Mitochondria and Cancer / Edition 1

Mitochondria and Cancer / Edition 1

by Keshav Singh
     
 

ISBN-10: 1441927387

ISBN-13: 9781441927385

Pub. Date: 10/29/2010

Publisher: Springer New York

The book begins with a general overview of Warburg Hypothesis, mitochondrial structure and function, and then outline more specifically the metabolic and molecular alterations in mitochondria that are associated with human cancer and their clinical implications. An emphasis is also placed on mtDNA mutations and their potential role in carcinogenesis. The potential use…  See more details below

Overview

The book begins with a general overview of Warburg Hypothesis, mitochondrial structure and function, and then outline more specifically the metabolic and molecular alterations in mitochondria that are associated with human cancer and their clinical implications. An emphasis is also placed on mtDNA mutations and their potential role in carcinogenesis. The potential use of mitochondria as biomarkers for early detection of cancer, or as unique cellular targets for novel and selective anti-cancer agents will also be discussed.

Product Details

ISBN-13:
9781441927385
Publisher:
Springer New York
Publication date:
10/29/2010
Edition description:
Softcover reprint of hardcover 1st ed. 2009
Pages:
289
Product dimensions:
6.10(w) x 9.25(h) x 0.36(d)

Table of Contents

Warburg and the Warburg hypothesis.- The marriage of genomics, proteomics and intermediary metabolism: exciting and dangerous.- Oxidative phosphorylation: the link between metabolism and cancer.- Control of glycosis and oxidative phosphorylation in fast growing tumor cells.- The role of citrate metabolism in prostate malignancy and other tumors.- The role of mihondria in the lipogenic.- Mihondrial apoptosis pathways in cancer.- Mihondrial tumor suppressors and neoplastic transformation.- Mihondrial DNA mutations and tumorigenesis.- SDHD in parganglioma.- Mihondria in hematogic maliagncies.- Mihondria and oncocytomas.- Extracellular matrix signaling by mihondria.- Mihondria as biomarkers of cancer.- Mihondria as target of cancer therapy.

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