Mobile DNA: Finding Treasure in Junk

Mobile DNA: Finding Treasure in Junk

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by Haig H. Kazazian
     
 

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ISBN-10: 0137070624

ISBN-13: 9780137070626

Pub. Date: 04/18/2011

Publisher: FT Press

This book thoroughly reviews our current scientific understanding of the significant role that mobile genetic elements play in the evolution and function of genomes and organisms–from plants and animals to humans. Highly-regarded geneticist Haig Kazazian offers an accessible intellectual history of the field’s research strategies and concerns,

Overview

This book thoroughly reviews our current scientific understanding of the significant role that mobile genetic elements play in the evolution and function of genomes and organisms–from plants and animals to humans. Highly-regarded geneticist Haig Kazazian offers an accessible intellectual history of the field’s research strategies and concerns, explaining how advances opened up new questions, and how new tools and capabilities have encouraged progress in the field.

Kazazian introduces the key strategies and approaches taken in leading laboratories (including his own) to gain greater insight into the large proportion of our genome that derives from mobile genetic elements, including viruses, plasmids, and transposons. He also presents intriguing insights into long-term research strategies that may lead to an even deeper understanding.

Product Details

ISBN-13:
9780137070626
Publisher:
FT Press
Publication date:
04/18/2011
Pages:
288
Product dimensions:
6.10(w) x 9.10(h) x 0.80(d)

Related Subjects

Table of Contents

Preface: Thoughts on Doing Science xii

Chapter 1 Introduction to Mobile DNA 1

Chapter 2 Varieties of Mobile DNA 5

Chapter 3 DNA Transposons 19

Chapter 4 Mobile DNA of Model Organisms 29

Chapter 5 Exceptional Scientists Working on Mobile DNA in Lower Organisms 35

Chapter 6 Role of Bioinformatics in Genome Analysis 43

Chapter 7 The Prologue 49

Chapter 8 "Welcome to the Wonderful World of LINEs" 59

Chapter 9 An Experimental Breakthrough 73

Chapter 10 Reverse Transcriptase to the Rescue 81

Chapter 11 A Quirk of L1 Elements-A Lousy 3' End Is Important for Genome Evolution 85

Chapter 12 A Tour de Force from Tom Eickbush 89

Chapter 13 "I don't believe all those colonies represent retrotransposition events." 93

Chapter 14 L1 Encodes an Endonuclease 101

Chapter 15 The Jocks 105

Chapter 16 The Mayor and the Frenchman 115

Chapter 17 Ostertag's Coups 121

Chapter 18 The Independent Canadian 133

Chapter 19 The Musician Scientist 141

Chapter 20 Young Ladies in the Back Bay 145

Chapter 21 The Brilliant Young Lady from China 157

Chapter 22 Hiroki's Big Surprises 163

Chapter 23 A Young Man with a Purpose 173

Chapter 24 Other Mobile DNA in Mammalian Genomes 179

Chapter 25 Effects of Retrotransposons on Mammalian Genomes 187

Chapter 26 Host Factors Involved in L1 Retrotransposition 201

Chapter 27 Why Mobile DNA? 207

Chapter 28 The Future of Mobile DNA Research 209

Chapter 29 Predictions for Mobile DNA 221

References 225

Glossary 249

Index 255

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Mobile DNA 2 out of 5 based on 0 ratings. 2 reviews.
mpc814 More than 1 year ago
I'm interested in this subject, and have read about it before, with good results. This is a highly academic read, seems almost a text book. Not for the casual scientific reader. Unfortunately, I couldn't understand most of it beyond the introductory concepts. I'm sure its fascinating for the professional research geneticist.
Anonymous More than 1 year ago