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Overview

An essential resource for graduate students, academic and industrial toxicologists, and environmental health scientists and professionals

Over the course of thirty years and three editions, Introduction to Biochemical Toxicology has been an important source for coverage of the ongoing quest to define the biochemical, cellular, and molecular events induced by toxicants at the cellular and organismic levels. Now, as the principles and methods of molecular and cellular biology as ...

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Molecular and Biochemical Toxicology

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Overview

An essential resource for graduate students, academic and industrial toxicologists, and environmental health scientists and professionals

Over the course of thirty years and three editions, Introduction to Biochemical Toxicology has been an important source for coverage of the ongoing quest to define the biochemical, cellular, and molecular events induced by toxicants at the cellular and organismic levels. Now, as the principles and methods of molecular and cellular biology as well as genomic sciences play an ever increasing role in mechanistic toxicology, significant changes have been made to the book, resulting in this important new edition—now titled Molecular and Biochemical Toxicology, Fourth Edition.

Much more than an introductory text, this crucial new edition has been completely revised to provide timely and thorough coverage of the underlying biochemical, molecular, and cellular mechanisms through which toxicants produce their adverse effects. Toxicological issues are covered from the molecule to the cell to the organ level. Complex methods used in toxicology are also described in a straightforward, easy-to-understand style. Additional features of this new edition include:

  • New chapters that explore the interface between toxicology and genomic sciences, including: bioinformatics, proteomics, metabolomics, and toxicogenomics

  • Increased emphasis on structure, mechanism, and regulation of xenobiotic metabolizing enzymes, toxicogenetics, and xenobiotic transporters

  • Additional new chapters on: molecular epidemiology and genetic susceptibility, DNA damage and mutagenesis, DNA repair, mechanisms of cell death, mitochondrial dysfunction, metals, reproductive toxicology, developmental toxicology, and reactive oxygen/metabolites and toxicity

Molecular and Biochemical Toxicology, Fourth Edition guides graduate students, toxicologists, and environmental health professionals through the principles of molecular and biochemical toxicology and the complex mechanisms of toxicity. Whether it's used in the classroom or in industry, research, or academia, this book is essential for anyone interested in understanding the molecular mechanisms through which toxicants produce adverse effects.

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Editorial Reviews

From the Publisher
"A good introductory textbook covering the biochemical toxicology of organic substances and the relevant methodology in some detail.... It offers good value for money and can be recommended as a textbook for appropriate courses." (BTS Newsletter, Summer 2009)
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Product Details

  • ISBN-13: 9781118679722
  • Publisher: Wiley
  • Publication date: 3/5/2013
  • Sold by: Barnes & Noble
  • Format: eBook
  • Edition number: 4
  • Pages: 944
  • File size: 18 MB
  • Note: This product may take a few minutes to download.

Meet the Author

Robert C. Smart, PhD, is a Professor in the Department of Environmental and Molecular Toxicology at North Carolina State University. Together with Dr. Hodgson, he coedited the previous edition of this book.

Ernest Hodgson, PhD, is the William Neal Reynolds Professor of Toxicology at North Carolina State University. He edited A Textbook of Modern Toxicology, Third Edition (Wiley) and is the Editor of the Journal of Biochemical and Molecular Toxicology.

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Table of Contents

1 Molecular and Biochemical Toxicology: Definition and Scope Ernest Hodgson Hodgson, Ernest Robert C. Smart Smart, Robert C. 1

2 Overview of Molecular Techniques in Toxicology: Genes and Transgenes Robert C. Smart Smart, Robert C. 5

3 Toxicogenomics Marjorie F. Oleksiak Oleksiak, Marjorie F. 25

4 Proteomics B. Alex Merrick Merrick, B. Alex 41

5 Metabolomics Nigel Deighton Deighton, Nigel 67

6 Bioinformatics Eric A. Stone Stone, Eric A. Dahlia M. Nielsen Nielsen, Dahlia M. 81

7 Immunochemical Techniques in Toxicology Gerald A. LeBlanc LeBlanc, Gerald A. 109

8 Cellular Techniques Sharon A. Meyer Meyer, Sharon A. 129

9 Structure, Mechanism, and Regulation of Cytochromes P450 Darryl C. Zeldin Zeldin, Darryl C. John M. Seubert Seubert, John M. 147

