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From The CriticsReviewer: Herbert H. Engelhard, MD, PhD (University of Illinois at Chicago College of Medicine)
Description: This book is a compilation of chapters from various authors, all of which relate to the administration of antisense oligonucleotides directly into the brains of experimental animals.
Purpose: The purpose is to compile relevant information on antisense technology, as it relates to modulation of brain function, into a compact volume. This is a worthy goal, and the editor is successful in achieving it.
Audience: This book is written for research scientists in the field of neurobiology. Authorities in the this field are now just emerging.
Features: Issues of distribution and stability of oligodeoxynucleotides in the brain are covered, as well as intracellular uptake and nonspecific effects. Their effects on dopamine, GABA and opioid receptors, thirst control, and steroid and endocrine-mediated behaviors are then discussed. The main shortcoming of the book is unavoidable: it is an attempt to summarize literature that is extensive and rapidly expanding, and therefore the contents will quickly become out-of-date. Despite this, the book is indeed useful for the neurobiologist interested in possible applications of antisense technology.
Assessment: This is a practically unique contribution and it does fill a need. It should be added to the institutional libraries of all universities and corporations in the process of conducting brain research.