Mitochondria and Cancer / Edition 1

Mitochondria and Cancer / Edition 1

by Keshav Singh, Leslie Costello
     
 

Nearly a century of scientific research has revealed that mihondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mihondria of normal and cancer cells have been described. These include differences in mihondrial metabolic activity, molecular composition of mihondria and mtDNA sequence, as

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Overview

Nearly a century of scientific research has revealed that mihondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mihondria of normal and cancer cells have been described. These include differences in mihondrial metabolic activity, molecular composition of mihondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mihondrial proteins. This book, Mihondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mihondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mihondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy.

Product Details

ISBN-13:
9780387848341
Publisher:
Springer New York
Publication date:
12/02/2008
Edition description:
2009
Pages:
289
Product dimensions:
6.30(w) x 9.30(h) x 0.70(d)

Meet the Author

Table of Contents

Warburg and the Warburg hypothesis.- The marriage of genomics, proteomics and intermediary metabolism: exciting and dangerous.- Oxidative phosphorylation: the link between metabolism and cancer.- Control of glycosis and oxidative phosphorylation in fast growing tumor cells.- The role of citrate metabolism in prostate malignancy and other tumors.- The role of mihondria in the lipogenic.- Mihondrial apoptosis pathways in cancer.- Mihondrial tumor suppressors and neoplastic transformation.- Mihondrial DNA mutations and tumorigenesis.- SDHD in parganglioma.- Mihondria in hematogic maliagncies.- Mihondria and oncocytomas.- Extracellular matrix signaling by mihondria.- Mihondria as biomarkers of cancer.- Mihondria as target of cancer therapy.

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