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Models of Cellular Regulation
     

Models of Cellular Regulation

by Baltazar Aguda, Avner Friedman
 

ISBN-10: 0198570910

ISBN-13: 9780198570912

Pub. Date: 09/15/2008

Publisher: Oxford University Press

The human genome of three billion letters has been sequenced. So have the genomes of thousands of other organisms. With unprecedented resolution, modern technologies are allowing us to peek into the world of genes, biomolecules, and cells - and flooding us with data of immense complexity that we are just barely beginning to understand. A huge gap separates our

Overview

The human genome of three billion letters has been sequenced. So have the genomes of thousands of other organisms. With unprecedented resolution, modern technologies are allowing us to peek into the world of genes, biomolecules, and cells - and flooding us with data of immense complexity that we are just barely beginning to understand. A huge gap separates our knowledge of the components of a cell and what is known from our observations of its physiology. The authors have written this graduate textbook to explore what has been done to close this gap of understanding between the realms of molecules and biological processes. They have gathered together illustrative mechanisms and models of gene regulatory networks, DNA replication, the cell cycle, cell death, differentiation, cell senescence, and the abnormal state of cancer cells. The mechanisms are biomolecular in detail, and the models are mathematical in nature. The interdisciplinary presentation will be of interest to both biologists and mathematicians and every discipline in between.

Product Details

ISBN-13:
9780198570912
Publisher:
Oxford University Press
Publication date:
09/15/2008
Series:
Oxford Graduate Texts Series
Edition description:
New Edition
Pages:
256
Product dimensions:
6.70(w) x 9.80(h) x 0.60(d)

Table of Contents

1. General Introduction
2. From Molecules to a Living Cell
3. Mathematical and Computational Modeling Tools
4. Gene regulatory networks: from DNA to metabolites and back
5. Control of DNA replication in a prokaryote
6. The Eukaryotic Cell Cycle Engine
7. Cell Cycle Control
8. Cell Death
9. Cell Differentiation
10. Cell Aging and Renewal
11. Multiscale Modeling of Cancer

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