Molecular Analysis of Cancer / Edition 1

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Leading researchers describe in step-by-step detail their best state-of-the art molecular techniques for elucidating the biochemical processes associated with human cancer. Among the techniques presented for identifying chromosomal rearrangements are fluorescent in situ hybridization (FISH), spectral karyotyping (SKY), comparative genomic hybridization (CGH), microsatellite analysis, PCR and RT-PCR, and DNA fingerprinting. Additional methods include SSCP, DGGE, the nonisotopic RNase cleavage assay, and the protein truncation assay and DNA sequencing for identifying mutations.
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Editorial Reviews

Doody's Review Service
Reviewer: Jochen H. Lorch, MD (Northwestern University Feinberg School of Medicine)
Description: This is a short, concise and surprisingly comprehensive manual with many useful hints.
Purpose: The book is a short manual describing techniques for identification of chromosomal abnormalities. These objectives are worthy and the objectives have been met.
Audience: The manual should be useful for students and scientists alike.
Features: The book covers a broad range of topics and provides many useful suggestions as well as practical guidance for the lab researcher. I liked the rather extensive bibliography at the end of each chapter. Due to the limited scope of the book, some newer techniques such as microarrays are not covered
Assessment: A useful little book which should provide good guidance for the young researcher at the beginning of his or her career. It can be a useful addition to the more extensive standard lab manuals such as Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Laboratory, 2001) and others.

3 Stars from Doody
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Product Details

  • ISBN-13: 9781617371028
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 12/12/2011
  • Series: Methods in Molecular Medicine Series , #68
  • Edition description: Softcover reprint of hardcover 1st ed. 2002
  • Edition number: 1
  • Pages: 304

Table of Contents

Molecular Analysis of Cancer: An Overview
Ken Mills

Detection of Chromosome Abnormalities in Leukemia Using Fluorescence In Situ Hybridization
Lyndal Kearney, Sabrina Tosi, and Rina J. Jaju

Spectral Karyotyping in Cancer Cytogenetics
Eva Hilgenfeld, Cristina Montagna, Hesed Padilla-Nash, Linda Stapleton, Kerstin Heselmeyer-Haddad, and Thomas Ried

Comparative Genomic Hybridization Analysis
Binaifer R. Balsara, Jianming Pei, and Joseph R. Testa

Detection of Chromosomal Deletions by Microsatellite Analysis
Rachel E. Ibbotson and Martin M. Corcoran

Detection and Quantification of Leukemia-Specific Rearrangements
Andreas Hochhaus

Detection of t(2;5)(p23;q35) Translocation by Long-Range PCR of Genomic DNA
Yunfang Jiang, L. Jeffrey Medeiros, and Andreas H. Sarris

Use of DNA Fingerprinting to Detect Genetic Rearrangements in Human Cancer
Vorapan Sirivatanauksorn, Yongyut Sirivatanauksorn, Arthur B. McKie, and Nicholas R. Lemoine

Mutation Analysis of Large Genomic Regions in Tumor DNA Using Single-Strand Conformation Polymorphism: Lessons from the ATM Gene
Igor Vorechovsky

Mutational Analysis of Oncogenes and Tumor Suppressor Genes in Human Cancer Using Denaturing Gradient Gel Electrophoresis
Per Guldberg, Kirsten Grønbæk, Jesper Worm, Per thor Straten, and Jesper Zeuthen

Detection of Mutations in Human Cancer Using Nonisotopic RNase Cleavage Assay
Marianna Goldrick and James Prescott

Mutational Analysis of the Neurofibromatosis Type 1 Gene in Childhood Myelodysplastic Syndromes Using a Protein Truncation Assay
Lucy Side

Mutation Analysis of Cancer Using Automated Sequencing
Amanda Strickson and Carrie Fidler

Detection of Differentially Expressed Genes in Cancer Using Differential Display
Yineng Fu

Genomewide Gene Expression Analysis Using cDNAMicroarrays
Chuang Fong Kong and David Bowtell

Gene Expression Profiling in Cancer Using cDNA Microarrays
Javed Khan, Lao H. Saal, Michael L. Bittner, Yuan Jiang, Gerald C. Gooden, Arthur A. Glatfelter, and Paul S. Meltzer

Wilms Tumor Gene WT1 as a Tumor Marker for Leukemic Blast Cells and Its Role in Leukemogenesis
Haruo Sugiyama
Detection of Aberrant Methylation of the p15INK4B Gene Promoter
Toshiki Uchida

Clonality Studies in Cancer Based on X Chromosome Inactivation Phenomenon
John T. Phelan II and Josef T. Prchal

Telomere Length Changes in Human Cancer
Dominique Broccoli and Andrew K. Godwin

Measurement of Telomerase Activity in Human Hematopoietic Cells and Neoplastic Disorders
Kazuma Ohyashiki and Junko H. Ohyashiki

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