Mitochondria and Cancer / Edition 1

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Overview

The book begins with a general overview of Warburg Hypothesis, mihondrial structure and function, and then outline more specifically the metabolic and molecular alterations in mihondria that are associated with human cancer and their clinical implications. An emphasis is also placed on mtDNA mutations and their potential role in carcinogenesis. The potential use of mihondria as biomarkers for early detection of cancer, or as unique cellular targets for novel and selective anti-cancer agents will also be discussed.

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Product Details

  • ISBN-13: 9780387848341
  • Publisher: Springer New York
  • Publication date: 12/2/2008
  • Edition description: 2009
  • Edition number: 1
  • Pages: 289
  • Product dimensions: 6.30 (w) x 9.30 (h) x 0.70 (d)

Table of Contents

Warburg and the Warburg hypothesis.- The marriage of genomics, proteomics and intermediary metabolism: exciting and dangerous.- Oxidative phosphorylation: the link between metabolism and cancer.- Control of glycosis and oxidative phosphorylation in fast growing tumor cells.- The role of citrate metabolism in prostate malignancy and other tumors.- The role of mihondria in the lipogenic.- Mihondrial apoptosis pathways in cancer.- Mihondrial tumor suppressors and neoplastic transformation.- Mihondrial DNA mutations and tumorigenesis.- SDHD in parganglioma.- Mihondria in hematogic maliagncies.- Mihondria and oncocytomas.- Extracellular matrix signaling by mihondria.- Mihondria as biomarkers of cancer.- Mihondria as target of cancer therapy.

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