNA-induced silencing complex (RISC) containing a member of the Argonaute protein family bound to a 22-nt RNA strand that interacts with a target mRNA or gene through Watson-Crick base pairing. One consequence is mRNA-specific inhibition of protein synthesis. Evidence has been presented for diverse mechanisms, but there is not universal agreement in the field of how RISCs affect the translational machinery. The chapters collected in this volume represent contribution by leaders in the search to understand how miRNAs affect translation. They include chapters representing work in plants and Caenorhabditis elegans, the biological systems that originally led to the discovery of small interfering RNAs, but also include chapters on mammalian systems, with special emphasis on regulation of a key tumor suppressor and a protein that restricts human immunodeficiency virus 1 (HIV-1).

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Product Details

ISBN-13:
9783642031021
Publisher:
Springer Berlin Heidelberg
Publication date:
12/28/2009
Series:
Progress in Molecular and Subcellular Biology Series, #50
Edition description:
2010
Pages:
115
Product dimensions:
6.10(w) x 9.30(h) x 0.60(d)

Table of Contents

1 Understanding How miRNAs Post-Transcriptionally Regulate Gene Expression Marc R. Fabian Thomas R. Sundermeier Nahum Sonenberg 1

2 Translational Control of Endogenous MicroRNA Target Genes in C. elegans Benjamin A. Hurschler Xavier C. Ding Helge Groβhans 21

3 Translational Inhibition by MicroRNAs in Plants Bin Yu Hai Wang 41

4 Regulation of p27kip1 mRNA Expression by MicroRNAs Aida Martínez-Sánchez Fátima Gebauer 59

5 The Inhibitory Effect of Apolipoprotein B mRNA-Editing Enzyme Catalytic Polypeptide-Like 3G (APOBEC3G) and Its Family Members on the Activity of Cellular MicroRNAs Hui Zhang 71

6 MicroRNA-Mediated mRNA Deadenylation and Repression of Protein Synthesis in a Mammalian Cell-Free System Motoaki Wakiyama Shigeyuki Yokoyama 85

7 miRNA Effects on mRNA Closed-Loop Formation During Translation Initiation Traude H. Beilharz David T. Humphreys Thomas Preiss 99

Index 113

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