Mitochondria and the Heart / Edition 1

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The function of the heart is highly dependent on oxidative energy that is generated in mihondria. Defects in mihondrial structure and function can be found in association with cardiovascular diseases. Mihondria and the Heart discusses the role that mihondria plays in cardiovascular disease, including biogenesis and function of cardiac mihondria during normal growth, development and aging. In addition, nonbioenergetic, biogenesis and degradation pathways are explored. Understanding these pathways and the effects that mihondrial defects have in cardiac pathology is extremely important in establishing the diagnosis and treatment of mihondrial-based cardiac diseases.

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Product Details

  • ISBN-13: 9780387255743
  • Publisher: Springer US
  • Publication date: 5/5/2005
  • Series: Developments in Cardiovascular Medicine Series, #256
  • Edition description: 2005
  • Edition number: 1
  • Pages: 400
  • Product dimensions: 6.40 (w) x 9.58 (h) x 1.08 (d)

Table of Contents

An Introduction to Mihondria and the Heart.- Mihondrial Bioenergetics in the Heart.- Heart Mihondrial Biogenesis.- ROS Generation, Antioxidants, and Cell Death.- Myocardial Ischemia and Cardioprotection.- Mihondria Dysfunction in Cardiomyopathy and Heart Failure.- Fatty Acid and Glucose Metabolism in Cardiac Disease.- Mihondria in Pediatric Cardiology.- Mihondria and the Aging Heart.- Heart Mihondria Signaling Pathways.- Treatment of Mihondrial-Based Cardiac Diseases. Targeting the Organelle.- Future Frontiers in Mihondrial Cardiac Biology.

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