Mitochondria and Cancer

by Keshav Singh (Editor), Leslie Costello (Editor)

Overview

Nearly a century of scientific research has revealed that mihondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mihondria of normal and cancer cells have been described. These include differences in mihondrial metabolic activity, molecular composition of mihondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mihondrial proteins. This book, Mihondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mihondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mihondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy.

Product Details

ISBN-13:	9781441927385
Publisher:	Springer New York
Publication date:	10/29/2010
Edition description:	Softcover reprint of hardcover 1st ed. 2009
Pages:	289
Product dimensions:	6.10(w) x 9.25(h) x 0.36(d)

Table of Contents

Mihondria and Cancer.- Warburg and his Legacy.- The Lipogenic Switch in Cancer.- Citrate Metabolism in Prostate and Other Cancers.- Integration of Genetic, Proteomic, and Metabolic Approaches in Tumor Cell Metabolism.- Mihondrial Respiration and Differentiation.- Integration of Energy Metabolism and Control of Apoptosis in Tumor Cells.- Energy Generating Pathways and the Tumor Suppressor p53.- Mihondrial Tumor Suppressors.- Mihondria in Hematology.- Mihondria and Oncocytomas.- Mihondria as Targets for Cancer Therapy.- Reversing the Warburg Effect: Metabolic Modulation as a Novel Cancer Therapy.- Mihondrial Nanotechnology for Cancer Therapy.