Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning / Edition 1

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Overview

When first introduced, antisense oligonucleotides were hailed as the long awaited magic bullet that would provide an unprecedented level of specificity in controlling gene expression. Following this initial enthusiasm, antisense oligonucleotides have been maligned as nonspecific, toxic, and essentially useless. However, application of antisense oligonucleotide technology in the nervous system stands apart from the use of this technique in peripheral systems, largely because of its enormous success. The source of this success remains a matter of some controversy. Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning addresses the origins of that controversy and determines whether the nervous system is a privileged site for antisense oligonucleotide action and not subject to the same vagaries and pitfalls as non-neuronal systems. Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning contains chapters by experts in the field that focus on the use of this technique in a variety of behavioral systems, as well as rapid and nonspecific effects and the uptake and metabolism of antisense oligonucleotides by the nervous system. Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning features: experts in the field reporting on the use of antisense oligonucleotide technology in a variety of behavioral systems, including pain control, circadian rhythms, ingestion and control of water balance, and reproductive behaviors; the novel use of plasmids to express antisense RNA in the nervous system; the biodistribution and metabolism of antisense oligonucleotides in the nervous system; rapid and unusual effects; and non-specific effects.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Herbert H. Engelhard, MD, PhD (University of Illinois at Chicago College of Medicine)
Description: This book is a compilation of chapters from various authors, all of which relate to the administration of antisense oligonucleotides directly into the brains of experimental animals.
Purpose: The purpose is to compile relevant information on antisense technology, as it relates to modulation of brain function, into a compact volume. This is a worthy goal, and the editor is successful in achieving it.
Audience: This book is written for research scientists in the field of neurobiology. Authorities in the this field are now just emerging.
Features: Issues of distribution and stability of oligodeoxynucleotides in the brain are covered, as well as intracellular uptake and nonspecific effects. Their effects on dopamine, GABA and opioid receptors, thirst control, and steroid and endocrine-mediated behaviors are then discussed. The main shortcoming of the book is unavoidable: it is an attempt to summarize literature that is extensive and rapidly expanding, and therefore the contents will quickly become out-of-date. Despite this, the book is indeed useful for the neurobiologist interested in possible applications of antisense technology.
Assessment: This is a practically unique contribution and it does fill a need. It should be added to the institutional libraries of all universities and corporations in the process of conducting brain research.
Booknews
Addresses the origins of controversy in the scientific community surrounding the use of antisense oligonucleotides, and attempts to determine whether the nervous system is a privileged site for antisense oligonucleotide action and not subject to the same pitfalls as non-neuronal systems. Focuses on the use of this technique in a variety of behavioral systems, as well as rapid and nonspecific effects and the uptake and metabolism of antisense oligonucleotides by the nervous system. Annotation c. by Book News, Inc., Portland, Or.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780792382423
  • Publisher: Springer US
  • Publication date: 9/5/2007
  • Series: Perspectives in Antisense Science Series , #1
  • Edition description: 1999
  • Edition number: 1
  • Pages: 188
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.50 (d)

Table of Contents

1. The Use of Antisense Technologies to Understand Neural Functioning: Fact or Fiction? M.M. McCarthy. 2. Tissue Distribution, Cellular Uptake, and Intracellular Localization and Stability of Centrally Administered Oligonucleotides in the Brain: Implications for Behavioral and Physiological Effects of Antisense Oligonucleotides; W. Sommer, et al. 3. Non-Specific Effects of Centrally Administered Oligonucleotides; R. Spanagel, et al. 4. Rapid Onset of Antisense Effects: Evidence for a Close Link Between Gene Expression and Neuronal Activity; I.D. Neumann, Q.J. Pittman. 5. Effects of Dopamine Receptor Antisense RNA Expression Vectors in the Nervous System; G. Davidkova, et al. 6. Modification of Native GABAA Receptor Assemblies Using Antisense Oligonucleotides; D.R. Grayson, S. Vicini. 7. Antisense Oligodeoxynucleotides as Specific Tools for Studying Opioid Receptor-Mediated Analgesia; L.F. Tseng. 8. Antisense Approaches to Investigate the Neuroendocrine Control of Thirst and Sodium Appetite in the Rat; R.S. Sakai, et al. 9. Steroid-Mediated Behaviors and their Regulation by Antisense Oligodeoxynucleotides; S.K. Mani, P.K. Dash. 10. Modulation of Endocrine and Behavioral Rhythms with Antisense Oligonucleotides; K. Scarbrough. Index.
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