Modeling Biomolecular Networks: An Introduction to Systems Biology

by Anirvan M. Sengupta

Overview

This book describes the essentials of a mathematical description of the dynamics of biochemical networks. It covers both deterministic and stochastic aspects of the dynamics. After providing a brief introduction to basic molecular biology, the book describes fundamentals of chemical kinetics. The chapter on signal transduction makes contact with ideas from feedback circuit analysis and signal processing. The chapter on switches and oscillators analyses in detail biological examples, both natural and synthetic. Excitable systems are introduced and contrasted with oscillators. The last chapter deals with pattern formation and development and brings us to current questions of robustness of performance of developmental networks. The book provides brief introductions to some of the mathematical tools required in the main text and in a dedicated appendix. The emphasis, throughout, is on understanding of the essential dynamical aspects rather than just on recipes to build complex models.

Product Details

ISBN-13:	9780198568049
Publisher:	Oxford University Press
Publication date:	11/17/2025
Pages:	208
Product dimensions:	0.10(w) x 0.10(h) x 0.10(d)

Table of Contents

1. Introduction2. Chemical Kinetics I: Basics3. Chemical Kinetics II: Stochastic Aspects4. Signal Transduction5. Genetic Switches6. Biological Oscillators7. Excitable Media8. Multicellular Development and Spatial Structure9. Mathematical Appendices

Editorial Reviews

"A highly welcome book in an important area."—David Weitz, Harvard University

"This field is probably in the middle of a transition from small science to big science."—Richard Berry, University of Oxford

From the Publisher