10 Phase I Metabolism of Toxicants and Metabolic Interactions Ernest Hodgson Hodgson, Ernest Parikshit C. Das Das, Parikshit C. Taehyeon M. Cho Cho, Taehyeon M. Randy L. Rose Rose, Randy L. 173

11 Phase I - Toxicogenetics Ernest Hodgson Hodgson, Ernest Edward L. Croom Croom, Edward L. 205

12 Phase II - Conjugation of Toxicants Gerald A. LeBlanc LeBlanc, Gerald A. 219

13 Regulation and Polymorphisms in Phase II Genes Yoshiaki Tsuji Tsuji, Yoshiaki 239

14 Developmental Effects on Xenobiotic Metabolism Martin J. J. Ronis Ronis, Martin J. J. Helen C. Cunny Cunny, Helen C. 257

15 Cellular Transport and Elimination David S. Miller Miller, David S. 273

16 Mechanisms of Cell Death Mac Law Law, Mac Susan Elmore Elmore, Susan 287

17 Mitochondrial Dysfunction Jun Ninomiya-Tsuji Jun, Ninomiya-Tsuji 319

18 Glutathione-Dependent Mechanisms in Chemically Induced Cell Injury and Cellular Protection Mechanisms Donald J. ReedReed, Donald J. 333

19 Toxicant-Receptor Interactions: Fundamental Principles Richard B. Mailman Mailman, Richard B. 359

20 Reactive Oxygen/Reactive Metabolites and Toxicity Elizabeth L. MacKenzie MacKenzie, Elizabeth L. 389

21 Metals David B. Buchwalter Buchwalter, David B. 413

22 DNA Damage and Mutagenesis Zhigang Wang Wang, Zhigang 441

23 DNA Repair Isabel Mellon Mellon, Isabel 493

24 Carcinogenesis Robert C. Smart Smart, Robert C. Sarah J. Ewing Ewing, Sarah J. Kari D. Loomis Loomis, Kari D. 537

25 Genetic Toxicology R. Julian Preston Preston, R. Julian 587

26 Molecular Epidemiology and Genetic Susceptibility Ruth M. Lunn Lunn, Ruth M. Mariana C. Stern Stern, Mariana C. 607

27 Respiratory Toxicology James C. Bonner Bonner, James C. 639

28 Hepatotoxicity Andrew D. Wallace Wallace, Andrew D. Sharon A. Meyer Meyer, Sharon A. 671

29 Biochemical Mechanisms of Renal Toxicity Joan B. Tarloff Tarloff, Joan B. Andrew D. Wallace Wallace, Andrew D. 693

30 Biochemical Toxicology of the Peripheral Nervous System Jeffry F. Goodrum Goodrum, Jeffry F. Arrel D. Toews Toews, Arrel D. Thomas W. Bouldin Bouldin, Thomas W. 725

31 Biochemical Toxicology of the Central Nervous System Bonita L. Blake Blake, Bonita L. 743

32 Immunotoxicology MaryJane K. Selgrade Selgrade, MaryJane K. Dori R. Germolec Germolec, Dori R. Robert W. Luebke Luebke, Robert W. Ralph J. Smialowicz Smialowicz, Ralph J. Marsha D. Ward Ward, Marsha D. Christal C. Bowman Bowman, Christal C. 765

33 Reproductive Toxicology John F. Couse Couse, John F. 805

34 Developmental Toxicology John F. Couse Couse, John F. 831

35 Dermatotoxicology Nancy A. Monteiro-Riviere Monteiro-Riviere, Nancy A. 851

Index 881

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