Mitochondria
Mitochondria are subcellular organelles that function as ¨power plants¨ for the cell, generating energy in the form of ATP from glucose, oxygen, and other molecules. Thought to have arisen about 2 billion years ago when an aerobic bacterium invaded the primitive eukaryotic cell, they have their own DNA, undergo fission and fusion independently, and play an important role in programmed cell death.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology discusses the evolution of mitochondria, their functions in cells, and the numerous diseases in which mitochondrial dysfunction is implicated. The contributors also examine mitochondrial biogenesis, the molecular mechanisms underlying fission and fusion, how proteins are imported from the cytoplasm, and the organization of the mitochondrial DNA.

This book includes chapters covering the involvement of mitochondria in Parkinson's disease, encephalopathies, tumorigenesis, muscular dystrophy, and other diseases, as well as aging. It is thus a vital reference for all cell and molecular biologists, as well as researchers working on muscle and neurodegenerative diseases, the role of metabolism in aging, and cancer.
1136507572
Mitochondria
Mitochondria are subcellular organelles that function as ¨power plants¨ for the cell, generating energy in the form of ATP from glucose, oxygen, and other molecules. Thought to have arisen about 2 billion years ago when an aerobic bacterium invaded the primitive eukaryotic cell, they have their own DNA, undergo fission and fusion independently, and play an important role in programmed cell death.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology discusses the evolution of mitochondria, their functions in cells, and the numerous diseases in which mitochondrial dysfunction is implicated. The contributors also examine mitochondrial biogenesis, the molecular mechanisms underlying fission and fusion, how proteins are imported from the cytoplasm, and the organization of the mitochondrial DNA.

This book includes chapters covering the involvement of mitochondria in Parkinson's disease, encephalopathies, tumorigenesis, muscular dystrophy, and other diseases, as well as aging. It is thus a vital reference for all cell and molecular biologists, as well as researchers working on muscle and neurodegenerative diseases, the role of metabolism in aging, and cancer.
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Mitochondria

Mitochondria

Mitochondria

Mitochondria

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Overview

Mitochondria are subcellular organelles that function as ¨power plants¨ for the cell, generating energy in the form of ATP from glucose, oxygen, and other molecules. Thought to have arisen about 2 billion years ago when an aerobic bacterium invaded the primitive eukaryotic cell, they have their own DNA, undergo fission and fusion independently, and play an important role in programmed cell death.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology discusses the evolution of mitochondria, their functions in cells, and the numerous diseases in which mitochondrial dysfunction is implicated. The contributors also examine mitochondrial biogenesis, the molecular mechanisms underlying fission and fusion, how proteins are imported from the cytoplasm, and the organization of the mitochondrial DNA.

This book includes chapters covering the involvement of mitochondria in Parkinson's disease, encephalopathies, tumorigenesis, muscular dystrophy, and other diseases, as well as aging. It is thus a vital reference for all cell and molecular biologists, as well as researchers working on muscle and neurodegenerative diseases, the role of metabolism in aging, and cancer.

Product Details

ISBN-13: 9781936113354
Publisher: Cold Spring Harbor Laboratory Press
Publication date: 09/30/2013
Series: Cold Spring Harbor Perspectives in Biology
Pages: 270
Product dimensions: 9.30(w) x 13.50(h) x 0.90(d)

Table of Contents

Preface

Mitochondrial Evolution
Michael W. Gray

Mitochondrial DNA Genetics and the Heteroplasmy Conundrum in Evolution and Disease
Douglas C. Wallace and Dimitra Chalkia

Mechanisms of Protein Sorting in Mitochondria
Diana Stojanovski, Maria Bohnert, Nikolaus Pfanner, and Martin van der Laan

The Mitochondrial Nucleoid: Integrating Mitochondrial DNA into Cellular Homeostasis
Robert Gilkerson, Liliana Bravo, Iraselia Garcia, Norma Gaytan, Alan Herrera, Alicia Maldonado, and Brandi Quintanilla

Clinical and Molecular Features of POLG-Related Mitochondrial Disease
Jeffrey D. Stumpf, Russell P. Saneto, and William C. Copeland

Mitochondrial Biogenesis through Activation of Nuclear Signaling Proteins
John E. Dominy and Pere Puigserver

Mechanisms of Mitochondrial Fission and Fusion
Alexander M. van der Bliek, Qinfang Shen, and Sumihiro Kawajiri

Mitochondrial Quality Control Mediated by PINK1 and Parkin: Links to Parkinsonism
Derek Narendra, John E. Walker, and Richard Youle

Mitochondrial Trafficking in Neurons
Thomas L. Schwarz

Where Killers Meet-Permeabilization of the Outer Mitochondrial Membrane during Apoptosis
Tom Bender and Jean-Claude Martinou

The Role of Mitochondria in Cellular Iron-Sulfur Protein Biogenesis: Mechanisms, Connected Processes, and Diseases
Oliver Stehling and Roland Lill

Altered Sulfide (H2S) Metabolism in Ethylmalonic Encephalopathy
Valeria Tiranti and Massimo Zeviani

Mitochondrial Dysfunction and Defective Autophagy in the Pathogenesis of Collagen VI Muscular Dystrophies
Paolo Bernardi and Paolo Bonaldo

Relevance of Mitochondrial Genetics and Metabolism in Cancer Development
Giuseppe Gasparre, Anna Maria Porcelli, Giorgio Lenaz, and Giovanni Romeo

Mitochondrial Metabolism, Sirtuins, and Aging
Michael N. Sack and Toren Finkel

Index
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