Modern Immunohistochemistry

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Overview

Diagnostic pathology is an inherently flawed science due to the many possible interpretations of various tissues. However, the application of immunohistochemical stains as a diagnostic tool has been widely used since the 1990s as an extremely effective ancillary technique that removes much subjectivity from the practice. In fact, immunohistochemistry has supplanted simple morphologic evaluation as the definitive diagnostic method for a wide array of tumor types. This book offers a new and modern atlas-based resource for this science. Every anatomic region is covered in detail, and major diseases contain side-by-side examples of other ancillary staining techniques for comparison. The text is geared toward both the resident and practitioner of anatomic pathology and is supplemented with histograms, algorithms, and guides to the application and interpretation of uncommon antigens and immunostains. Not only is the book illustrated with more than 600 high-quality photomicrographs, but a companion CD-ROM of all images in downloadable format is included.

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Editorial Reviews

From the Publisher
"The strengths of this book are the side-by-side, similarly aligned pictures with various stains, easy to understand tables, and succinct text. The atlas covers all of the major anatomic sites and related tumors. Each anatomic site has a table with all of the major tumors and the associated staining patterns, allowing readers easy and quick access to immunohistochemical interpretation in an anatomically based approach....The usefulness of this book stems from its uniqueness and high quality images. Most books on immunohistochemistry are geared more toward those in the field of immunohistochemistry and not toward the practicing pathologist. With this book, pathologists are able to see proper interpretation of mmunohistochemistry in side-by-side comparisons. There is less emphasis on the science of immunohistochemistry, and more emphasis on interpretation and its proper usage."
--Doody's Review Service
Doody's Review Service
Reviewer: Daniel John Lalich, M.D. (University of Kansas Medical Center)
Description: This atlas contains side-by-side comparisons of immunohistochemical stains and their interpretation for organ systems and related tumors. All images in the book are also included on the enclosed CD-ROM.
Purpose: The goal is to provide a modern atlas-based resource for immunohistochemical interpretation of the major anatomic sites and related tumors. This atlas effectively provides color pictures and interpretations to address the subtleties pathologists commonly encounter when trying to interpret immunohistochemical stains.
Audience: The book is geared toward practicing pathologists and pathology residents, both of whom sometimes need visual reinforcement for interpretation in the evolving field of immunohistochemistry. The authors are renowned for their knowledge of the subject and are leaders in this field.
Features: The strengths of this book are the side-by-side, similarly aligned pictures with various stains, easy to understand tables, and succinct text. The atlas covers all of the major anatomic sites and related tumors. Each anatomic site has a table with all of the major tumors and the associated staining patterns, allowing readers easy and quick access to immunohistochemical interpretation in an anatomically based approach. The arrangement of figures and associated captions leads to occasional searching for the correct text associated with the figure.
Assessment: The usefulness of this book stems from its uniqueness and high quality images. Most books on immunohistochemistry are geared more toward those in the field of immunohistochemistry and not toward the practicing pathologist. With this book, pathologists are able to see proper interpretation of immunohistochemistry in side-by-side comparisons. There is less emphasis on the science of immunohistochemistry, and more emphasis on interpretation and its proper usage.
From The Critics
Reviewer:Daniel John Lalich, M.D. (University of Kansas Medical Center)
Description:This atlas contains side-by-side comparisons of immunohistochemical stains and their interpretation for organ systems and related tumors. All images in the book are also included on the enclosed CD-ROM.
Purpose:The goal is to provide a modern atlas-based resource for immunohistochemical interpretation of the major anatomic sites and related tumors. This atlas effectively provides color pictures and interpretations to address the subtleties pathologists commonly encounter when trying to interpret immunohistochemical stains.
Audience:The book is geared toward practicing pathologists and pathology residents, both of whom sometimes need visual reinforcement for interpretation in the evolving field of immunohistochemistry. The authors are renowned for their knowledge of the subject and are leaders in this field.
Features:The strengths of this book are the side-by-side, similarly aligned pictures with various stains, easy to understand tables, and succinct text. The atlas covers all of the major anatomic sites and related tumors. Each anatomic site has a table with all of the major tumors and the associated staining patterns, allowing readers easy and quick access to immunohistochemical interpretation in an anatomically based approach. The arrangement of figures and associated captions leads to occasional searching for the correct text associated with the figure.
Assessment:The usefulness of this book stems from its uniqueness and high quality images. Most books on immunohistochemistry are geared more toward those in the field of immunohistochemistry and not toward the practicing pathologist. With this book, pathologists are able to see proper interpretation of immunohistochemistry in side-by-side comparisons. There is less emphasis on the science of immunohistochemistry, and more emphasis on interpretation and its proper usage.
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Product Details

Meet the Author

Peiguo Chu, MD, PhD, is Director of Surgical Pathology at City of Hope National Medical Center, Duarte, California.

Lawrence Weiss, MD, is Chairman of Pathology at City of Hope National Medical Center, Duarte, California. Dr Weiss is the editor of the Cambridge Illustrated Surgical Pathology series and the author of Lymph Nodes, a book within the series.

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Table of Contents

1. Modern tumor immunohistochemistry; 2. Skin tumors; 3. Tumors of the head and neck; 4. Tumors of the lung and mediastinum; 5. Tumors of the endocrine system; 6. Tumors of the digestive system; 7. Tumors of the genitourinary system; 8. Tumors of the breast; 9. Hematopoietic tumors; 10. Tumors of soft tissue and bone; 11. Tumors of the central nervous system; 12. Metastatic carcinoma of unknown primary origin.
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